BAG1
[Encoded by human BAG1 Gene as isoforms 1 (274-aa, 31-kD) and 2 (240-aa), acidic (pI 5.3) glutamate-rich BAG1 Protein contains a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. ( NCI )]
UMLS (NCI) C0379646- Amino Acid, Peptide, or Protein
- Biologically Active Substance
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
