- 2701. Adjustment reaction with predominant disturbance of other emotions
- [ ] (UMLS (ICD9CM) C0154584) =Mental or Behavioral Dysfunction
| - 2751. Admixture
- [1. The act of mixing; mixture. 2. The compound formed by mixing different substances together. 3. That which is mixed with anything. (ARTFL Project: Webster Dictionary, 1913) ( NCI )] (UMLS (NCI) C1510816) =Qualitative Concept
|
- 2702. Adjustment reaction with prolonged depressive reaction
- [ ] (UMLS (ICD9CM) C0154583) =Mental or Behavioral Dysfunction
| - 2752. Adnexal Carcinoma
- [A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma. ( NCI )] (UMLS (NCI) C0206697) =Neoplastic Process =adenocarcinoma;
Neoplasms, Adnexal and Skin Appendage |
- 2703. Adjuvant Chemotherapy
- [Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment. ( MSH )] (UMLS (NCI) C0085533) =Therapeutic or Preventive Procedure ;
| - 2753. Adnexal Mass
- (UMLS (NCI) C0149614) =Anatomical Abnormality
|
- 2704. Adjuvant P40
- [An insoluble fraction isolated from the bacterium Corynebacterium granulosum with potential cancer immunotherapeutic activity. As a non-specific immunostimulant, Corynebacterium granulosum P40 activates the reticulo-endothelial system, induces the production of certain cytokines, enhances macrophage activity, and potentiates a delayed-type hypersensitivity response when co-administered with an antigen. (NCI04) ( NCI )] (UMLS (NCI) C0050854) =Organic Chemical; Pharmacologic Substance
| - 2754. Adnexal Neoplasm of skin
- (UMLS (NCI) C0345988) =Neoplastic Process
|
- 2705. Adjuvant Protocol
- (UMLS (NCI) C1510810) Adjuvant Study;
Adjuvant Trial;
Adjuvant Trials;
=Research Activity | - 2755. adnexitis
- [Inflammation of the uterine appendages (ADNEXA UTERI) including infection of the FALLOPIAN TUBES (SALPINGITIS), the ovaries (OOPHORITIS), or the supporting ligaments (PARAMETRITIS). ( MSH )] (UMLS (CSP) C0001577) =Disease or Syndrome ;
|
- 2706. Adjuvant Therapy
- [(AD-joo-vant) Treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, or biological therapy. ( NCI )] (UMLS (NCI) C0677850) =Therapeutic or Preventive Procedure ;
| - 2756. ADOLES POSTURAL KYPHOSIS
- [ ] (UMLS (ICD9CM) C0158497) =Acquired Abnormality; Disease or Syndrome
|
- 2707. Adjuvanticity
- [the ability to nonspecifically stimulate the immune response. ( NCI )] (UMLS (NCI) C1510811) =Molecular Function
| - 2757. ADOLESCENCE GROWTH NEC
- [ ] (UMLS (ICD9CM) C0029575) =Finding
|
- 2708. ADL8-2698
- (UMLS (NCI) C0963856) =Organic Chemical; Pharmacologic Substance ;
| - 2758. Adolescent
- [A juvenile between the onset of puberty and maturity; in the state of development between puberty and maturity. (NCI) ( NCI )] (UMLS (NCI) C0205653) =Age Group ;
=Age categories;
|
- 2709. ADM INHAL NITRIC OXIDE
- [ ] (UMLS (ICD9CM) C1135443) Administration of inhaled nitric oxide =Therapeutic or Preventive Procedure
| - 2759. Adolescent and Children Mental Health
- [An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to mental and behavioral disorders in children and adolescents. Services may be provided to parents and family members of the patient in the form of conjoint, group, or individual therapy, and education and/or training. ( HL7V3.0 )] (UMLS (HL7) C1552522) =Intellectual Product ;
=Clinic/Center;
|
- 2710. ADM NEUROPROTECTIVE AGNT
- [ ] (UMLS (ICD9CM) C0994535) Administration of neuroprotective agent =Therapeutic or Preventive Procedure
| - 2760. Adolescent Medicine
- (UMLS (HL7) C1555745) =Professional or Occupational Group =Family Practice;
◊ (UMLS (HL7) C1555752) Professional or Occupational Group Internal Medicine; ◊ (UMLS (HL7) C1555827) Professional or Occupational Group Pediatrics; |
- 2711. Administerable Material
- [A material (player) that can be administered to an Entity (scoper). ( HL7V3.0 )] (UMLS (HL7) C1697853) =Idea or Concept =RoleClassPassive;
| - 2761. adopted
- [The name the person was given at the time of adoption. ( HL7V3.0 )] (UMLS (HL7) C1552574) =Idea or Concept =PersonNamePartChangeQualifier;
|
- 2712. Administered Component Designation
- [A name by which an Administered Component is known in a specific Context. Also a placeholder to track the usage of Administered Components by different Contexts. ( NCI )] (UMLS (NCI) C1510813) Designation;
=Conceptual Entity | - 2762. Adopted
- [Having been legally made a member of a family. ( NCI )] (UMLS (NCI) C0425382) =Finding
|
- 2713. AdministrableDrugForm
- (UMLS (HL7) C1698847) =Classification ;
=OrderableDrugForm;
=Drops;
SPRAY;
Puff;
Applicatorful;
Scoops | - 2763. adopted child
- [ ] (UMLS (CSP) C0337541) =Family Group
|
- 2714. Administration
- [Performing or possessing executive duties; acting as a supervisor or manager. ( NCI )] (UMLS (NCI) C0001554) =Occupational Activity ;
| - 2764. adopted child
- [A child taken into one's family through legal means and raised as one's own child. ( HL7V3.0 )] (UMLS (HL7) C1609059) =Intellectual Product ;
=Child;
CoverageRoleType =adopted son;
adopted daughter |
- 2715. Administration Device
- (UMLS (HL7) C0740039) =Medical Device ;
=HL7 Vocabulary Version 2.5;
=nebulizer;
AP;
PCA Pump;
Heparin Lock;
Buretrol;
IV Pump;
Metered Inhaler;
IV Soluset;
IPPB | - 2765. adopted daughter
- [The player of the role is a female child taken into a family through legal means and raised by the scoping person (parent) as his or her own child. ( HL7V3.0 )] (UMLS (HL7) C1610723) =Intellectual Product =adopted child;
|
- 2716. Administration Method
- (UMLS (HL7) C1547585) =Functional Concept =HL7 Vocabulary Version 2.5;
=Intravenous Push;
Intravenous Piggyback;
Chew;
Dissolve;
Dust;
Infiltrate;
Irrigate;
Insert;
Nebulized;
Perfuse;
Pain;
Soak;
Wash;
Wipe;
Shampoo;
| - 2766. Adopted Name
- (UMLS (HL7) C1549653) =Idea or Concept =Name type;
|
- 2717. Administration of botulism antitoxin
- [ ] (UMLS (ICD9CM) C0199791) =Therapeutic or Preventive Procedure
| - 2767. adopted son
- [The player of the role is a male child taken into a family through legal means and raised by the scoping person (parent) as his or her own child. ( HL7V3.0 )] (UMLS (HL7) C1608515) =Intellectual Product =adopted child;
|
- 2718. Administration of diphtheria toxoid
- [ ] (UMLS (ICD9CM) C0199806) =Therapeutic or Preventive Procedure
| - 2768. adoptive cell immunotherapy
- [A technique for enhancing cell-mediated immunity by either artificially increasing the number of specific immunocompetent cells through inoculation of ex-vivo expanded primarily activated cytotoxic lymphocytes, or genetically engineered lymphocytes with enhanced cytotoxic ability, or by altering tumor cells to make them more immunogenic. The concept does not refer to anticancer vaccines and immune modulation through the therapeutic use of cytokines, cell receptors, or other substances ( NCI )] (UMLS (CSP) C0079613) =Therapeutic or Preventive Procedure ;
|
- 2719. Administration of diphtheria-tetanus-pertussis, combined
- [ ] (UMLS (ICD9CM) C0199808) =Therapeutic or Preventive Procedure
| - 2769. Adoptive Transfer
- [Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE). ( MSH )] (UMLS (NCI) C0376518) =Therapeutic or Preventive Procedure
|
- 2720. Administration of intelligence test
- [standardized tests which measure a wide range of abilities, including verbal, numerical and social competence; includes Stanford-Binet test, Wechsler-Bellevue scale and Wechsler Intelligence scale. ( CSP )] (UMLS (ICD9CM) C0021705) =Diagnostic Procedure =Administration of psychologic test;
| - 2770. Adozelesin
- [An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the inhibition of DNA replication and induction of apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C0077640) =Organic Chemical; Pharmacologic Substance ;
|
- 2721. Administration of measles-mumps-rubella vaccine
- [ ] (UMLS (ICD9CM) C0199810) =Therapeutic or Preventive Procedure
| - 2771. ADP
- [data processing performed by automatic means; typically by computer. ( CSP )] (UMLS (CSP) C0004374) =Machine Activity ;
|
- 2722. Administration of other antitoxins
- [ ] (UMLS (ICD9CM) C0178222) =Therapeutic or Preventive Procedure
| - 2772. ADP ribosylation
- [covalent ligation of a protein or other substrate to the ADP-ribose (adenine-ribose-P-P-ribose) obtained by splitting off the nicotinamide from NADH; important in polynucleotide biosynthesis, G protein systems, and pertussis and cholera toxin actions. ( CSP )] (UMLS (CSP) C0596043) =Phenomenon or Process ;
=Glycosylation;
|
- 2723. Administration of poliomyelitis vaccine
- [ ] (UMLS (ICD9CM) C0178210) =Therapeutic or Preventive Procedure
| - 2773. ADP ribosyltransferase
- [Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains. ( MSH )] (UMLS (CSP) C0085748) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2724. Administration of psychologic test
- [standardized tests designed to measure abilities, as in intelligence, aptitude, and achievement tests, or to evaluate personality traits. ( CSP )] (UMLS (ICD9CM) C0033905) =Diagnostic Procedure ;
= ;
=Administration of intelligence test;
neuropsychological test;
personality test;
Rorschach test;
dexamethasone suppression test;
lie detector;
behavior test;
| - 2774. ADR
- [Indicates that the observation is of an unexpected negative occurrence in the subject suspected to result from the subject's exposure to one or more agents. Observation values would be the symptom resulting from the reaction. ( HL7V3.0 )] (UMLS (NCI) C0559546) =Finding =ObservationType;
|
- 2725. Administration of tetanus antitoxin
- [ ] (UMLS (ICD9CM) C0199789) =Therapeutic or Preventive Procedure
| - 2775. ADR-529
- (UMLS (NCI) C0733405) =Organic Chemical; Pharmacologic Substance
|
- 2726. Administration of tetanus toxoid
- [ ] (UMLS (ICD9CM) C0199807) =Therapeutic or Preventive Procedure
| - 2776. ADR-529/ASP/DOX/MP/MTX/PRED/VCR
- (UMLS (NCI) C0338303) =Therapeutic or Preventive Procedure
|
- 2727. AdministrationDetectedIssueCode
- [Administration of the proposed therapy may be inappropriate or contraindicated as proposed ( HL7V3.0 )] (UMLS (HL7) C1697987) =Intellectual Product =ActSuppliedItemDetectedIssueCode;
=Dosage problem;
Compliance Alert;
TimingDetectedIssueCode;
AppropriatenessDetectedIssueCode;
DrugActionDetectedIssueCode;
| - 2777. ADR-529/ASP/DOX/MP/PRED/VCR
- (UMLS (NCI) C0338302) =Therapeutic or Preventive Procedure
|
- 2728. AdministrationMedicalDevice
- [A device intended to administer a substance to a subject ( HL7V3.0 )] (UMLS (HL7) C1698718) =Intellectual Product ;
=MedicalDevice;
=Applicator;
Pump;
Inhaler;
InjectionMedicalDevice;
| - 2778. ADR-529/BLEO/CTX/DOX/PRED/VCR/VP-16
- (UMLS (NCI) C0677847) =Therapeutic or Preventive Procedure ;
|
- 2729. Administrative Component
- (UMLS (ICPC) C0497529) (Administrative Component; (194); (115); (116); (104); (105); (106); (108); (119); (133); (130); (122); (123)) =Intellectual Product =International Classification of Primary Care; =Administratieve verrichting
| - 2779. ADR-529/BLEO/DOX/VCR/VP-16
- (UMLS (NCI) C0392942) =Therapeutic or Preventive Procedure ;
|
- 2730. administrative personnel
- [individuals responsible for the development of policy and supervision of the execution of plans and functional operations. ( CSP )] (UMLS (CSP) C0001568) =Professional or Occupational Group ;
| - 2780. ADR-529/CTX/DOX/5-FU
- (UMLS (NCI) C0279446) =Therapeutic or Preventive Procedure
|
- 2731. administrative price or handling fee
- (UMLS (HL7) C1549764) =Quantitative Concept =Price type;
| - 2781. ADR-529/CTX/DOX/VCR
- (UMLS (NCI) C0279414) =Therapeutic or Preventive Procedure
|
- 2732. Administrative procedure
- (UMLS (ICPC) C0184665) (Administrative procedure; administrazio tramitea; Administrativ procedure; Administratieve verrichting; HALLINNOLLISET TOIMENPITEET; Contact administratif; Administrative Massnahme; (108); adminisztrativ tevekenyseg; Procedura amministrativa; ADMINISTRATIV KONTAKT; Procedimento administrativo; Procedimiento administrativo; ADMINISTRATIVA ATGARDER) =Health Care Activity ;
=Administrative Component; | - 2782. ADR-529/DOX
- (UMLS (NCI) C0281254) =Therapeutic or Preventive Procedure ;
|
- 2733. Administrative Sex
- (UMLS (HL7) C1611290) =Organism Attribute =HL7 Vocabulary Version 2.5;
=F;
Human, Male;
Ambiguous;
Not applicable;
Other;
Unknown | - 2783. ADR-529/DOX/G-CSF/TAX
- (UMLS (NCI) C0338281) =Therapeutic or Preventive Procedure ;
|
- 2734. Administrative Supplement
- [Mechanism to fund current awardees whose research is going better than expected or who are poised to test new ideas. ( NCI )] (UMLS (NCI) C1510814) =Governmental or Regulatory Activity
| - 2784. ADR-529/DOX/GM-CSF
- (UMLS (NCI) C0279104) =Therapeutic or Preventive Procedure
|
- 2735. Administrative Supplements to Research Grants
- [These provide administrative supplements to existing NIH research grants for the purpose of 1) promote reentry into biomedical and behavioral research careers 2) promote the recruitment of individuals with disabilities into biomedical research careers and 3) attract underrepresented minorities into biomedical and behavioral research. ( NCI )] (UMLS (NCI) C1510815) =Governmental or Regulatory Activity
| - 2785. ADR-529/DOX/MP/MTX/PRED/VCR
- (UMLS (NCI) C0338305) =Therapeutic or Preventive Procedure
|
- 2736. AdministrativeContactRoleType
- [A contact role used for business and/or administrative purposes. ( HL7V3.0 )] (UMLS (HL7) C1698902) =Intellectual Product ;
=ContactRoleType;
=organizational contact;
Billing Contact;
Payor Contact | - 2786. ADR-529/DOX/TAX
- (UMLS (NCI) C0338280) =Therapeutic or Preventive Procedure ;
|
- 2737. AdministrativeGender
- [The gender of a person used for adminstrative purposes (as opposed to clinical gender) ( HL7V3.0 )] (UMLS (HL7) C1550327) =Organism Attribute =CodeSystem;
=F;
Human, Male;
Undifferentiated | - 2787. ADRA1A
- [Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI) ( NCI )] (UMLS (NCI) C0389726) =Amino Acid, Peptide, or Protein; Receptor
|
- 2738. AdministrativeLocationRoleType
- (UMLS (HL7) C1701923) =Intellectual Product ;
=RoleCode;
| - 2788. ADRA1A
- [This gene plays a regulatory role in the growth and proliferation of several cell types. ( NCI )] (UMLS (NCI) C1332026) ADRA1A Gene;
Adrenergic, Alpha-1A-, Receptor Gene;
=Gene or Genome ;
|
- 2739. Administrator
- (UMLS (HL7) C1610729) =Intellectual Product =Registered Nurse;
| - 2789. ADRA1B
- [Encoded by human protooncogene ADRA1B Gene (GPCR1 Family), 519-aa 56.8-kD Alpha-1B Adrenergic Receptor is a Gq/11-associated integral membrane protein that activates mitogenic PI-calcium second messenger responses and controls vascular tone and systolic blood pressure. ( NCI )] (UMLS (NCI) C0291339) =Amino Acid, Peptide, or Protein; Receptor
|
- 2740. ADMINISTRTVE ENCOUNT NEC
- [ ] (UMLS (ICD9CM) C0260847) =Finding
| - 2790. ADRA1B
- [This gene is involved in the induction of neoplastic transformation and receptor signaling. ( NCI )] (UMLS (NCI) C1332027) ADRA1B Gene;
Adrenergic, Alpha-1B-, Receptor Gene;
=Gene or Genome ;
|
- 2741. ADMINISTRTVE ENCOUNT NOS
- [ ] (UMLS (ICD9CM) C0260849) =Finding
| - 2791. ADRA2A
- [Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. These receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. Alpha-2A-adrenergic receptor is encoded by the ADRA2A gene. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. (From LocusLink, Swiss_Prot and NCI) ( NCI )] (UMLS (NCI) C0391398) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 2742. Admission
- [The condition of being allowed to enter; the activity of admitting someone to something. ( NCI )] (UMLS (NCI) C0809949) =Health Care Activity ;
| - 2792. ADRA2A
- [This gene plays a role in the regulation of neurotransmitter release from nerves and neurons in the central nervous system. ( NCI )] (UMLS (NCI) C1332028) ADRA2A Gene;
Adrenergic, Alpha-2A-, Receptor Gene;
=Gene or Genome ;
|
- 2743. Admission Level of Care Code
- (UMLS (HL7) C1547813) =Intellectual Product =HL7 Vocabulary Version 2.5;
=Acute;
Chronic;
Comatose;
Critical;
Moribund;
Improved | - 2793. ADRA2B
- [Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The alpha2B subtype, encoded by the ADRA2B gene is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (From LocusLink) ( NCI )] (UMLS (NCI) C0540641) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 2744. Admission Type
- (UMLS (HL7) C1550330) =Classification =HL7 Vocabulary Version 2.5;
=Accident;
Elective;
Newborn (Birth in healthcare facility);
Routine;
Urgent;
Emergency;
Labor and Delivery | - 2794. ADRA2B
- [This gene is involved in transcriptional regulation and G protein-coupled receptor signal transduction. ( NCI )] (UMLS (NCI) C1332029) ADRA2B Gene;
Adrenergic, Alpha-2B-, Receptor Gene;
=Gene or Genome ;
|
- 2745. Admit Source
- (UMLS (HL7) C1550339) =Classification =HL7 Vocabulary Version 2.5;
=Physician referral;
Clinic referral;
HMO referral;
Transfer from a hospital;
Transfer from a skilled nursing facility;
Transfer from another health care facility;
Emergency room;
Court/law enforcement;
Data Not Available | - 2795. ADRB1
- [Encoded by human ADRB1 Gene (GPCR1 Family), 477-aa 51-kDa conserved Beta-1-Adrenergic Receptor is an integral membrane protein receptor for catecholamine epinephrine and norepinephrine neurotransmitters that activates adenylate cyclase through G protein action. ADRB1 phosphorylation by beta-adrenergic receptor kinase mediates receptor desensitization. Agonist and antagonist drugs selective for beta-1 receptors have important applications in clinical medicine. (NCI) ( NCI )] (UMLS (NCI) C0001642) =Amino Acid, Peptide, or Protein; Receptor
|
- 2746. Admitted as an inpatient to this hospital
- (UMLS (HL7) C1548210) =Idea or Concept =Discharge Disposition;
| - 2796. ADRB2
- [Encoded by human ADRB2 Gene (GPCR Family), Beta-2 Adrenergic Receptor directly associates with one of its effectors, class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. This signaling complex assembly ensures specific and rapid signaling by this G protein-coupled receptor that stimulates adenylyl cyclase activity. Polymorphisms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. (From LocusLink) ( NCI )] (UMLS (NCI) C0001643) =Amino Acid, Peptide, or Protein; Receptor
|
- 2747. admitter
- [The practitioner who is responsible for admitting a patient to a patient encounter. ( HL7V3.0 )] (UMLS (HL7) C1555323) =Professional or Occupational Group =ParticipationAncillary;
| - 2797. ADRB2
- [This gene is involved in maintaining the integrity and rate of G protein-coupled receptor signal transduction. ( NCI )] (UMLS (NCI) C1367657) ADRB2 Gene;
Adrenergic, Beta-2-, Receptor, Surface Gene =Gene or Genome ;
|
- 2748. Admitting
- (UMLS (HL7) C1546484) =Idea or Concept =Diagnosis Type;
◊ (UMLS (HL7) C1547428) Idea or Concept Provider role; | - 2798. ADRBK1
- [Beta-adrenergic receptor kinase 1 (ADRBK1), encoded by the ADRBK1 gene, phosphorylates the beta-2-adrenergic receptor and mediates agonist-specific desensitization observed at high agonist concentrations. ADRBK1, an ubiquitous cytosolic enzyme, translocates from the cytosol to the plasma membrane upon agonist stimulation and specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by ADRBK1, an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy. (From LocusLink) ( NCI )] (UMLS (NCI) C0753114) BARK1;
Beta-Adrenergic Receptor Kinase 1;
BETA-ARK1;
Beta-ARK-1;
EC 2.7.1.126;
G-Protein Coupled Receptor Kinase 2;
GRK2;
=Amino Acid, Peptide, or Protein; Enzyme; Receptor |
- 2749. admitting diagnosis
- [Admitting diagnosis are the diagnoses documented for administrative purposes as the basis for a hospital admission. ( HL7V3.0 )] (UMLS (HL7) C1555318) =Intellectual Product =ObservationDiagnosisTypes;
| - 2799. ADRBK1
- [This gene is involved in signal transduction. ( NCI )] (UMLS (NCI) C1366490) ADRBK1 Gene;
Adrenergic, Beta, Receptor Kinase 1 Gene =Gene or Genome |
- 2750. admitting physician
- [The physician responsible for the admission of a patient to a hospital or other inpatient health institution. The admitting physician evaluates patients, makes admitting decisions and assesses diagnostic and treatment plans. ( NCI )] (UMLS (HL7) C1550497) =Professional or Occupational Group =ParticipationFunction;
| - 2800. ADRBK2
- [Adrenergic, Beta, Receptor Kinase 2 (ADRBK2), encoded by the ADRBK2 gene, specifically phosphorylates the agonist-occupied and -activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK2 regulates desensitization of G protein-coupled receptors. Overall, the ADRBK2 enzyme has 85% amino acid similarity with ADRBK1, with the protein kinase Catalytic Domain Having 95% Similarity. (From Locuslink) ( NCI )] (UMLS (NCI) C0285499) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
|
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