[ABC Transporter Binding involves temporary non-covalent interaction of a molecule through intermolecular physical forces of attraction with a protein complex that, after conformational change, moves a bound substrate across a cell membrane against a concentration gradient resulting directly from the expenditure of energy. ABC Transporter complexes consist of two conserved six-transmembrane proteins (permeases), two conserved ATP-hydrolyzing peripheral membrane proteins, and a periplasmic substrate-binding protein. ( NCI )]
UMLS (NCI) C1510679