UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
R R R- R0 R1 R2 R3 R4 RA RB RC RD RE RF RG RH RI RK RM RN RO RP RQ RR RS RT RU RV RW RX RY
selected terms: 2,734 page 23 of 28

2201. Rhinorrhea
(UMLS (NCI) C1260880) =Sign or Symptom ;
2251. Ribonucleotide Reductase M1 Polypeptide Gene
[This gene plays a role in the inhibition of cell migration, invasion, and metastasis. ( NCI )] (UMLS (NCI) C1335648) RRM1;
RRM1 Gene =Gene or Genome ;
2202. RHINOSCLEROMA
[A granulomatous disease affecting the nose and nasopharynx, usually ascribed to KLEBSIELLA RHINOSCLEROMATIS. It occurs in Egypt, eastern Europe, and Central and South America. ( MSH )] (UMLS (ICD9CM) C0035468) =Disease or Syndrome ;
=Klebsiella infection;
nasal disorder;
respiratory infection;
Skin Diseases, Bacterial
2252. Ribonucleotide Reductase M2 Polypeptide Gene
[This gene is involved in the promotion of cell cycle-specific gene expression. ( NCI )] (UMLS (NCI) C1335649) RRM2;
RRM2 Gene =Gene or Genome ;
2203. RHINOSCOPY
[ ] (UMLS (ICD9CM) C0189024) =Diagnostic Procedure
2253. Ribonucleotide Reductase Subunit
[Encoded by Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2), the M1 Chain and M2 Chain subunits compose Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI) ( NCI )] (UMLS (NCI) C1335783) =Amino Acid, Peptide, or Protein; Enzyme
2204. RHINOSPORIDIOSIS
[Chronic, localized granulomatous infection of mucocutaneous tissues, especially the NOSE, and characterized by HYPERPLASIA and the development of POLYPS. It is found in humans and other animals and is caused by the mesomycetozoean organism RHINOSPORIDIUM SEEBERI. ( MSH )] (UMLS (ICD9CM) C0035469) =Disease or Syndrome ;
=Fungal Infection;
2254. Ribonucleotide Reductase Subunit Gene
[Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2) encode the M1 Chain and M2 Chain subunits of Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI) ( NCI )] (UMLS (NCI) C1335784) =Gene or Genome ;
2205. rhinovirus
[genus of viruses comprising the common cold viruses. ( CSP )] (UMLS (CSP) C0035473) =Virus ;
=Picornaviridae;
2255. ribopolynucleotide
[ ] (UMLS (CSP) C0599163) =Nucleic Acid, Nucleoside, or Nucleotide ;
2206. RHINOVIRUS INFECT NOS
[ ] (UMLS (ICD9CM) C0153115) =Disease or Syndrome
2256. ribose
[aldopentose found in riboflavin and ribonucleic acid (RNA) as well as in free ribonucleosides and ribonucleotides. ( CSP )] (UMLS (CSP) C0035549) =Carbohydrate; Biologically Active Substance ;
=pentose;
=deoxyribose;
2207. Rhizidiovirus
[ ] (UMLS (CSP) C0599675) =Virus
2257. ribose phosphate
[ ] (UMLS (CSP) C0597412) =Carbohydrate ;
=pentose phosphate;
2208. Rhizobiaceae
[family of gram negative bacteria which are saprophytes, symbionts, or plant pathogens. ( CSP )] (UMLS (CSP) C0035474) =Bacterium ;
=bacteria;
=Agrobacterium;
2258. ribose phosphate pyrophosphokinase
[An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phosphate. EC 2.7.6.1. ( MSH )] (UMLS (CSP) C0035551) =Amino Acid, Peptide, or Protein; Enzyme ;
2209. Rhizobium
[A genus of gram-negative, aerobic, rod-shaped bacteria that produce nodules on the roots of leguminous plants. Members of this genus are common soil inhabitants. ( MSH )] (UMLS (CSP) C0035475) =Bacterium ;
2259. riboside
[any glycoside containing ribose as the sugar component. ( CSP )] (UMLS (CSP) C0597413) =Carbohydrate ;
=Glycoside;
2210. Rhizopoda
[ ] (UMLS (CSP) C0700131) =Invertebrate ;
2260. Ribosomal
[class of multicomponent structures found in all cells, in mitochondria, and chloroplasts with roles both in the genetic translation of transcripts and in the manufacture and secretion of the proteins. ( CSP )] (UMLS (NCI) C0035553) =Cell Component =cell component;
=polyribosome;
2211. Rhizoxin
[An anticancer drug isolated from a fungus. It is similar to the family of drugs called vinca alkaloids. ( NCI )] (UMLS (NCI) C0073184) =Organic Chemical; Pharmacologic Substance ;
2261. ribosomal protein
[diverse family of proteins found in ribosomes. ( CSP )] (UMLS (CSP) C0035552) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=nucleoprotein;
2212. RHO (GTP binding protein)
[A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47. ( MSH )] (UMLS (CSP) C0174045) =Amino Acid, Peptide, or Protein; Enzyme
2262. Ribosomal Protein L10 Gene
[This gene plays a role in protein biosynthesis. It is also involved in signal transduction. ( NCI )] (UMLS (NCI) C1335635) RPL10;
RPL10 Gene =Gene or Genome ;
2213. Rho-Associated, Coiled-Coil Containing Protein Kinase 1 Gene
[This gene is involved in the regulation of cell division, cytoskeletal remodeling and smooth muscle contraction. ( NCI )] (UMLS (NCI) C1335631) ROCK1;
ROCK1 Gene =Gene or Genome ;
2263. Ribosomal Protein L13 Gene
[This gene plays a role in transcription of ribosomal RNA which plays a role in protein synthesis. ( NCI )] (UMLS (NCI) C1335636) RPL13;
RPL13 Gene =Gene or Genome ;
2214. Rhodamine
(UMLS (NCI) C0600322) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
2264. Ribosomal Protein L19 Gene
[This gene plays a role in RNA binding and protein translation. ( NCI )] (UMLS (NCI) C1335637) RPL19;
RPL19 Gene =Gene or Genome ;
2215. Rhodamine stain
[Stain, Rhodamine ( HL7V3.0 )] (UMLS (HL7) C1294007) =Laboratory Procedure =ObservationMethod;
2265. Ribosomal Protein L29 Gene
[This gene is involved in RNA binding and protein synthesis. ( NCI )] (UMLS (NCI) C1335638) RPL29;
RPL29 Gene =Gene or Genome ;
2216. rhodanese
[An enzyme that catalyzes the transfer of the planetary sulfur atom of thiosulfate ion to cyanide ion to form thiocyanate ion. EC 2.8.1.1. ( MSH )] (UMLS (CSP) C0039949) =Amino Acid, Peptide, or Protein; Enzyme =sulfating enzyme;
2266. Ribosomal Protein L7A Gene
[This gene plays a role in protein biosynthesis. It is also involved in the inhibition of transactivation of transcription by nuclear hormone receptors. ( NCI )] (UMLS (NCI) C1335639) RPL7A;
RPL7A Gene =Gene or Genome ;
2217. Rhode Island
[A state in the northeastern United States. Its capital is Providence. ( NCI )] (UMLS (NCI) C0035487) =Geographic Area ;
2267. Ribosomal Protein L8 Gene
[This gene is involved in RNA binding and protein translation. ( NCI )] (UMLS (NCI) C1335640) RPL8;
RPL8 Gene =Gene or Genome ;
2218. Rhodesian Ridgeback
[The Rhodesian Ridgeback is a large, muscular hound. Its most unique characteristic is a clearly defined symmetrical ridge running the length of its back, formed by hair that grows in the opposite direction from the rest of its coat. The short, sleek coat comes in light to dark wheaten, sometimes with small white markings on the chest and feet. Height: 24-27 inches (61-69 cm.) Weight: 65-90 pounds (29-41 kg.) ( NCI )] (UMLS (NCI) C0324433) =Mammal
2268. Ribosomal Protein S19 Gene
[This gene plays a role in erythropoiesis and embryogenesis. ( NCI )] (UMLS (NCI) C1335641) RPS19;
RPS19 Gene =Gene or Genome ;
2219. Rhodesian trypanosome
[hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans; it is carried by Glossina pallidipes, G. morsitans and occasionally other species of game attacking tsetse flies. [NOTE: intend to propose TH alpha change from Trypanosoma brucei rhodesiense to Trypanosoma brucei. T. b. rhodesiense will become UF: term, nkg] ( CSP )] (UMLS (CSP) C0041219) =Invertebrate =Trypanosoma brucei;
2269. Ribosomal Protein S27 (Metallopanstimulin 1) Gene
[This gene is involved in DNA binding, RNA binding and protein synthesis. It also plays a role in regulation of cell proliferation. ( NCI )] (UMLS (NCI) C1335642) RPS27;
RPS27 Gene =Gene or Genome ;
2220. RHODESIAN TRYPANOSOMIAS
(UMLS (ICD9CM) C0041233) =Disease or Syndrome
2270. Ribosomal Protein S3 Gene
[This gene plays a role in DNA repair and positive regulation of apoptosis. ( NCI )] (UMLS (NCI) C1335643) RPS3;
RPS3 Gene =Gene or Genome ;
2221. Rhodnius
[A genus of the subfamily TRIATOMINAE. Rhodnius prolixus is a vector for TRYPANOSOMA CRUZI. ( MSH )] (UMLS (CSP) C0035494) =Invertebrate ;
2271. Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 Gene
[This gene is involved in the regulation of cell growth and proliferation. ( NCI )] (UMLS (NCI) C1335645) RPS6KB2;
RPS6KB2 Gene =Gene or Genome ;
2222. Rhodobacter
[A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats. ( MSH )] (UMLS (CSP) C0085503) =Bacterium ;
2272. Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 Gene
[This gene plays a role in the cellular signaling that occurs in response to mitogenic or stress stimuli. ( NCI )] (UMLS (NCI) C1419746) RPS6KA5;
RPS6KA5 Gene =Gene or Genome
2223. Rhodococcus
[A bacterial genus of the order ACTINOMYCETALES. ( MSH )] (UMLS (CSP) C0035496) =Bacterium ;
2273. Ribosomal Protein SA Gene
[This gene plays a role in several cellular processes including movement, signaling, and differentiation. ( NCI )] (UMLS (NCI) C1334330) RPSA;
RPSA Gene;
=Gene or Genome ;
2224. Rhodopseudomonas
[genus of gram negative, rod shaped, phototrophic bacteria found in aquatic environments; internal photosynthetic membranes are present as lamellae underlying the cytoplasmic membrane. ( CSP )] (UMLS (CSP) C0035497) =Bacterium ;
=bacteria;
2274. ribosomal RNA
[most abundant form of RNA; together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs; individual chains are conventionally designated by their sedimentation coefficients; in eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50 percent of the ribosome. ( CSP )] (UMLS (CSP) C0035701) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =Ribonucleic acid;
2225. rhodopsin
[photoreceptor protein found in retinal rods; it is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. ( CSP )] (UMLS (CSP) C0035499) =Amino Acid, Peptide, or Protein; Biologically Active Substance =membrane protein;
retina photosensitive pigment
2275. Ribosomal RNA-1
[Encoded by human RNR1 Gene, RNA Ribosomal 1 is a ribosomal RNA associated with proteins as structural components of a ribosome where polypeptides are produced by interacting with tRNA and mRNA. (From NCI) ( NCI )] (UMLS (NCI) C1335785) RNA, Ribosomal 1;
RNR1;
=Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance
2226. Rhodospirillales
[order of photosynthetic bacteria representing a physiological community of predominantly aquatic bacteria. ( CSP )] (UMLS (CSP) C0035501) =Bacterium ;
=bacteria;
=Rhodospirillum;
2276. Ribosome Subunit Gene
[Ribosome Subunit Genes encode Ribosomal Proteins, present in either the small or the large ribosomal subunit and involved in protein synthesis. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit. (NCI) ( NCI )] (UMLS (NCI) C1335786) =Gene or Genome ;
2227. Rhodospirillum
[from the Rhodospirillaceae, a genus of gram negative, spiral bacteria that possesses internal photosynthetic membranes; organisms divide by binary fission, are motile by means of polar flagella, and are found in aquatic environments. ( CSP )] (UMLS (CSP) C0035502) =Bacterium ;
=Rhodospirillales;
2277. ribosyltransferase
[ ] (UMLS (CSP) C0599091) =Amino Acid, Peptide, or Protein; Enzyme ;
2228. Rhodotorula
[A red yeast-like mitosporic fungal genus generally regarded as nonpathogenic. It is cultured from numerous sources in human patients. ( MSH )] (UMLS (CSP) C1095859) =Fungus ;
2278. Riboxamide
[An anticancer drug being studied to stop cell growth. ( NCI )] (UMLS (NCI) C0076656) =Organic Chemical; Pharmacologic Substance
2229. RHR heart reflex
[ ] (UMLS (CSP) C0597411) =Organ or Tissue Function ;
2279. rice
[annual cereal grass Oryza sativa and its edible starchy grain, which is the staple food of roughly one-half of the world's population. ( CSP )] (UMLS (CSP) C0035567) =Food ;
=grain;
Gramineae
2230. rhs
(UMLS (HL7) C1552834) =Idea or Concept =TableFrame;
2280. rice dwarf virus
[ ] (UMLS (CSP) C1176457) =Virus ;
2231. Rhynchophthirina
[ ] (UMLS (CSP) C1657307) =Invertebrate ;
2281. rice gall dwarf virus
[ ] (UMLS (CSP) C0599310) =Virus ;
2232. RHYTHM ELECTROCARDIOGRAM
[ ] (UMLS (ICD9CM) C0199556) =Diagnostic Procedure
2282. rice ragged stunt virus
[ ] (UMLS (CSP) C0599301) =Virus
2233. rhythm method
[ ] (UMLS (CSP) C0035513) =Therapeutic or Preventive Procedure
2283. Rich Text Format
(UMLS (HL7) C1548460) =Intellectual Product ;
=Subtype of referenced data;
2234. rib
[any of the paired elastic arches of bone that extend from the thoracic vertebrae toward the median line on the ventral aspect of the trunk, forming the major part of the thoracic skeleton; collectively called costae. ( CSP )] (UMLS (CSP) C0035561) =Body Part, Organ, or Organ Component ;
=Body Part;
bone
2284. Richter's Syndrome
[Transformation of chronic lymphocytic leukemia into aggressive non-Hodgkin's lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm. — 2004 ( NCI )] (UMLS (NCI) C0349631) =Neoplastic Process
2235. Rib Head
(UMLS (NCI) C0222806) =Body Part, Organ, or Organ Component
2285. RICIN
[proteinaceous phytotoxin from the castor oil plant, Ricinus communis; A chain has glycosidase activity which cleaves 28S rRNA, halting protein synthesis; extreme cytotoxicity makes ricin an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins. ( CSP )] (UMLS (NCI) C0035569) =Amino Acid, Peptide, or Protein; Hazardous or Poisonous Substance =phytotoxin;
2236. Rib Shaft
(UMLS (NCI) C0448161) =Body Part, Organ, or Organ Component
2286. Ricin A Chain
[One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI) ( NCI )] (UMLS (NCI) C0035570) =Amino Acid, Peptide, or Protein; Hazardous or Poisonous Substance
2237. Rib Tubercle
(UMLS (NCI) C0222809) =Body Location or Region
2287. ricinoleate
[ ] (UMLS (CSP) C0178834) =Lipid; Pharmacologic Substance ;
2238. RIB/STERNUM/CLAVIC X-RAY
[ ] (UMLS (ICD9CM) C0202819) =Diagnostic Procedure
2288. rickets
[disorder of calcium and phosphorus metabolism affecting bony structures, due to a variety of defects in vitamin D, calcium, and phosphorous homeostasis, including dietary deficiencies or malabsorption. ( CSP )] (UMLS (CSP) C0035579) =Disease or Syndrome ;
=Bone Diseases, Metabolic;
calcium metabolism disorder;
Unspecified vitamin D deficiency;
calcium disorder =familial hypophosphatemia in rickets;
renal rickets
2239. Riboazauracil
(UMLS (NCI) C0878257) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
2289. RICKETS, ACTIVE
(UMLS (ICD9CM) C0221468) =Disease or Syndrome ;
2240. Riboflavin Metabolism
[The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). [GOC:jl, http://www.indstate.edu/thcme/mw…g/vitamins.html] ( GO )] (UMLS (NCI) C1159440) Riboflavin Metabolism Pathway =Molecular Function
2290. RICKETS, LATE EFFECT
[ ] (UMLS (ICD9CM) C0154240) =Disease or Syndrome
2241. Ribonuclease
[Enzymes that catalyze the hydrolysis of RNA ( NCI )] (UMLS (NCI) C0035542) =Amino Acid, Peptide, or Protein; Enzyme ;
2291. Rickettsia
[in the Rickettsiaceae family, a genus of gram negative, aerobic, rod shaped bacteria often surrounded by a protein microcapsular layer and slime layer; the natural cycle of its organisms generally involves a vertebrate and an invertebrate host; species of the genus are the etiological agents of human diseases, such as typhus. ( CSP )] (UMLS (CSP) C0035583) =Rickettsia or Chlamydia ;
=Rickettsiales;
=Bartonella;
Prowazekia;
Rickettsia rickettsii;
2242. Ribonuclease Gene
[Ribonuclease Genes encode (Ribo)nucleases that specifically catalyze the cleavage of phosphate ester linkages in ribonucleic acids; endoribonucleases cleave internal bonds and exoribonucleases cleave bonds at termini. (NCI) ( NCI )] (UMLS (NCI) C1335782) =Gene or Genome ;
2292. Rickettsia rickettsii
[species of gram negative, aerobic bacteria that is the etiologic agent of Rocky Mountain spotted fever. ( CSP )] (UMLS (CSP) C0035588) =Rickettsia or Chlamydia ;
=Rickettsia;
2243. ribonuclease H
[specifically cleaves the RNA moiety of RNA:DNA hybrids. ( CSP )] (UMLS (CSP) C0085431) =Amino Acid, Peptide, or Protein; Enzyme =Endoribonuclease;
2293. Rickettsiaceae
[A family of small, gram-negative organisms, often parasitic in humans and other animals, causing diseases that may be transmitted by invertebrate vectors. ( MSH )] (UMLS (CSP) C0035591) =Rickettsia or Chlamydia ;
2244. ribonuclease P
[an RNA containing enzyme, essential for tRNA processing generates 5' terminal of mature tRNA molecule. ( CSP )] (UMLS (CSP) C0073243) =Amino Acid, Peptide, or Protein; Enzyme ;
=Endoribonuclease;
2294. rickettsial pox
[ ] (UMLS (CSP) C0035597) =Disease or Syndrome ;
2245. Ribonucleic acid
[ribonucleic acid; polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached; RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. ( CSP )] (UMLS (NCI) C0035668) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =Nucleic Acid;
=bacterial RNA;
double stranded RNA;
heterogeneous nuclear RNA;
Messenger RNA;
ribosomal RNA;
small nuclear RNA;
transfer RNA;
virus RNA;
complementary RNA;
catalytic RNA;
siRNA;
MicroRNA;
Post-Transcriptional Gene Silencing
2295. Rickettsiales
[order of gram negative proteobacteria; obligate intracellular parasites that cause a variety of diseases including typhus and Rocky Mountain spotted fever; organisms multiply in endothelial cells of small blood vessels, the resulting damage is the cause of the spotted appearance. ( CSP )] (UMLS (CSP) C0035596) =Rickettsia or Chlamydia ;
=bacteria;
=Cowdria;
Rickettsia
2246. ribonucleoprotein
[substance composed of both protein and ribonucleic acid. ( CSP )] (UMLS (CSP) C0035544) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=nucleoprotein;
=calreticulin;
RNA binding protein;
heterogeneous nuclear ribonucleoprotein;
2296. RICKETTSIOSES AND OTHER ARTHROPOD-BORNE DISEASES
[ ] (UMLS (ICD9CM) C0178242) =Disease or Syndrome
2247. ribonucleoside
[nucleoside in which the purine or pyrimidine base is combined with ribose. ( CSP )] (UMLS (CSP) C0035546) =Nucleic Acid, Nucleoside, or Nucleotide =nucleoside;
=adenosine;
cytidine;
guanosine;
inosine;
1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide;
4-Amino-7.beta.-D-ribofuranosyl-7H-pyrrolo(2, 3-d)pyrimidine;
tunicamycin;
UR;
adenosine;
cytidine;
formycin;
inosine;
1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide;
UR
2297. ridogrel
[ ] (UMLS (CSP) C0072926) =Organic Chemical; Pharmacologic Substance
2248. Ribonucleoside-Diphosphate Reductase M1 Chain
[Encoded by human RRM1 Gene, Ribonucleoside-Diphosphate Reductase M1 Chain is 1 of 2 ribonucleoside-diphosphate reductase subunits, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. RRM1 functions as a metastasis suppressor gene through induction of PTEN expression and PTEN-regulated pathways. (from Swiss-Prot, OMIM, LocusLink and NCI) ( NCI )] (UMLS (NCI) C1259395) Ribonucleotide Reductase Large Chain;
Ribonucleotide Reductase M1 Polypeptide;
Ribonucleotide Reductase R1 Subunit;
RRM1;
RRM1 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
2298. Riedel's Fibrosing Thyroiditis
(UMLS (NCI) C1335787) =Disease or Syndrome ;
2249. ribonucleotide
[nucleotide in which the purine or pyrimidine base is combined with ribose. ( CSP )] (UMLS (CSP) C0035548) =Nucleic Acid, Nucleoside, or Nucleotide =nucleotide;
=FAD;
flavin mononucleotide;
adenine nucleotide;
2299. RIFABUTIN
[broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. ( CSP )] (UMLS (NCI) C0140575) =Organic Chemical; Antibiotic ;
=antitubercular agent;
Rifamycin;
[AM900] ANTI-INFECTIVES, OTHER;
=RIFABUTIN 150 MG
2250. Ribonucleotide Reductase Inhibitor
[Substances that inhibit Ribonucleotide Reductase, an enzyme converting ribonucleoside diphosphates to deoxyribonucleotide diphosphate precursors for de novo DNA synthesis, causing inhibition of DNA synthesis and cell growth. ( NCI )] (UMLS (NCI) C1373035) Ribonucleotide Reductase Inhibitors;
=Pharmacologic Substance; Biologically Active Substance =Inhibitors, Nucleic Acid Synthesis;
2300. Rifadin
(UMLS (NCI) C0699924) =Organic Chemical; Pharmacologic Substance

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