- 2. (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid
- [The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04) ( NCI )] (UMLS (NCI) C0075615) =Organic Chemical; Pharmacologic Substance
| - 5. ZFP36L2
- [This gene plays a role in transcription and is postulated to regulate cellular responses to growth factors. ( NCI )] (UMLS (NCI) C1412825) ZFP36L2 Gene;
Zinc Finger Protein 36, C3H Type-Like 2 Gene =Gene or Genome |