APEX Nuclease-Like 2

[Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. Apurinic/Apyrimidinic Endonuclease 2, a protein encoded by the APEXL2 gene, has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301) ( NCI )]

UMLS (NCI) C1332330

APEXL2
Apurinic/Apyrimidinic Endonuclease 2
Apurinic/Apyrimidinic Endonuclease-Like 2