1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride

[The hydrochloride salt of an antimetabolite analog of the nucleoside pyrimidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. ( NCI )]

UMLS (NCI) C0771488

2'Deoxy-2',2'-Difluorocytidine, Hydrochloride
Difluorodeoxycytidine Hydrochloride
Gemcitabine Hydrochloride
GEMCITABINE HYDROCHLORIDE PREPARATION