[The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. ( NCI )]
UMLS (NCI) C0008846 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: 6,7-Epoxytropine Tropate
Relation/CHD: PRILOCAINE HYDROCHLORIDE 4 %