- 1. XAF1
- [Widely expressed (highest in heart, ovary; lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI) ( NCI )] (UMLS (NCI) C1447833) XIAP-Associated Factor 1;
ZAP-1 =Amino Acid, Peptide, or Protein; Biologically Active Substance ; | |