[An attenuated strain of Mycobacterium bovis with non-specific immunoadjuvant and immunotherapeutic properties. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG (bacillus Calmette-Guerin) likely activates a Th1 cytokine response that includes induction of interferon. Vaccination with BCG may be immunoprotective against infection with Mycobacterium tuberculosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43028&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43028&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1328" NCI Thesaurus) ( PDQ )]