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ISOSORBIDE
[An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. ( NCI )]
UMLS (NCI) C0022251- Carbohydrate
- Pharmacologic Substance
Relation/PAR: D glucitol
[CV250] ANTIANGINALS
[CV250] ANTIANGINALS
Relation/CHD: ISOSORBIDE DINITRATE
1,4:3,6-Dianhydro-D-glucitol 5-nitrate
ISOSORBIDE 45 %
1,4:3,6-Dianhydro-D-glucitol 5-nitrate
ISOSORBIDE 45 %
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