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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
IF IFA IFF IFI IFN IFO IFP

IFN-Gamma Receptor

[Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI) ( NCI )]
UMLS (NCI) C1334197
Interferon Gamma Receptor Complex
 
Amino Acid, Peptide, or Protein
Receptor


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