BNOS
[Encoded as 4 alternative isoforms by human NOS1 Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 1 binds FAD and FMN cofactors, contains a PDZ/DHR and a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes nitric oxide messenger from L-arginine. Neuronal NO displays neurotransmitter properties. N-truncated Isoform 3 possesses enzymatic activity. C-truncated isoform 4 is produced by frameshift exon insertion. NOS1 may interact with DLG4 and forms a ternary complex with CAPON and RASD1. NOS1 is localized beneath the sarcolemma in fast-twitch skeletal muscle fibers by associating with the dystrophin glycoprotein complex. The N-terminal PDZ domain of the neuronal NOS1 may participate in protein-protein interaction and target nNos to synaptic membranes. PIN inhibition may prevent NOS1 dimerization. (NCI) ( NCI )]
UMLS (NCI) C0907533Brain Nitric Oxide Synthase
Constitutive NOS
NC-NOS
Neuronal Nitric Oxide Synthase
Neuronal NOS
Nitric Oxide Synthase 1
NNOS
NOS Type I
NOS1
Constitutive NOS
NC-NOS
Neuronal Nitric Oxide Synthase
Neuronal NOS
Nitric Oxide Synthase 1
NNOS
NOS Type I
NOS1
- Amino Acid, Peptide, or Protein
- Enzyme
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