[Product of the PTTG1 Gene. It is an anaphase-promoting complex substrate, involved in regulation of chromatid separation. Has effects on cell cycle regulation, cellular proliferation, and cellular transformation. It is a cytosolic, proline-rich protein with several SH3 sites and N-terminal basic and C-terminal acidic domains. ( NCI )] (UMLS (NCI) C1309143) ESP1-Associated Protein 1; PTTG1; PTTG1 Gene Product; Securin; =Amino Acid, Peptide, or Protein; Biologically Active Substance ;