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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
M M0 M1 M2 M4 M5 M7 M8 M9 MA MB MC MD ME MF MG MH MI MK ML MM MN MO MP MR MS MT MU MV MY
MO MOA MOB MOC MOD MOE MOF MOG MOH MOI MOK MOL MOM MON MOO MOP MOQ MOR MOS MOT MOU MOV MOW MOX MOY MOZ

MONO dgA RFB4

[An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor bean. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells. ( NCI )]
UMLS (NCI) C0935906
Monoclonal Antibody Mono-dgA-RFB4
 
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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