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1. (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic Acid, 4-(Nitrooxy)butyl Ester
(UMLS (NCI) C0968094) Nitrosulindac;
NO-Releasing Sulindac;
=Organic Chemical; Pharmacologic Substance ;
51. ZI
[A country in Southern Africa, between South Africa and Zambia. (NCI) ( NCI )] (UMLS (NCI) C0043476) =Geographic Area
2. (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid
[The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04) ( NCI )] (UMLS (NCI) C0075615) =Organic Chemical; Pharmacologic Substance
52. Ziac
(UMLS (NCI) C0252287) =Organic Chemical; Pharmacologic Substance ;
3. (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole Mononitrate
[The nitrate salt form of oxiconazole, a synthetic imidazole derivative with an antifungal activity. Oxiconazole nitrate inhibits cytochrome P-450 dependent C-14 alpha demethylation of fungal sterols, which results in accumulation of 14 alpha-methyl sterols, inhibition of ergosterol synthesis, disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. ( NCI )] (UMLS (NCI) C0142160) =Organic Chemical; Pharmacologic Substance
53. Ziba-Rx
(UMLS (NCI) C0724477) =Amino Acid, Peptide, or Protein; Antibiotic
4. (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
[The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, thereby inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma as well as in other cancers that express high levels of protein kinase C. ( NCI )] (UMLS (NCI) C0079589) =Organic Chemical; Pharmacologic Substance =1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene;
[A drug used in the treatment of chronic pain. ( NCI )] (UMLS (NCI) C0211011) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
5. (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
[An anticancer drug that belongs to the family of drugs called antiestrogens. Toremifene blocks the effect of the hormone estrogen in the body. It may help control some cancers from growing, and it may delay or reduce the risk of cancer recurrence. ( NCI )] (UMLS (NCI) C0076836) =Organic Chemical; Pharmacologic Substance ;
[AN500] ANTINEOPLASTIC HORMONES =(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)
55. Zidometacin
(UMLS (NCI) C0078765) =Organic Chemical; Pharmacologic Substance ;
6. (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)
[The citrate salt of a nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. (NCI04) ( NCI )] (UMLS (NCI) C0117339) =Organic Chemical; Pharmacologic Substance ;
56. ZIFT
[A technique in assisted reproduction (REPRODUCTIVE TECHNIQUES, ASSISTED) consisting of hormonal stimulation of the ovaries, follicular aspiration of preovulatory oocytes, in-vitro fertilization, and intrafallopian transfer of zygotes at the pronuclear stage (before cleavage). ( MSH )] (UMLS (CSP) C0162779) =Therapeutic or Preventive Procedure ;
7. (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
[A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer. ( NCI )] (UMLS (NCI) C0038792) =Organic Chemical; Pharmacologic Substance =Indenes;
57. Zinacef
(UMLS (NCI) C0043480) =Organic Chemical; Antibiotic ;
8. (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid
[A drug that is being studied in the treatment and prevention of cancer. It has been shown to cause apoptosis (cell death) in cancerous and precancerous cells by acting through a group of cellular enzymes called cGMP phosphodiesterases. ( NCI )] (UMLS (NCI) C0075616) =Organic Chemical; Pharmacologic Substance
58. Zinc Chromate
[A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Zinc chromate is highly corrosive and is a strong oxidizing agent. This substance is used as a corrosion inhibitor, metal conditioner and is used in paints, varnishes and oil colors. Zinc chromate primarily affects the lungs causing shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05) ( NCI )] (UMLS (NCI) C0078775) =Hazardous or Poisonous Substance; Inorganic Chemical ;
9. (Z,Z)-9,12-Octadecadienoic Acid
[A polyunsaturated essential fatty acid found mostly in plant oils. It is used in the biosynthesis of prostaglandins and cell membranes. ( NCI )] (UMLS (NCI) C0023749) =Lipid; Pharmacologic Substance; Biologically Active Substance =Linoleic Acids;
Inactive Ingredient Preparations =Lecithin 420 MG Oral Capsule
59. zinc finger
[The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2+ is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heterodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA. ( NCI )] (UMLS (CSP) C0080347) =Spatial Concept ;
10. 2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine
(UMLS (NCI) C0067934) =Organic Chemical; Biologically Active Substance
60. Zinc Finger Protein 217
[Encoded by human oncogene ZNF217 Gene (Kruppel Family), 1048-amino acid 115 kD Zinc Finger Protein 217 is a widely expressed transcription factor having a DNA-binding domain (eight C2H2-type zinc fingers) and a proline-rich transcription activation domain. ZNF217 is over expressed in cell lines and in tumors in which the gene is amplified. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )] (UMLS (NCI) C1447657) ZNF217;
ZNF217 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance
11. 7-((4Z)-3-(Aminomethyl)-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)naphthyridine-3-carboxylic Acid Monomethanesulfonate
[The mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. This fluoroquinolone exerts an enhanced spectrum of activity against gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, in addition to its activity against gram-negative bacteria. ( NCI )] (UMLS (NCI) C1321744) Gemifloxacin Mesylate;
Unclassified Ingredients =GEMIFLOXACIN MESYLATE 320 MG
61. Zinc Finger Protein 217 Gene
[This gene plays a role in transcriptional activation and DNA binding interactions. ( NCI )] (UMLS (NCI) C1421705) ZNF217;
ZNF217 Gene =Gene or Genome
12. Z DNA
[zigzag left-handed conformer of DNA; naturally occurring Z DNA is sensitive to a different set of enzymes and binding proteins than "normal" B DNA, and is thought to play an important role in genetic regulation. ( CSP )] (UMLS (CSP) C0043442) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =deoxyribonucleic acid;
62. Zinc Sulfide
(UMLS (NCI) C0078795) =Pharmacologic Substance; Inorganic Chemical
13. Z-DNA Binding Protein
[A protein which specifically binds to Z DNA ( NCI )] (UMLS (NCI) C1337041) =Amino Acid, Peptide, or Protein; Biologically Active Substance
(UMLS (NCI) C0078808) =Organic Chemical; Pharmacologic Substance
14. ZA
[A country in Southern Africa, east of Angola. (NCI) ( NCI )] (UMLS (NCI) C0043445) =Geographic Area
64. Zinecard
(UMLS (NCI) C0728750) =Organic Chemical; Pharmacologic Substance ;
15. Zabiciprilat
(UMLS (NCI) C0165809) =Organic Chemical; Pharmacologic Substance
(UMLS (NCI) C0699544) =Organic Chemical; Pharmacologic Substance
16. Zaditen
(UMLS (NCI) C0878100) =Organic Chemical; Pharmacologic Substance
66. Zipeprol
(UMLS (NCI) C0078811) =Organic Chemical; Pharmacologic Substance
17. Zaleplon
[A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with the gamma-aminobutyric acid (GABA) -A receptor, thereby affecting the chloride channel ionophore complex and potentiating the inhibitory effects of GABA. In addition, zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding. ( NCI )] (UMLS (NCI) C0251504) =Organic Chemical; Pharmacologic Substance ;
67. Ziprasidone Mesylate
[The mesylate salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone mesylate functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone mesylate also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone mesylate exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. ( NCI )] (UMLS (NCI) C1170754) =Organic Chemical; Pharmacologic Substance
(UMLS (NCI) C0386392) =Organic Chemical; Pharmacologic Substance ;
68. zirconium
[rare metallic element, atomic symbol Zr, atomic number 40. ( CSP )] (UMLS (CSP) C0043506) =Element, Ion, or Isotope =heavy metal;
19. Zanosar
(UMLS (NCI) C0724450) =Carbohydrate; Antibiotic ;
69. Zithromax
(UMLS (NCI) C0678143) =Organic Chemical; Antibiotic ;
20. Zantac
(UMLS (NCI) C0592278) =Organic Chemical; Pharmacologic Substance
70. ZK 36374
(UMLS (NCI) C0733549) =Eicosanoid; Pharmacologic Substance ;
21. ZAP70
[This gene is involved in tyrosine phosphorylation and T-cell activation. ( NCI )] (UMLS (NCI) C1421567) ZAP70 Gene;
Zeta-Chain (TCR) Associated Protein Kinase 70kDa Gene =Gene or Genome
71. zlib
[A compressed data format that also uses the deflate algorithm. Specified as RFC 1950 [] ( HL7V3.0 )] (UMLS (HL7) C1550698) =Intellectual Product =CompressionAlgorithm;
22. Zaprinast
(UMLS (NCI) C0065432) =Organic Chemical; Pharmacologic Substance ;
72. ZM 252868
(UMLS (NCI) C0540034) =Organic Chemical; Pharmacologic Substance ;
23. Zardaverine
(UMLS (NCI) C0085049) =Organic Chemical; Pharmacologic Substance ;
73. zocor
[ ] (UMLS (CSP) C0678181) =Organic Chemical; Pharmacologic Substance
24. Zarnestra
(UMLS (NCI) C1174783) =Organic Chemical; Pharmacologic Substance ;
74. Zofran
(UMLS (NCI) C0206046) =Organic Chemical; Pharmacologic Substance
25. Zarontin
(UMLS (NCI) C0699966) =Organic Chemical; Pharmacologic Substance ;
75. Zoledronic Acid
[A synthetic imidazole bisphosphonate analog of pyrophosphate with bone-resorption-inhibiting activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This drug also inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. Zoledronic acid's inhibitory effects on osteoclast-mediated bone resorption result in decreased bone turnover and stabilization of the bone matrix, two effects that contribute to the analgesic properties associated with painful osteoblastic lesions. The drug also reduces serum calcium concentrations associated with hypercalcemia. ( NCI )] (UMLS (NCI) C0257685) =Organophosphorus Compound; Pharmacologic Substance =ZOLEDRONIC;
Unclassified Ingredients =ZOLEDRONIC ACID 4 MG
26. Zaroxolyn
(UMLS (NCI) C0701383) =Organic Chemical; Pharmacologic Substance
(UMLS (NCI) C0650163) =Organic Chemical; Pharmacologic Substance ;
27. ZBTB17
[This gene plays a role in transcriptional activation in response to cytoskeletal changes and inhibits cellular proliferation. ( NCI )] (UMLS (NCI) C1421641) ZBTB17 Gene;
Zinc Finger and BTB Domain Containing 17 Gene =Gene or Genome
77. Zoloft
(UMLS (NCI) C0284660) =Organic Chemical; Pharmacologic Substance ;
28. ZD 1839
(UMLS (NCI) C0879396) ZD1839 =Organic Chemical; Pharmacologic Substance ;
(UMLS (NCI) C0078839) =Organic Chemical; Pharmacologic Substance =pyridine;
29. ZD-1033
(UMLS (NCI) C0290882) =Organic Chemical; Pharmacologic Substance ;
79. Zolpidem Tartrate
[The tartrate salt form of zolpidem, an imidazopyridine derivative with sedative-hypnotic property. Zolpidem, a non-benzodiazepine compound, selectively binds to the omega-1 subclass of the gamma-aminobutyric acid (GABA) type A receptor, a chloride ionophore complex in the brain. This leads to the opening of chloride channels causing hyperpolarization and inhibition of neuronal firing, and mimicking synaptic actions of GABA. ( NCI )] (UMLS (NCI) C0724725) ZOLPIDEM TARTRATE PREPARATION =Organic Chemical; Pharmacologic Substance ;
30. ZD0473
[A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called platinum analogs. ( NCI )] (UMLS (NCI) C0671137) =Organic Chemical; Pharmacologic Substance
80. Zomax
(UMLS (NCI) C0149476) =Organic Chemical; Pharmacologic Substance
31. ZD1694
(UMLS (NCI) C0950790) =Organic Chemical; Pharmacologic Substance
(UMLS (NCI) C0078840) =Organic Chemical; Pharmacologic Substance
32. ZD2767
[A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy (ADEPT). (NCI) ( NCI )] (UMLS (NCI) C0385704) =Organic Chemical; Pharmacologic Substance ;
82. Zomepirac Sodium
(UMLS (NCI) C0149477) =Organic Chemical; Pharmacologic Substance
33. ZD4054
[An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. ZD4054 binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation. (NCI05) ( NCI )] (UMLS (NCI) C1328193) =Organic Chemical; Pharmacologic Substance ;
83. Zometapine
(UMLS (NCI) C0078842) =Organic Chemical; Pharmacologic Substance
34. ZD6126
[A water-soluble phosphate prodrug of N-acetylcolchinol with potential antineoplastic activity. ZD-6126 binds to and destabilizes the tubulin cytoskeleton of endothelial cells, thereby inhibiting angiogenesis which may result in tumor necrosis. (NCI04) ( NCI )] (UMLS (NCI) C1122629) ZD-6126 =Organic Chemical; Pharmacologic Substance ;
84. zona drilling
[ ] (UMLS (CSP) C0455168) =Therapeutic or Preventive Procedure
35. ZDX
(UMLS (NCI) C0149473) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
85. zona pellucida
[A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION. ( MSH )] (UMLS (CSP) C0043519) =Cell Component
36. zebra finch
[ ] (UMLS (CSP) C0326833) =Bird
86. zona pellucida glycoprotein
[extracellular matrix glycoprotein of the zona pellucida; ZP3 regulates initiation of sperm acrosomal exocytosis during mammalian fertilization. ( CSP )] (UMLS (CSP) C0597698) =Amino Acid, Peptide, or Protein; Biologically Active Substance =glycoprotein;
Extracellular Matrix Protein
37. Zelandopam
(UMLS (NCI) C1258361) =Organic Chemical; ;
87. zonal electrophoresis
[ ] (UMLS (CSP) C0597699) =Laboratory Procedure ;
38. Zemplar
(UMLS (NCI) C0724464) =Organic Chemical; Pharmacologic Substance
88. Zoniporide
(UMLS (NCI) C0971524) =Organic Chemical; Pharmacologic Substance ;
39. Zemuron
(UMLS (NCI) C0591463) =Organic Chemical; Pharmacologic Substance ;
89. Zoogloea
[A genus of RHODOCYCLACEAE occurring as rod-shaped cells embedded in a gelatinous matrix. It includes Z. filipendula. ( MSH )] (UMLS (CSP) C0043524) =Bacterium
40. Zen Buddhism
(UMLS (HL7) C0871624) =Idea or Concept ;
=Religious Affiliation;
90. Zoology
[The branch of biology dealing with the study of animals. ( NCI )] (UMLS (NCI) C0043526) =Biomedical Occupation or Discipline
41. Zeniplatin
[A third-generation, water-soluble platinum compound. (NCI) ( NCI )] (UMLS (NCI) C0055849) =Organic Chemical; Pharmacologic Substance ;
91. Zoonotic Infection
(UMLS (NCI) C0854537) =Disease or Syndrome
42. Zeolite
[Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed) ( MSH )] (UMLS (NCI) C0078755) =Inorganic Chemical
(UMLS (ICD9CM) C0152186) =Mental or Behavioral Dysfunction
43. zepto
[10*21 ( HL7V3.0 )] (UMLS (HL7) C1553040) =Quantitative Concept =UnitOfMeasurePrefixInsens;
93. zooplankton
[Minute free-floating animal organisms which live in practically all natural waters. ( MSH )] (UMLS (CSP) C0043530) =Invertebrate
44. zerit
[ ] (UMLS (CSP) C0701312) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
94. zoosemiotics
[ ] (UMLS (CSP) C0597858) =Social Behavior ;
45. Zestril
(UMLS (NCI) C0678140) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
95. Zoroastrianism
(UMLS (HL7) C0337701) =Idea or Concept ;
=Religious Affiliation;
46. zeta potential
[The magnitude of the electrical potential as generated by ion accumulation at the particulate surface. This surface consists of two layers, the Stern layer and the diffuse layer, which comprise an electrical double-layer. The measurement of the electrical potential provides important information regarding the dispersion mechanism, the degree of particle dispersion and the electrostatic potential of the sample. ( NCI )] (UMLS (CSP) C0597697) =Phenomenon or Process ;
96. Zosuquidar Trihydrochloride
[A substance that is being studied for its ability to reverse resistance to chemotherapy. Also called LY335979. ( NCI )] (UMLS (NCI) C0528372) =Organic Chemical; Pharmacologic Substance
(UMLS (NCI) C0078761) =Organic Chemical; Pharmacologic Substance ;
97. zovirax
[ ] (UMLS (CSP) C0592290) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
48. zetta
[10*-21 ( HL7V3.0 )] (UMLS (HL7) C1553023) =Quantitative Concept =UnitOfMeasurePrefixSens;
98. zoxazolamine
[A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. ( MSH )] (UMLS (CSP) C0043534) =Organic Chemical; Pharmacologic Substance ;
49. Zevalin
(UMLS (NCI) C0919274) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
99. ZP1
[ ] (UMLS (CSP) C0599959) =Amino Acid, Peptide, or Protein; Biologically Active Substance
50. ZFP36L2
[This gene plays a role in transcription and is postulated to regulate cellular responses to growth factors. ( NCI )] (UMLS (NCI) C1412825) ZFP36L2 Gene;
Zinc Finger Protein 36, C3H Type-Like 2 Gene =Gene or Genome
100. ZP2
[ ] (UMLS (CSP) C0599960) =Amino Acid, Peptide, or Protein; Enzyme

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