[Encoded by human TAF9 Gene (TAF2G Family), 264-aa 29-kDa nuclear TBP-Associated Factor 9 is a small TFIID subunit that binds to the basal transcription factor GTFIIB as well as transcriptional activators. A component of the PCAF complex and of the STAGA transcription coactivator-HAT complex, TAF9 is a p53 coactivator and interacts with viral transactivator VP16. TAF9 and TP53 bind via TP53 N-terminal amino acids that are essential for transcription. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI) ( NCI )]
UMLS (NCI) C0540760 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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