[Endothelin-2, encoded by the human EDN2 gene, is a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI) ( NCI )]
UMLS (NCI) C0079282 - Amino Acid, Peptide, or Protein
- Biologically Active Substance