BARD1

1. [This gene plays a role in cellular response and is susceptible to oncogenic mutations in breast and ovarian cancers. ( NCI )]
   UMLS (NCI) C1332381
   
   BARD1 Gene
   BRCA1 Associated RING Domain 1 Gene
    

   Gene or Genome
   

2. [Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI) ( NCI )]
   UMLS (NCI) C1332437
   
   BRCA1 Associated RING Domain 1
   BRCA1 Associated RING Domain 1 Protein
   BRCA1 Associated RING Domain Protein 1
   BRCA1-Associated RING Domain 1
   
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance