TSG101

1. [This gene is involved in suppression of transcription and regulation of the cell cycle. It also plays a role in cell proliferation and survival. ( NCI )]
   UMLS (NCI) C1336678
   
   TSG101 Gene
   Tumor Susceptibility Gene 101 Gene
    

   Gene or Genome
   

2. [Encoded by human TSG101 Gene and expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, 390-amino acid 44 kD cytoplasmic Tumor Susceptibility Gene 101 Protein appears important for genomic stability and cell cycle regulation. A negative growth or differentiation regulator through p21 association and ubiquitin-conjugating enzyme homolog, TSG101 protein may be negative ubiquitin regulator or act in protein-ubiquitin conjugate removal. Nuclear TSG101 protein interacts with DMAP1; the coiled-coil domain interacts with cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. The ubiquitin enzyme-2 variant domain binds to ubiquitin and to the p6 domain PTAP motif of HIV-1 Gag protein. Mutations occur at high frequency in breast cancer during tumorigenesis or progression. (from Swiss-Prot, OMIM, and NCI) ( NCI )]
   UMLS (NCI) C1336837
   
   Tumor Susceptibility Gene 101 Protein
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance