[Encoded by human MCM10 Gene, 98-kD Minichromosome Maintenance Protein 10 binds chromatin during S phase, dissociates in G(2), and is involved in eukaryotic genome replication initiation. MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. MCM10 interacts with ORC2 and with MCM2 and MCM6 of the hexameric MCM2-7 protein complex, a key component of the pre-replication complex and likely involved in formation of replication forks and in recruitment of replication factors. Involved in S phase progression, MCM10 may release MCM2-7 from the origin of replication triggering DNA replication. MCM10 likely binds chromatin after pre-RC assembly and before origin unwinding. (NCI) ( NCI )]
UMLS (NCI) C1334765Minichromosome Maintenance Protein 10
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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