[3-Phosphoinositide Dependent Protein Kinase-1, encoded by the PDPK1 gene, belongs to the Ser/Thr family of protein kinases. This protein phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, p70S6K and p90S6K/RSK. It may play a general role in signaling processes and in development (by similarity). It becomes cytoplasmic and membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. Three isoforms exist from alternative splicing and Isoform 3 is catalytically inactive. (from LocusLink) ( NCI )]
UMLS (NCI) C0541150 - Amino Acid, Peptide, or Protein
- Enzyme
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