- 3401. Acetamide, N-methyl-N-[4-[(7-methyl-1H-imidazo[4, 5-f]quinolin-9-yl)amino]phenyl]-, monohydrochloride (9CI)
- (UMLS (NCI) C0970589) Acodazole Hydrochloride;
=Organic Chemical; Pharmacologic Substance ;
| - 3451. Achilles bursitis or tendinitis
- (UMLS (ICD9CM) C0149846) =Disease or Syndrome
|
- 3402. Acetamide, N-[(methylamino)carbonyl]-N-[[(methylamino)carbonyl]oxy]- (9CI)
- [An agent derived from acetohydroxamic acid with potential antineoplastic activity. Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase. In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent's acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. (NCI04) ( NCI )] (UMLS (NCI) C0054633) =Organic Chemical; Pharmacologic Substance
| - 3452. ACHILLOTENOTOMY
- [ ] (UMLS (ICD9CM) C0188472) =Therapeutic or Preventive Procedure
|
- 3403. Acetaminophen #3
- [A synthetic p-aminophenol derivative combined with codeine, anti-inflammatory and analgesic Acetaminophen 3 is used against inflammatory conditions, fever, and pain. Codeine is an opium alkaloid with analgesic properties. The active principal metabolite of phenacetin, Acetaminophen appears to inhibit prostaglandin biosynthesis in the central nervous system and less in peripheral tissues. Equipotent to acetylsalicylic acid, but more toxic, Acetaminophen may cause liver and kidney damage, especially in children. (NCI04) ( NCI )] (UMLS (NCI) C0358847) =Organic Chemical; Pharmacologic Substance
| - 3453. achlorhydria
- [(a-klor-HY-dree-a) A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food. ( NCI )] (UMLS (CSP) C0001075) =Pathologic Function ;
|
- 3404. Acetaminophen Pathway
- [Acetaminophen is one of the world's most commonly used drugs, used for the treatment of pain and fever. Like other NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen has a unique activity profile based in part on its action at its molecular targets, the cyclooxygenase enzymes that produce prostaglandins responsible for pain, fever and inflammation. Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS. Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining. More…
| - 3454. Achlya
- [A genus of ALGAE in the family Saprolegniaceae. They are pathogens of FISHES and INSECTS. ( MSH )] (UMLS (CSP) C0599017) =Alga ;
|
- 3405. Acetaminophen/Acetylcysteine
- (UMLS (NCI) C0678074) =Therapeutic or Preventive Procedure ;
| - 3455. Achomawi
- (UMLS (HL7) C1555628) Achumawi;
=Language =Palaihnihan;
|
- 3406. Acetaminophen/Acetylcysteine/Carmustine
- (UMLS (NCI) C0678073) =Therapeutic or Preventive Procedure ;
| - 3456. Achondrogenesis, Type II
- (UMLS (NCI) C0220685) =Congenital Abnormality ;
|
- 3407. ACETARSONE
- [A pentavalent arsenical compound with antiprotozoal and antihelmintic properties. Although the mechanism of action is not fully known, acetarsone may bind to protein-containing sulfhydryl groups located in the parasite, thereby forming lethal As-S bonds. This may prevent their function and eventually kill the parasite. ( NCI )] (UMLS (NCI) C0050436) =Organic Chemical; Pharmacologic Substance
| - 3457. achondroplasia
- [autosomal dominant disorder that is the most frequent form of short-limb dwarfism; a disturbance of epiphyseal chondroblastic growth, causing inadequate enchondral bone formation. ( CSP )] (UMLS (CSP) C0001080) =Congenital Abnormality; Disease or Syndrome
|
- 3408. acetate
- [salts or esters of acetic acid in which the terminal hydrogen atom is replaced by a metal, for instance copper acetate Cu(CH3COO)2, or where substitution is by a radical, for instance ethyl acetate CH3COOC2H5. ( CSP )] (UMLS (CSP) C0000979) =Organic Chemical; Pharmacologic Substance ;
| - 3458. ACHROMATOPSIA
- [Severely deficient color perception, typically with monochromacy and reduced visual acuity. The atypical form can include normal visual acuity with pseudomonochromacy. ( MSH )] (UMLS (ICD9CM) C0152200) =Disease or Syndrome ;
|
- 3409. acetazolamide
- [carbonic anhydrase inhibitor that is sometimes effective against seizures. ( CSP )] (UMLS (CSP) C0000981) =Organic Chemical; Pharmacologic Substance ;
| - 3459. Achromobacteraceae
- [ ] (UMLS (CSP) C0597951) =Bacterium ;
|
- 3410. Acetic Acid
- [50% V/V acetic acid in water. Used as a urine preservative ( HL7V3.0 )] (UMLS (HL7) C1550049) =Intellectual Product ;
=MaterialEntityAdditive;
| - 3460. Achromycin
- (UMLS (NCI) C0740484) =Organic Chemical; Antibiotic
|
- 3411. ACETIC ACID
- [A synthetic carboxylic acid with antibacterial and antifungal properties. Although, the mechanism of action is not fully known, the undissociated acetic acid may enhance lipid solubility allowing increased fatty acid accumulation on the cell membrane or in other cell wall structures. Acetic acid, as a weak acid, can inhibit carbohydrate metabolism resulting in subsequent death of the organism. ( NCI )] (UMLS (NCI) C0000983) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
| - 3461. ACI, Rat Strain
- [Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumors 46% testes, 16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Will grow transplantable Morris hepatomas 3924A which can be used as a model for the treatment of liver cancer (Yang et al 1995). ( NCI )] (UMLS (NCI) C1510682) =Mammal ;
|
- 3412. Acetic Acid Phenyl Ester
- [A drug being studied in the treatment of cancer. ( NCI )] (UMLS (NCI) C0220893) =Organic Chemical; Pharmacologic Substance ;
| - 3462. Acicloftal
- (UMLS (NCI) C1510770) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 3413. Acetic Acid, Dimethylamide
- (UMLS (NCI) C0058243) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =Acetamides;
Inactive Ingredient Preparations =N,N-DIMETHYLACETAMIDE 60 MG/ML;
| - 3463. acid
- [substances whose aqueous solutions are characterized by a sour taste, the ability to turn blue litmus red, and the ability to react with bases and certain metals to form salts; yields hydrogen ions when dissolved in water, acts as a proton donor, and can accept a pair of electrons to form a covalent bond. ( CSP )] (UMLS (CSP) C0001128) =Chemical ;
|
- 3414. Acetic Acid, Magnesium Salt
- [The acetate salt form of magnesium. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium. ( NCI )] (UMLS (NCI) C0982266) Magnesium Acetate;
MAGNESIUM ACETATE PREPARATION =Organic Chemical; Pharmacologic Substance =[TN406] MAGNESIUM;
TO BE DELETED INGREDIENT PREPARATIONS =MAGNESIUM ACETATE 0.21 GM/L;
MAGNESIUM ACETATE 0.86 GM;
MAGNESIUM ACETATE 21 MG/100ML;
MAGNESIUM ACETATE 32 MG/100ML | - 3464. acid aminoacid ligase
- [Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups. ( MSH )] (UMLS (CSP) C0030952) =Amino Acid, Peptide, or Protein; Enzyme ;
=carbon nitrogen ligase;
=folylpolyglutamate synthase;
E3 ligase;
|
- 3415. Acetic Acid, Potassium Salt
- [The acetate salt form of potassium, an essential macromineral. Potassium maintains intracellular tonicity, is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, production of energy, the synthesis of nucleic acids, maintenance of blood pressure and normal renal function. This agent has potential antihypertensive effects and when taken as a nutritional supplement may prevent hypokalemia. ( NCI )] (UMLS (NCI) C0137984) =Organic Chemical; Pharmacologic Substance =acetate;
[TN403] POTASSIUM =POTASSIUM ACETATE 0.2 MEQ/ML;
POTASSIUM ACETATE 2 MEQ/ML;
POTASSIUM ACETATE 4 MEQ/ML;
Potassium Acetate 1.04 MEQ/ML;
POTASSIUM ACETATE 0.69 GM;
POTASSIUM ACETATE 1.28 GM/L;
POTASSIUM ACETATE 1.96 GM;
POTASSIUM ACETATE 128 MG/100ML;
POTASSIUM ACETATE 130 MG/100ML;
POTASSIUM ACETATE 196 MG;
POTASSIUM ACETATE 196 MG/100ML;
POTASSIUM ACETATE 78.5 MG;
| - 3465. acid anhydride hydrolase
- [heading term for the high energy phosphatases. ( CSP )] (UMLS (CSP) C0206235) =Amino Acid, Peptide, or Protein; Enzyme =hydrolase;
=Adenosine Triphosphatase;
Ca2+ transporting ATPase;
ATP phosphohydrolase (Na+ K+ transporting);
dynein;
GTP phosphohydrolase;
pyrophosphatase;
kinesin;
|
- 3416. Acetic Acid, Sodium Salt
- [The trihydrate sodium salt of acetic acid with alkalinizing, diuretic and electrolyte replacement properties. Following absorption, sodium acetate generates sodium bicarbonate, thereby raising blood and urine pH. In addition, this agent may increase serum sodium concentration. ( NCI )] (UMLS (NCI) C0142785) =Organic Chemical; Pharmacologic Substance ;
=acetate;
[TN404] SODIUM =SODIUM ACETATE, ANHYDROUS;
apraclonidine 10 MG/ML Ophthalmic Solution;
BALNEOL LOTION;
Vincristine 1 MG/ML Injectable Solution;
SODIUM ACETATE 2 MEQ/ML;
SODIUM ACETATE 4 MEQ/ML;
SODIUM ACETATE 5 MEQ/ML;
Sodium Acetate 3.7 MG/ML;
Sodium Acetate 2.2 MG/ML;
SODIUM ACETATE 222 MG;
SODIUM ACETATE 0.015 %;
SODIUM ACETATE 0.11 GM/100ML;
SODIUM ACETATE 0.15 %;
SODIUM ACETATE 0.37 GM;
SODIUM ACETATE 0.38 GM;
SODIUM ACETATE 0.39 %;
SODIUM ACETATE 0.61 GM;
SODIUM ACETATE 0.61 GM/100ML;
SODIUM ACETATE 0.68 GM;
SODIUM ACETATE 10.8 GM/100ML;
SODIUM ACETATE 161 MG/100ML;
SODIUM ACETATE 2.7 GM;
SODIUM ACETATE 204 MG;
SODIUM ACETATE 218 MG;
SODIUM ACETATE 222 MG/100ML;
SODIUM ACETATE 27.2 MG;
SODIUM ACETATE 280 MG/100ML;
SODIUM ACETATE 295 MG/100ML;
SODIUM ACETATE 320 MG/100ML;
SODIUM ACETATE 330 MG/100ML;
SODIUM ACETATE 368 MG/100ML;
SODIUM ACETATE 431 MG;
SODIUM ACETATE 594 MG;
SODIUM ACETATE 594 MG/100ML;
SODIUM ACETATE 6.14 GM/100ML;
SODIUM ACETATE 610 MG/100ML;
SODIUM ACETATE 640 MG/100ML;
SODIUM ACETATE 68 MG;
SODIUM ACETATE 68 MG/100ML;
SODIUM ACETATE 9.25 GM/100ML;
SODIUM ACETATE 9.39 GM/100ML | - 3466. acid base balance
- [balance between acids and bases in body fluids; balance is achieved by the offset of the ingestion and production of acidic and basic material and by the amount of acidic and basic material metabolized and excreted by the body. ( CSP )] (UMLS (CSP) C0001117) =Organ or Tissue Function ;
|
- 3417. Acetic Acid, Zinc Salt, Dihydrate
- [A zinc salt of acetic acid essential for the synthesis of cholesterol, protein, and fats. Zinc plays an important role in the proper functioning of the immune system. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing as well as the release of vitamin A from the liver. It plays a role in the acuity of the senses of smell and taste and is required to maintain prostate reproductive health and insulin function. Zinc is also involved in the metabolism of carbohydrates. Zinc acetate is administered orally or parenterally as a nutritional supplement. ( NCI )] (UMLS (NCI) C0149368) =Organic Chemical; Pharmacologic Substance =acetate;
[TN405] ZINC;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=ZINC ACETATE SPRAY,TOP;
ZINC ACETATE 25 MG;
ZINC ACETATE 50 MG;
ZINC ACETATE 0.1 %;
ZINC ACETATE 1 % | - 3467. ACID BURN CORNEA/CONJUNC
- [ ] (UMLS (ICD9CM) C0161031) =Injury or Poisoning
|
- 3418. acetoacetate
- [salts and derivatives of acetoacetic acid. ( CSP )] (UMLS (CSP) C0000988) =Organic Chemical
| - 3468. acid fast bacteria
- [ ] (UMLS (CSP) C0597955) =Bacterium ;
|
- 3419. acetoacetyl coA thiolase
- [An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE. ( MSH )] (UMLS (CSP) C0001019) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 3469. Acid fast stain
- [Stain, Acid fast ( HL7V3.0 )] (UMLS (HL7) C0200974) =Laboratory Procedure =ObservationMethod;
|
- 3420. Acetobacter
- [A species of gram-negative bacteria of the family ACETOBACTERACEAE found in FLOWERS and FRUIT. Cells are ellipsoidal to rod-shaped and straight or slightly curved. ( MSH )] (UMLS (CSP) C0000990) =Bacterium
| - 3470. Acid fast stain, fluorochrome
- [Stain, Acid fast, fluorochrome ( HL7V3.0 )] (UMLS (HL7) C0200977) =Laboratory Procedure =ObservationMethod;
|
- 3421. Acetobacter aurantius
- [ ] (UMLS (CSP) C0599234) =Bacterium ;
| - 3471. Acid fast stain, Kinyoun's cold carbolfuchsin
- [Stain, Acid fast, Kinyoun's cold carbolfuchsin ( HL7V3.0 )] (UMLS (HL7) C0200976) =Laboratory Procedure =ObservationMethod;
|
- 3422. ACETONURIA
- [ ] (UMLS (ICD9CM) C0162275) =Sign or Symptom ;
| - 3472. Acid fast stain, Ziehl-Neelsen
- [Stain, Acid fast, Ziehl-Neelsen ( HL7V3.0 )] (UMLS (HL7) C0200975) =Laboratory Procedure =ObservationMethod;
|
- 3423. Acetophenazine Maleate
- (UMLS (NCI) C0304378) =Organic Chemical; Pharmacologic Substance =acetophenazine;
| - 3473. acid labile sulfide protein
- [ ] (UMLS (CSP) C0598735) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 3424. acetophenone
- [ ] (UMLS (CSP) C0050459) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid
| - 3474. acid maltase
- [An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4. ( MSH )] (UMLS (CSP) C0015278) =Amino Acid, Peptide, or Protein; Enzyme =O glycosidase;
|
- 3425. Acetothioamide
- [A synthetic, colorless crystalline solid that is soluble in water and ethanol. Thioacetamide is currently only used as a replacement for hydrogen sulfide in qualitative analysis. When heated to decomposition, it emits toxic fumes of nitrogen oxides and sulfur oxides. The primary routes of potential human exposure to thioacetamide are inhalation and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0039872) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 3475. acid maltase deficiency
- [autosomal recessively inherited glycogen storage disease caused by glucan 1,4-alpha-glucosidase deficiency; large amounts of glycogen accumulate in the lysosomes of skeletal muscle, heart, liver, spinal cord, and brain; three forms have been described: the infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy; the childhood form usually presents in the second year of life with proximal weakness and respiratory symptoms; the adult form consists of a slowly progressive proximal myopathy. ( CSP )] (UMLS (CSP) C0017921) =Disease or Syndrome =glycogen storage disease;
Lysosomal Storage Diseases, Nervous System |
- 3426. acetrizoate
- [ ] (UMLS (CSP) C0302288) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
| - 3476. acid phosphatase
- [An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2. ( MSH )] (UMLS (CSP) C0001109) =Amino Acid, Peptide, or Protein; Enzyme
|
- 3427. ACETRIZOATE SODIUM
- (UMLS (NCI) C0546847) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid
| - 3477. Acid phosphatase stain
- [Stain, Acid phosphatase ( HL7V3.0 )] (UMLS (HL7) C1261184) =Laboratory Procedure ;
=ObservationMethod;
|
- 3428. acetyl coA
- [participates in biosynthesis of fatty acids and sterols, fatty acid oxidation, metabolism of many amino acids, and acts as a biological acetylating agent. ( CSP )] (UMLS (CSP) C0001026) =Nucleic Acid, Nucleoside, or Nucleotide; Lipid; Biologically Active Substance
| - 3478. Acid Phosphatase, Prostate Gene
- [This gene plays a role in the regulation of prostate cell growth. ( NCI )] (UMLS (NCI) C1367456) ACPP;
ACPP Gene =Gene or Genome |
- 3429. acetyl coA carboxylase
- [A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2. ( MSH )] (UMLS (CSP) C0001022) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 3479. acid sphingomyelinase
- [ ] (UMLS (CSP) C0599122) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 3430. Acetyl Group Shuttle Pathway
- [Most of the energy derived from the oxidation of glucose is not extracted directly as ATP, but as reduced NADH that transfers high-energy electrons to the electron transport chain in the inner mitochondrial membrane. This NADH comes primarily from the Krebs cycle in the mitochondrial matrix and is therefore directly accessible to electron transport. NADH generated during glycolysis cannot reach the electron transport chain directly however and there is no direct mechanism for the transfer of NADH across the mitochondrial membrane. Instead shuttle mechanisms have evolved to move the energy of reduced NADH across the membrane in the form of other reduced molecules. One shuttle is the glycerophosphate shuttle and another is the malate-aspartate shuttle. The malate-aspartate shuttle occurs in mammalian tissues. First, oxaloacetate on the cytoplasmic side is reduced by NADH, creating malate and NAD+. Malate and the electrons it carries are transported into the mitochondria across the inner mitochondrial membrane, in exchange for alpha-ketoglutarate, which is transported out of the mitochondria. Once inside, the energy in malate is extracted again by reducing NAD+ to make NADH, regenerating oxaloacetate. This NADH is then free to transfer its high energy electrons to the electron transport chain. The oxaloacetate is transaminated with glutamate to make aspartate and alpha-ketoglutarate. Aspartate is returned to the cytosol by the aspartate-glutamate transporter, which moves glutamate into the mitochondria as it transports aspartate out. The overall result is that NADH is transported into the mitochondria, and can be used to generate 3 ATP per every NADH transported in from the cytosol, a very efficient process. (BioCarta) ( NCI )] (UMLS (NCI) C1510758) Shuttle for transfer of acetyl groups from mitochondria to the cytosol;
=Molecular Function ;
| - 3480. acid thiol ligase
- [Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1. ( MSH )] (UMLS (CSP) C0009227) =Amino Acid, Peptide, or Protein; Enzyme ;
=ligase;
|
- 3431. acetylation
- [formation of an acetyl derivative. ( CSP )] (UMLS (CSP) C0001038) =Molecular Function
| - 3481. Acidianus
- [A genus of facultatively anaerobic coccoid ARCHAEA, in the family SULFOLOBACEAE. Cells are highly irregular in shape and thermoacidophilic. Lithotrophic growth occurs aerobically via sulfur oxidation in some species. Distribution includes solfataric springs and fields, mudholes, and geothermically heated acidic marine environments. ( MSH )] (UMLS (CSP) C0597903) =Archaeon
|
- 3432. acetylcholine
- [neurotransmitter; in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. ( CSP )] (UMLS (CSP) C0001041) =Organic Chemical; Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine
| - 3482. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member B Protein
- [Encoded by human oncogene ANP32B Gene, 272-amino acid 31 kD PHAPI2 is similar to PHAPI. (Swiss-Prot, LocusLink, and NCI) ( NCI )] (UMLS (NCI) C0669086) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 3433. acetylcholine acetylhydrolase
- [An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7. ( MSH )] (UMLS (CSP) C0001044) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 3483. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member C Protein
- [Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. This protein is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, ANP32C protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and ANP32C. (LocusLink) ( NCI )] (UMLS (NCI) C1332092) Acidic Nuclear Phosphoprotein 32C;
ANP32C;
ANP32C Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 3434. Acetylcholine Receptor Inducing Activity
- [Neuregulin-1 was first cloned as "heregulin" and "neu differentiation factor" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer. Neuregulin-1 has also been studied as the "glial growth factor," which acts as a Schwann cell mitogen, and as "ARIA" (acetylcholine receptor inducing activity), a regulator of the expression of acetylcholine receptors. ( NCI )] (UMLS (NCI) C0626201) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 3484. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member D Protein
- [Encoded by human ANP32D Gene, 131-amino acid 14.8 kD PP32R2 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R1. PP32 can inhibit several types of cancers, including prostate and breast cancers. PP32R2 and PP32R1 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. PP32R2 is expressed in prostate cancer. (from SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1332094) Acidic Nuclear Phosphoprotein 32D;
ANP32D;
ANP32D Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 3435. Acetylcholine Receptor, Muscarinic, 4
- [Cholinergic Receptor, Muscarinic 4, encoded by the human CHRM4 gene, is a G protein-coupled receptor. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C1334833) Cholinergic Receptor, Muscarinic 4;
Cholinergic Receptor, Muscarinic, 4;
CHRM4;
CHRM4 Protein;
HM4;
Muscarinic Acetylcholine Receptor M4 =Amino Acid, Peptide, or Protein; Receptor | - 3485. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B Gene
- [This gene plays a regulatory role in the propagation of pro-apoptotic events. ( NCI )] (UMLS (NCI) C1332090) ANP32B;
ANP32B Gene;
=Gene or Genome ;
|
- 3436. Acetylcholinesterase Inhibitor
- (UMLS (NCI) C0001046) =Pharmacologic Substance
| - 3486. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C Gene
- [This gene is involved in tumor suppression. ( NCI )] (UMLS (NCI) C1332091) ANP32C;
ANP32C Gene;
=Gene or Genome ;
|
- 3437. acetylcysteine
- [N-acetyl derivative of cysteine; used as a mucolytic agent to reduce the viscosity of mucous secretions. ( CSP )] (UMLS (CSP) C0001047) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 3487. Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member D Gene
- [This gene plays a prominent role in tumor suppression. ( NCI )] (UMLS (NCI) C1332093) ANP32D;
ANP32D Gene;
=Gene or Genome ;
|
- 3438. ACETYLDIGITOXIN
- (UMLS (NCI) C0520442) =Steroid; Carbohydrate; Pharmacologic Substance
| - 3488. Acidic Coiled-Coil Protein 1
- [Encoded by human TACC1 Gene (TACC Family), TACC1 Protein is expressed during early embryogenesis as an 805-amino acid 87.8 kD protein rich in serine, proline, and acidic residues, with a 20-amino acid N-terminus rich in tryptophan, and containing two nuclear localization signals but no DNA- or RNA-binding domains. A 200-residue C-terminus with extensive alpha-helical segments is expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0907959) TACC1;
TACC1 Protein;
Transforming Acidic Coiled-Coil-Containing Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 3439. acetylene
- [ ] (UMLS (CSP) C0001052) =Organic Chemical
| - 3489. Acidic Coiled-Coil Protein 2
- [Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201) ( NCI )] (UMLS (NCI) C1309549) Anti Zuai-1 Protein;
AZU-1 Protein;
TACC2;
TACC2 Protein;
Transforming Acidic Coiled-Coil-Containing Protein 2;
Transforming, Acidic Coiled-Coil Containing Protein 2;
Transforming, Acidic Coiled-Coil-Containing Protein 2 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 3440. acetylmethadol
- [methadone analog. ( CSP )] (UMLS (CSP) C0025607) =Organic Chemical; Pharmacologic Substance ;
=METHADONE;
=LEVOMETHADYL | - 3490. Acidic Fibroblast Growth Factor
- [A modifier of endothelial cell migration and proliferation, Fibroblast Growth Factor 1 may be important in neovascularization. Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing. FGF1 causes the foregut endoderm to develop into the liver. The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4. Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis. FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide. (from OMIM 131220 and NCI) ( NCI )] (UMLS (NCI) C0079349) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 3441. Acetyltransferase
- [transfers acyl groups, forming either esters or amides. ( CSP )] (UMLS (NCI) C0001390) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 3491. Acidic Fibroblast Growth Factor Intracellular Binding Protein
- [Acidic fibroblast growth factor intracellular binding protein; may mediate the mitogenic properties associated with acidic FGF1. (Proteome Summary from LocusLink) ( NCI )] (UMLS (NCI) C1308850) FGF Intracellular Binding Protein;
FIBP;
Fibroblast Growth Factor (Acidic) Intracellular Binding Protein;
Fibroblast Growth Factor Intracellular Binding Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 3442. ACF
- [The Drosophila gene Acf1 encodes ATP-dependent chromatin assembly factor large subunit, a component of the chromatin assembly complex involved in chromatin assembly/disassembly. Acf1 contains a PHD-finger and is able to modulate the internucleosomal spacing of chromatin by an ATP-dependent mechanism. Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae. (from FlyBase 0027620 and NCI) ( NCI )] (UMLS (NCI) C1332006) ACF complex =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 3492. Acidification
- (UMLS (HL7) C1550102) =Therapeutic or Preventive Procedure ;
=Therapeutic Interventions;
◊ [The lowering of specimen pH through the addition of an acid ( HL7V3.0 )] (UMLS (HL7) C1551381) Laboratory Procedure ActSpecimenTreatmentCode; |
- 3443. ACFUCY
- (UMLS (NCI) C0050547) =Therapeutic or Preventive Procedure
| - 3493. Acidifying agents causing adverse effects in therapeutic use
- [ ] (UMLS (ICD9CM) C0261797) =Injury or Poisoning
|
- 3444. Achaete-Scute Complex Homolog-Like 1 Protein
- [Encoded by human ACSL1 Gene (bHLH/ASC Family), 236-aa 25 kDa transcription activation factor Achaete-Scute Complex-Like 1 Protein binds efficiently to the E box (5 prime-CANNTG-3 prime) as a heterodimer with other bHLH proteins, such as E12/E47. ACSL1 regulates commitment and differentiation of specific olfactory and autonomic neuronal lineages. ( NCI )] (UMLS (NCI) C0083344) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 3494. acidity
- [ ] (UMLS (CSP) C1330961) =Qualitative Concept; ;
|
- 3445. Achaete-Scute Complex-Like 1 (Drosophila) Gene
- [This gene plays a role in neural development and regulation of transcription. ( NCI )] (UMLS (NCI) C1332009) ASCL1;
ASCL1 Gene;
=Gene or Genome ;
| - 3495. acidity/alkalinity
- [the hydrogen ion concentration or pH. ( CSP )] (UMLS (CSP) C0920750) =Quantitative Concept =Chemical Properties;
|
- 3446. Achalasia
- [Failure of the smooth muscle fibers of the gastrointestinal tract to relax at any one point of junction of one part with another. ( NCI )] (UMLS (NCI) C1321756) =Finding ;
| - 3496. Acidophil Adenocarcinoma
- [A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes. ( NCI )] (UMLS (NCI) C0334311) =Neoplastic Process
|
- 3447. ACHALASIA & CARDIOSPASM
- [failure of normal relaxation of the lower esophageal sphincter associated with uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction and difficulty swallowing. ( CSP )] (UMLS (ICD9CM) C0014848) =Disease or Syndrome ;
=Disease of esophagus;
DYSKINESIA OF ESOPHAGUS | - 3497. Acidophil Adenoma
- [An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes. ( NCI )] (UMLS (NCI) C0001433) =Neoplastic Process
|
- 3448. Achard Syndrome
- (UMLS (NCI) C1332135) =Disease or Syndrome ;
| - 3498. Acidophilic Cell
- [A cell whose cytoplasm or its granules stain with acid dyes. ( NCI )] (UMLS (NCI) C0682546) =Cell
|
- 3449. Achenbach Syndrome
- (UMLS (NCI) C0473563) =Sign or Symptom
| - 3499. Acidoride
- (UMLS (NCI) C1263024) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 3450. Achilles
- (UMLS (HL7) C0001074) =Body Part, Organ, or Organ Component
| - 3500. acidosis
- [pathologic condition resulting from accumulation of acid or depletion of the alkaline reserve (bicarbonate) content of the blood and body tissues, and characterized by an increase in hydrogen ion concentration (decrease in pH). ( CSP )] (UMLS (CSP) C0001122) =Pathologic Function ;
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