- 1. T Cell
- [lymphocytes responsible for cell-mediated immunity, formed when lymphocytes circulate through the thymus gland and differentiate to thymocytes; when exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. ( CSP )] (UMLS (NCI) C0039194) =Cell =lymphocyte;
=helper T lymphocyte;
suppressor T lymphocyte;
CTL;
| - 14. T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant
- (UMLS (NCI) C1336551) T-Cell Prolymphocytic Leukemia, Sezary Cell-like Variant =Neoplastic Process ;
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- 2. T Cell Receptor Signaling Pathway
- [The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor. (BioCarta) ( NCI )] (UMLS (NCI) C1325934) =Molecular Function ;
| - 15. T-Cell Prolymphocytic Leukemia, Small Cell Variant
- (UMLS (NCI) C1336552) =Neoplastic Process ;
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- 3. T-Cell Activation
- [T-Cell Activation involves stimulation of T lymphocytes by receptor interaction with mitogens or cell surface-displayed antigens resulting in biosynthesis of lymphokines, cell proliferation, cell differentiation, and maturation to support immune activity. ( NCI )] (UMLS (NCI) C1155065) =Cell Function
| - 16. T-Cell Receptor Alpha
- [One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene. ( NCI )] (UMLS (NCI) C0087048) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 4. T-Cell and NK-Cell Neoplasm
- (UMLS (NCI) C1336554) T-Cell Neoplasm =Neoplastic Process ;
| - 17. T-Cell Receptor Beta
- [One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene. ( NCI )] (UMLS (NCI) C0087049) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 5. T-cell depletion
- [Treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow graft from a donor may reduce the chance of an immune reaction against the recipient's tissues. ( NCI )] (UMLS (NCI) C0677960) =Therapeutic or Preventive Procedure
| - 18. T-Cell Receptor Delta
- [One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene. ( NCI )] (UMLS (NCI) C0087050) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 6. T-Cell Immunodeficiency
- (UMLS (NCI) C1274233) =Disease or Syndrome
| - 19. T-Cell Receptor Gamma
- [One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene. ( NCI )] (UMLS (NCI) C0087051) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 7. T-Cell Leukemia Translocation Altered Gene
- [This gene is putatively involved in the regulation of cell growth. ( NCI )] (UMLS (NCI) C1336599) TCTA;
TCTA Gene =Gene or Genome ;
| - 20. T-Cell Receptor Gene
- [The T-cell antigen receptors consist of a heterodimer of integral membrane glycoproteins. Two distinct receptors exist, alpha/beta and gamma/delta. Alpha/beta receptors are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented in association with MHC gene products. Gamma/delta receptors, found in association with CD3, directly recognize proteins and non-proteinacious phospho-ligands. Alpha/beta and gamma/delta are non-covalently associated with CD3-gamma, -delta, -epsilon, and -zeta proteins, forming the TCR-CD3 complex, which activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. The genes for T-cell receptor subunits are encoded by distinct gene elements that are assembled by somatic rearrangement during T-cell development. Translocations and inversions of these loci are observed in human T-cell leukemias and lymphomas. ( NCI )] (UMLS (NCI) C0524889) =Gene or Genome ;
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- 8. T-Cell Leukemia Translocation Altered Gene Product
- [Ubiquitously expressed (highest in kidney) 103-aa 11-kDa T-Cell Leukemia Translocation Altered Gene Product is encoded by human TCTA Gene. (NCI) ( NCI )] (UMLS (NCI) C1336600) TCTA;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 21. T-Cell Receptor Interacting Molecule
- [Expressed in T cells (not B cells or monocytes) of the thymus, spleen, lymph nodes, and peripheral leukocytes by human TRIM Gene, 186-aa 29/30-kD disulfide-linked dimeric type III transmembrane adaptor phosphoprotein T-Cell Receptor Interacting Molecule contains an 8-aa extracellular domain (includes a Cys residue), a 19-aa transmembrane region and an intracellular domain with 4 potential phosphorylation sites likely involved in SH2-mediated interactions with signaling proteins. Associated with CD3E and CD3Z, TRIM modulates the TCR-CD3 complex in T lymphocytes. After T-cell activation, TRIM is tyrosine phosphorylated by Src kinases and associates with PIK3R1. (NCI) ( NCI )] (UMLS (NCI) C0756533) TCRIM;
TCR-Interacting Molecule;
TRIM;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 9. T-Cell Leukemia, Homeobox 1 Gene
- [This gene plays a role in transcriptional regulation and organogenesis. Translocations in the gene are associated with acute T-cell leukemia. ( NCI )] (UMLS (NCI) C0920270) TLX1;
TLX1 Gene;
=Gene or Genome | - 22. T-Cell Receptor, Alpha-Beta
- [T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules. ( MSH )] (UMLS (NCI) C0085247) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 10. T-Cell Leukemia/Lymphoma 1B Gene
- [This gene plays a role in the development of B cells. It is also involved in regulation of cell differentiation, growth and survival. ( NCI )] (UMLS (NCI) C1336598) TCL1B;
TCL1B Gene =Gene or Genome ;
| - 23. T-Cell Receptor, Gamma-Delta
- [T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3). ( MSH )] (UMLS (NCI) C0085246) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 11. T-Cell Lymphoma Invasion and Metastasis 1 Gene
- [This gene is plays a role in signal transduction, apoptosis and cytoskeletal remodeling. ( NCI )] (UMLS (NCI) C0812248) TIAM1;
TIAM1 Gene =Gene or Genome | - 24. T-Cell Rich/Histiocyte-Rich Large B-Cell Lymphoma
- (UMLS (NCI) C1321547) T-Cell/Histiocyte Rich Lymphoma =Neoplastic Process ;
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- 12. T-Cell Proliferation
- [An increase in the number of all, or specific subsets of, T-cells by cell growth and cell division during an immune response or during development. ( NCI )] (UMLS (NCI) C1155046) =Cell Function
| - 25. Tc element
- [first artificially produced element; technetium has the atomic symbol Tc, atomic number 43; all technetium isotopes are radioactive; technetium 99m has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. ( CSP )] (UMLS (CSP) C0039411) =Element, Ion, or Isotope ;
=Elements, radioactive;
radioisotope;
heavy metal;
[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS =Tc 99m;
Technetium Tc 99m Disofenin;
technetium Tc 99m teboroxime;
TECHNETIUM Tc 99m SODIUM PERTECHNETATE |
- 13. T-Cell Proliferation of Uncertain Malignant Potential
- (UMLS (NCI) C1336550) =Neoplastic Process ;
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