BUB1

1. [This gene is a modulator of the mitotic spindle cell cycle checkpoint. ( NCI )]
   UMLS (NCI) C1332455
   
   BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog Gene
   BUB1 Gene
   
    

   Gene or Genome
   

2. [BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast), encoded by the human BUB1 gene, is a 120-kD serine/threonine protein kinase. This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI) ( NCI )]
   UMLS (NCI) C1332456
   
   BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog
   BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast)
   
    

   Amino Acid, Peptide, or Protein

   Enzyme