- 1. IAP
- [Retroviral-like intracisternal A particles. High copy number family of repeated elements in the mouse with a typical proviral organization. Expressed very early in mouse development (2-8 cell stage) and in transformed cells. Mutant alleles of various genes contain newly-integrated IAP genes. ( NCI )] (UMLS (NCI) C0600253) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
| - 3. IAP Family Protein
- [Encoded by Mammalian IAP Family Genes, conserved (Inhibitors of Apoptosis) IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI) ( NCI )] (UMLS (NCI) C0893445) IAP Protein;
Inhibitor of Apoptosis Protein; =Amino Acid, Peptide, or Protein; Biologically Active Substance |