- 1101. 2-Chloro-4-Phenylphenol
- (UMLS (NCI) C0045999) =Organic Chemical; Pharmacologic Substance ;
| - 1151. 2-Propanone
- [colorless liquid used as a solvent and an antiseptic; one of the ketone bodies produced during ketoacidosis. ( CSP )] (UMLS (NCI) C0001002) =Organic Chemical; Pharmacologic Substance ;
|
- 1102. 2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nucleoside analogs. ( NCI )] (UMLS (NCI) C0092777) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 1152. 2-Propenamide
- [colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile; primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries. ( CSP )] (UMLS (NCI) C0050587) =Organic Chemical; Hazardous or Poisonous Substance ;
=amide;
=polyacrylamide;
|
- 1103. 2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea
- [An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0045644) =Organic Chemical; Pharmacologic Substance ;
| - 1153. 2-Propenenitrile
- [AK-rih-low-NYE-tril A substance used to make plastics, rubber, and textiles. Exposure to acrylonitrile may increase the risk of developing certain cancers (such as lung, brain, or prostate cancer). ( NCI )] (UMLS (NCI) C0001223) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 1104. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid
- [A synthetic, triterpenoid compound with anticancer and anti-inflammatory activities. CDDO blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. ( NCI )] (UMLS (NCI) C0762434) 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;
CDDO;
=Organic Chemical; Pharmacologic Substance | - 1154. 2-Propylpentanoic Acid
- [A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. ( NCI )] (UMLS (NCI) C0042291) =Lipid; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
Pentanoic Acids;
2-Propylpentanoic Acid;
=2-Propylpentanoic Acid;
2 propylvalerate;
DIVALPROEX SODIUM;
VALPROIC ACID 250 MG;
VALPROIC ACID 250 MG/5ML |
- 1105. 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
- [2-deoxy-2-(3-methyl-3-nitrosoureido) -D-glucopyranose; USP antineoplastic antibiotic; at high doses it destroys pancreatic beta cells and can be used to create experimental animal models of diabetes mellitus. ( CSP )] (UMLS (NCI) C0038432) =Carbohydrate; Antibiotic ;
=[AM300] AMINOGLYCOSIDES;
antineoplastic antibiotics;
nitrosourea;
=STREPTOZOCIN 1 GM/VIL;
| - 1155. 2-Propylpentanoic Acid Sodium Salt
- [The sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproate sodium may also affect potassium channels, thereby creating a direct membrane-stabilizing effect. ( NCI )] (UMLS (NCI) C0037567) =Lipid; Pharmacologic Substance ;
=2 propylvalerate;
=Sodium Valproate 100 MG/ML |
- 1106. 2-Deoxyphenobarbital
- [An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties. ( NCI )] (UMLS (NCI) C0033148) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione =PRIMIDONE 250 MG;
PRIMIDONE 50 MG;
PRIMIDONE 250 MG/5ML | - 1156. 2-Ring Heterocyclic Compound
- [A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic. ( NCI )] (UMLS (NCI) C0019400) =Organic Chemical =Heterocyclic Compound;
=benzazepine;
benzimidazole;
benzofuran;
benzopyran;
benzothiadiazine;
Benzoxazoles;
Indazoles;
Indole;
2 benzazine;
Naphthyridines;
pteridine;
purine;
quinazoline;
1 benzazine;
quinolizine;
Quinoxalines;
Bicyclo Compounds, Heterocyclic |
- 1107. 2-Diethylaminoethyl 4-amino-2-chlorobenzoate Hydrochloride
- [A synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma. ( NCI )] (UMLS (NCI) C0132182) =Organic Chemical; Pharmacologic Substance ;
=chloroprocaine;
=CHLOROPROCAINE HYDROCHLORIDE 2 %;
CHLOROPROCAINE HYDROCHLORIDE 1 %;
CHLOROPROCAINE HYDROCHLORIDE 3 %;
| - 1157. 2-Thiophenecarboxylic Acid, 4-Methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, Methyl Ester, Monohydrochloride
- [The hydrochloride salt form of articaine, an amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine. ( NCI )] (UMLS (NCI) C0007300) =Organic Chemical; Pharmacologic Substance ;
|
- 1108. 2-Ethyl-4-pyridinecarbothioamide
- [A nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. ( NCI )] (UMLS (NCI) C0015021) =Organic Chemical; Pharmacologic Substance ;
=Isonicotinic Acids;
[AM500] ANTITUBERCULARS =ETHIONAMIDE 250 MG | - 1158. 2-Thiourea
- [(NH2)2C=S; precursor and metabolite of 2-thiouracil, used for similar purposes. ( CSP )] (UMLS (NCI) C0039958) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =sulfur compound;
|
- 1109. 2-F-ara-AMP
- [The phosphate salt of fludarabine, a synthetic purine nucleoside antimetabolite with antineoplastic activity. Preferentially transported into malignant cells and metabolized to its active form 2-fluoro-ara-ATP by deoxycytidine kinase, fludarabine inhibits alpha DNA polymerase and RNA reductase and competes with deoxyadenosine triphosphate, resulting in inhibition of DNA primase, inhibition of DNA synthesis, and cell death. (NCI04) ( NCI )] (UMLS (NCI) C0060483) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =2-Fluoro-9-beta-arabinofuranosyladenine;
=FLUDARABINE PHOSPHATE 50 MG;
| - 1159. 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid
- [A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04) ( NCI )] (UMLS (NCI) C0012091) =Organic Chemical; Pharmacologic Substance =phenylacetate;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC;
=2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt;
2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt;
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt;
|
- 1110. 2-Fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene
- (UMLS (NCI) C0767920) =Organic Chemical; Pharmacologic Substance ;
| - 1160. 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt
- [The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. ( NCI )] (UMLS (NCI) C0700583) =Organic Chemical; Pharmacologic Substance =2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid;
=2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt;
DICLOFENAC SODIUM 0.1 %;
DICLOFENAC SODIUM 50 MG;
DICLOFENAC SODIUM 75 MG;
DICLOFENAC SODIUM 100 MG;
DICLOFENAC SODIUM 25 MG;
DICLOFENAC SODIUM 3 % |
- 1111. 2-Fluoro-9-beta-arabinofuranosyladenine
- [nucleoside analog used alone or in combination with other agents to treat various cancers, especially leukemia. ( CSP )] (UMLS (NCI) C0059985) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate;
adenine nucleoside;
nucleoside analog;
=2-F-ara-AMP;
| - 1161. 2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium Chloride
- [A synthetic quaternary ammonium base derivative, parasympathomimetic Bethanechol is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Generally used to increase smooth muscle tone, Bethanechol is used to treat reflux esophagitis and to initiate urination after surgery, in urinary infections, or for enlarged prostate. It may cause hypotension, cardiac rate changes, and bronchial spasms. (NCI04) ( NCI )] (UMLS (NCI) C0106169) =Organic Chemical; Pharmacologic Substance =bethanechol;
=BETHANECHOL CHLORIDE 25 MG;
BETHANECHOL CHLORIDE 10 MG;
BETHANECHOL CHLORIDE 50 MG;
BETHANECHOL CHLORIDE 5 MG;
|
- 1112. 2-Fluoro-alpha-methyl-4-diphenylacetic Acid Sodium Salt
- [The sodium salt form of flurbiprofen, a propionic acid derivative and a member of the phenylalkanoic acid group of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. ( NCI )] (UMLS (NCI) C0304658) =Organic Chemical; Pharmacologic Substance ;
=2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid;
[OP900] OPHTHALMICS, OTHER =FLURBIPROFEN SODIUM 0.03 %;
| - 1162. 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic Acid
- (UMLS (NCI) C0298617) =Organic Chemical; Pharmacologic Substance
|
- 1113. 2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid
- [A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. ( NCI )] (UMLS (NCI) C0016377) =Organic Chemical; Pharmacologic Substance ;
=Propionic Acids;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =2-Fluoro-alpha-methyl-4-diphenylacetic Acid Sodium Salt;
FLURBIPROFEN 100 MG;
FLURBIPROFEN 50 MG;
| - 1163. 2-[3-(Dimethyl-amino)propyl]-8,8-diethyl-2-aza-8-germaspiro[4,5]decane
- [A synthetic organometallic compound containing the element germanium with possible antineoplastic activity. Spirogermanium exhibits significant toxicity, particularly neurotoxicity. (NCI04) ( NCI )] (UMLS (NCI) C0075018) =Organic Chemical; Pharmacologic Substance ;
|
- 1114. 2-Hydroxy-1,2,3-propanetricarboxylic Acid
- [A tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood. ( NCI )] (UMLS (NCI) C0055819) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =[TN410] CITRATES;
2-Hydroxy-1,2,3-propanetricarboxylic Acid;
[PH000] PHARMACEUTICAL AIDS / REAGENTS;
=Citrate of Magnesia;
CITRATE;
CITRIC ACID More… | - 1164. 2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine
- (UMLS (NCI) C0067934) =Organic Chemical; Biologically Active Substance
|
- 1115. 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Calcium Salt (2:3)
- [The citrate salt of calcium. An element necessary for normal nerve, muscle, and cardiac function, calcium as the citrate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. (NCI04) ( NCI )] (UMLS (NCI) C0108101) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =[TN402] CALCIUM;
[TN410] CITRATES;
CITRATE;
TO BE DELETED INGREDIENT PREPARATIONS =CALCIUM (AS CITRATE) 200 MG;
CALCIUM (AS CITRATE) 500 MG;
LONALAC POWDER,ORAL;
CALCIUM CITRATE 1040 MG;
CALCIUM CITRATE 315 MG;
CALCIUM CITRATE 950 MG;
| - 1165. 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide
- [An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis. ( NCI )] (UMLS (NCI) C0077375) =Organic Chemical; Pharmacologic Substance ;
|
- 1116. 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Potassium Salt
- [The potassium salt form of citrate with alkalinizing property. Following absorption, potassium citrate causes increased plasma bicarbonate concentration, thereby raising blood and urinary pH. A simultaneous decrease in calcium ion activity occurs as a result of increasing calcium complex formation with dissociated anions. Levels of urinary citrate are increased due to modification of the renal handling of citrate. By promoting excretion of free bicarbonate ion and by increasing urinary pH in addition to an increased ionization of uric acid to more soluble urate ions, this agent exerts the alkalizing and anti-urolithic effect. ( More…
| - 1166. 2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
- [The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0163054) =Organophosphorus Compound; Pharmacologic Substance ;
|
- 1117. 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
- (UMLS (NCI) C0122812) =Organic Chemical; Pharmacologic Substance
| - 1167. 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline
- [nonselective alpha-adrenergic antagonist. ( CSP )] (UMLS (NCI) C0031448) =Organic Chemical; Pharmacologic Substance ;
=imidazole;
sympatholytic agent;
adrenergic antagonist;
=2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Monomethanesulfonate |
- 1118. 2-Hydroxy-4-methoxybenzophenone
- [A benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage. ( NCI )] (UMLS (NCI) C0069803) =Organic Chemical; Pharmacologic Substance ;
=Benzophenones;
[DE300] SUN PROTECTANTS/SCREENS, TOPICAL =LANOLIN/MINERAL OIL/OXYBENZONE OIL,TOP;
OCTYL METHOXYCINNAMATE/OCTYL SALICYLATE/OXYBENZONE SPF-15 LOTION;
OXYBENZONE/PABA (PRE-SUN 46) LOTION;
OXYBENZONE/PADIMATE O LOTION;
OXYBENZONE/PETROLATUM OINT,TOP;
SUNSCREEN-15 PABA-FREE COMBINATION GEL;
SUNSCREEN-30 PABA-FREE COMBINATION LOTION;
OXYBENZONE 6 %;
OXYBENZONE 2 %;
OXYBENZONE 2.3 %;
OXYBENZONE 5 %;
OXYBENZONE 3 %;
ALPHA KERI BATH OIL;
BATH OIL;
AMINOBENZOIC ACID/BENZOPHENONE LOTION (ML);
THERI BATH OIL;
NUTRADERM BATH OIL | - 1168. 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Monomethanesulfonate
- [The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. ( NCI )] (UMLS (NCI) C0733398) PHENTOLAMINE MESYLATE;
PHENTOLAMINE MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline;
=PHENTOLAMINE MESYLATE 5 |
- 1119. 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid
- [A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase and prostaglandin production and is used in the management of inflammatory bowel diseases. (NCI04) ( NCI )] (UMLS (NCI) C0036078) =Organic Chemical; Pharmacologic Substance =sulfonamide;
[GA900] GASTRIC MEDICATIONS, OTHER =SULFASALAZINE 500 MG;
SULFASALAZINE 250 MG/5ML;
| - 1169. 2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine
- [USP lists as a gonad stimulating principle; is a fertility inhibitor in male and female rats, but is a fertility stimulant in women used to induce multiple births. ( CSP )] (UMLS (NCI) C0009008) =Organic Chemical; Pharmacologic Substance ;
=fertility promoting drug;
[HS400] GONADOTROPINS;
[HS800] PROGESTINS;
stilbene =2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine Citrate;
|
- 1120. 2-Hydroxyamino-2-ethanal
- [A urea analogue with bacterial urease inhibiting activity. Acetohydroxamic acid is used as adjunctive therapy in the treatment of urinary tract infections caused by urease-producing bacteria. In addition, this drug is used in the prophylaxis and treatment of struvite renal calculi, whose formation is favored by urease-producing bacteria, by dissolving renal stones as well as preventing the formation of new crystals. (NCI05) ( NCI )] (UMLS (NCI) C0050451) =Organic Chemical; Pharmacologic Substance =Hydroxamic Acids;
Unclassified Ingredient Preparations =ACETOHYDROXAMIC ACID 250 MG;
| - 1170. 2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine Citrate
- [The citrate salt form of clomiphene, a triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer. Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues. This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04) ( NCI )] (UMLS (NCI) C0546859) =Organic Chemical; Pharmacologic Substance =2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine;
=CLOMIPHENE CITRATE 50 MG;
|
- 1121. 2-Hydroxybenzoic Acid
- [A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed) ( MSH )] (UMLS (NCI) C0036079) =Organic Chemical; Pharmacologic Substance =2-Hydroxybenzoic Acid;
Salicylic Acids;
[DE752] ANTIACNE AGENTS, TOPICAL;
[DE500] KERATOLYTICS/CAUSTICS, TOPICAL =Salicylates;
PYRITHIONE ZINC 1% SHAMPOO;
BI SUBSALICYLATE 260MG/MG AL SILICATE/SAL AC/NA SALICYLATE/30ML;
BI SUBSALICYLATE 459MG/MG AL SILICATE/SAL AC/NA SALICYLATE/30ML;
COAL TAR 5%/LASSAR PASTE,TOP;
Coal Tar / Salicylic Acid Topical Cream;
DRYTEX LOTION;
EUCALYPTUS OIL/ME SALICYLATE/PEPPERMINT OIL/SALICYLIC AC LIQ,TOP;
GORDOMATIC PWDR,TOP;
SALICYLIC ACID GEL,TOP;
SALICYLIC ACID POWDER (GM);
NAIL FUNGAL SOLN,TOP;
COAL TAR/SALICYLIC ACID LOTION;
CARMEX OINT,TOP;
SALICYLIC ACID 0.1 %;
SALICYLIC ACID 4 GM;
SALICYLIC ACID 13.57 %;
SALICYLIC ACID 40 %;
SALICYLIC ACID 0.5 %;
SALICYLIC ACID 1 %;
SALICYLIC ACID 5 %;
SALICYLIC ACID 2.5 %;
SALICYLIC ACID 12.2 %;
SALICYLIC ACID 2.35 %;
SALICYLIC ACID 26 %;
SALICYLIC ACID 6 %;
SALICYLIC ACID 50 %;
SALICYLIC ACID 12 %;
SALICYLIC ACID 1.8 %;
SALICYLIC ACID 4 %;
SALICYLIC ACID 10 %;
SALICYLIC ACID 16.7 %;
SALICYLIC ACID 30 %;
SALICYLIC ACID 2.25 %;
SALICYLIC ACID 24 %;
SALICYLIC ACID 14.2 %;
SALICYLIC ACID 1.5 %;
SALICYLIC ACID 2 %;
SALICYLIC ACID 3 %;
SALICYLIC ACID 17 %;
SALICYLIC ACID 25 %;
SALICYLIC ACID 60 %;
2-Hydroxybenzoic Acid | - 1171. 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt
- [An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04) ( NCI )] (UMLS (NCI) C0068006) =Organophosphorus Compound; Pharmacologic Substance
|
- 1122. 2-Hydroxypropanoic Acid Sodium Salt
- [A sodium salt of racemic or inactive lactic acid with alkalinizing and electrolyte replenishing property. Upon metabolism, sodium lactate is converted to bicarbonate, thereby increasing plasma bicarbonate, which facilitates removal of hydrogen ion and lactate from blood stream and leads to raised blood pH. ( NCI )] (UMLS (NCI) C0142874) =Organic Chemical; Pharmacologic Substance ;
=lactate;
[TN102] IV SOLUTIONS WITH ELECTROLYTES;
[TN499] ELECTROLYTES/MINERALS, OTHER;
=MASSENGILL DISPOSABLE DOUCHE;
Carboxymethylcellulose 5 MG/ML Ophthalmic Solution;
MASSENGILL DISPOSABLE DOUCHE BELLE-MAI,VAG;
SODIUM LACTATE 5 MEQ/ML;
MASSENGILL DOUCHE,VAG;
Sodium Lactate 3.1 MG/ML;
Sodium Lactate 2.6 MG/ML;
Sodium Lactate 2.2 MG/ML;
SODIUM LACTATE 0.062 GM/100ML;
SODIUM LACTATE 0.392 GM/100ML;
SODIUM LACTATE 138 MG/100ML;
SODIUM LACTATE 155 MG/100ML;
SODIUM LACTATE 224 MG/100ML;
SODIUM LACTATE 246 MG/100ML;
SODIUM LACTATE 25 ML;
SODIUM LACTATE 280 MG/100ML;
SODIUM LACTATE 390 MG/100ML;
SODIUM LACTATE 392 MG/100ML;
SODIUM LACTATE 448 MG/100ML;
SODIUM LACTATE 50 ML;
SODIUM LACTATE 500 MG/100ML;
SODIUM LACTATE 62 MG/100ML;
SODIUM LACTATE 670 MG/100ML;
SODIUM LACTATE 672 MG/100ML;
SODIUM LACTATE 672.4 MG/100ML;
SODIUM LACTATE 89.6 MG/100ML;
SODIUM LACTATE 0.056 %;
SODIUM LACTATE 5 %;
SODIUM LACTATE 1;
PODOFILOX 0.5 %WW TOPICAL SOLUTION;
| - 1172. 2.7.1.112
- [Related to B cell activation, PTK72 is a tyrosine kinase that becomes tyrosine phosphorylated and activated soon after anti-Ig stimulation of B cells. It is found associated with the mIg receptor complex. Unlike the membrane-bound Src-family tyrosine kinases, PTK72 is primarily present as a soluble cytosolic protein. It is probably the product of the syk gene and is highly related to the ZAP-70 protein associated with T cell activation. ( NCI )] (UMLS (NCI) C0134982) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 1123. 2-Imino-4-keto-5-phenyltetrahydrooxazole
- [An oxazolidine compound with central nervous system (CNS) stimulant property. Although pemoline has pharmacological activity similar to other CNS stimulants, the exact mechanism and site of action are unknown. This agent has minimal sympathomimetic properties, but animal studies indicate it may work through dopaminergic mechanisms. Pemoline has been withdrawn from the U.S. market because of the agent's association with life threatening hepatic failure. ( NCI )] (UMLS (NCI) C0030800) =Organic Chemical; Pharmacologic Substance =oxazole;
[CN809] CNS STIMULANTS, OTHER =PEMOLINE 37.5 MG;
PEMOLINE 75 MG;
PEMOLINE 18.75 MG;
| - 1173. 20
- [Mandibular left second premolar ( HL7V3.0 )] (UMLS (HL7) C0227059) tooth 20 =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 1124. 2-Isopropylaminopyrimidine
- (UMLS (NCI) C0063890) =Organic Chemical; Pharmacologic Substance ;
| - 1174. 20 minutes post challenge
- (UMLS (HL7) C1547069) =Temporal Concept =Time delay post challenge;
|
- 1125. 2-Mercaptoethanesulfonate, Sodium Salt
- [A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide. ( NCI )] (UMLS (NCI) C0000294) =Organic Chemical; Pharmacologic Substance ;
| - 1175. 20-29% BDY BRN/10-19% 3D
- [ ] (UMLS (ICD9CM) C0161334) =Injury or Poisoning
|
- 1126. 2-Mercaptopyridine 1-oxide Zinc Salt
- [An organometallic compound and a derivative of the naturally occurring antibiotic aspergillic acid with antimicrobial, antifungal and anti-seborrheic effects. Although the mechanism of action has not been fully elucidated, pyrithione zinc maybe entering the cell in its chelate from, dissociating in the cytoplasm and exerting its anti-proliferative effect possibly through interaction with DNA. Alternatively, pyrithione might act by chelating metal cofactors of enzymes through its sulfhydryl group. Pyrithione has also been shown to interfere with thymidine uptake and may act as an antimetabolite for nicotinic acid or vitamin B6. Finally, pyrithione may act as a general transport inhibitor through weak-acid-induced cytosolic acidification and hence partial dissipation of the transmembrane proton motive force (PMF) on which the transport of many organic and inorganic solutes is reliant. ( NCI )] (UMLS (NCI) C0078792) =Organic Chemical; Pharmacologic Substance ;
=Organometallic Compound;
pyridine;
Pyrithione;
Unclassified Ingredient Preparations =PYRITHIONE ZINC 2 %;
PYRITHIONE ZINC 1 %;
PYRITHIONE ZINC 2 %;
PYRITHIONE ZINC 1 %;
| - 1176. 20-29% BDY BRN/20-29% 3D
- [ ] (UMLS (ICD9CM) C0161335) =Injury or Poisoning
|
- 1127. 2-Methoxy-5-Methylaniline
- [A white, crystalline aromatic amine that is soluble in organic solvents and emits toxic fumes of nitrogen oxides when heated to decomposition. p-Cresidine is exclusively used as a chemical intermediate in the manufacture of dyes. p-Cresidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0056481) =Organic Chemical; Pharmacologic Substance ;
| - 1177. 20-29% BDY BRN/3 DEG NOS
- [ ] (UMLS (ICD9CM) C0161333) =Injury or Poisoning
|
- 1128. 2-Methyl-1,3-butadiene
- [An unsaturated pentahydrocarbon, Isoprene is found in certain plants or obtained by distillation of caoutchouc or gutta-percha. In plants, it is elementary in the formation of isoprenoids, fat-soluble vitamins, carotenoids and related pigments. Isoprenes contribute to flavors and fragrances of essential oils and other plant-derived substances. (NCI04) ( NCI )] (UMLS (NCI) C0064044) =Organic Chemical
| - 1178. 20a
- [Mandibular left second premolar abutment ( HL7V3.0 )] (UMLS (HL7) C1553658) =Medical Device =Artificial dentition;
|
- 1129. 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- [A sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI) ( NCI )] (UMLS (NCI) C0025627) =Organic Chemical; Pharmacologic Substance ;
| - 1179. 20i
- [Mandibular left second premolar implant ( HL7V3.0 )] (UMLS (HL7) C1552190) =Medical Device =Artificial dentition;
|
- 1130. 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- [A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension. ( NCI )] (UMLS (NCI) C0025854) =Organic Chemical; Pharmacologic Substance ;
=[CV701] THIAZIDES/RELATED DIURETICS;
quinazoline;
sulfonamide;
=METOLAZONE 0.5 MG;
METOLAZONE 10 MG;
METOLAZONE 2.5 MG;
METOLAZONE 5 MG;
| - 1180. 20p
- [Mandibular left second premolar prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553595) =Medical Device =Artificial dentition;
|
- 1131. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
- [A synthetic derivative of thienobenzodiazepine with antipsychotic properties. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 antagonism. ( NCI )] (UMLS (NCI) C0171023) =Organic Chemical; Pharmacologic Substance ;
=Pirenzepine;
[CN709] ANTIPSYCHOTICS, OTHER =olanzapine 10 MG Disintegrating Tablet;
OLANZAPINE 10 MG;
OLANZAPINE 2.5 MG;
OLANZAPINE 7.5 MG;
OLANZAPINE 5 MG;
OLANZAPINE 15 MG;
OLANZAPINE 20 MG | - 1181. 20pd
- [Mandibular left second premolar distal prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553594) =Medical Device =Artificial dentition;
|
- 1132. 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- [An anticancer drug that belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0016384) =Organic Chemical; Pharmacologic Substance ;
=Anilides;
[AN000] ANTINEOPLASTICS =FLUTAMIDE 125 MG;
| - 1182. 20pm
- [Mandibular left second premolar mesial prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553596) =Medical Device =Artificial dentition;
|
- 1133. 2-methylacyl-CoA Racemase
- [Human alpha-methylacyl-CoA racemase protein (382 aa, ~42.4 kDa) is encoded by the AMCAR gene (AMACR). This protein is an enzyme that is involved in the beta-oxidation of branched-chain fatty acids. Overexpression of this protein has been found in several carcinomas, thus it is considered an important biomarker in the pathogenesis of breast, prostate, and colon cancers. ( NCI )] (UMLS (NCI) C0666209) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 1183. 20s
- [Supernumerary mandibular left second premolar ( HL7V3.0 )] (UMLS (HL7) C1552134) =Body Part, Organ, or Organ Component =SUPERNUMERARY TEETH;
|
- 1134. 2-Methylallyl Chloride
- [A synthetic, flammable, volatile, colorless to straw-colored liquid that is insoluble in water and soluble in chloroform, acetone, alcohol, ether and benzene. It is used primarily as a chemical intermediate in the production of carbofuran, a carbamate insecticide; used in the production of herbicides, plastics, pharmaceuticals, and other organic as well as an additive in textiles and perfumes. When heated to decomposition, it emits toxic fumes of hydrochloric acid and other chlorinated compounds. Contact exposure of this substance causes irritation of the eyes and skin. Inhalation can lead to irritation of the respiratory tract and depression of the central nervous system. Breathing at high levels of 3-chloro-2-methylpropene vapors may induce coughing, gasping, breathing difficulties and extreme respiratory distress, even coma. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047290) =Organic Chemical; Hazardous or Poisonous Substance
| - 1184. 20S Catalytic Proteasome
- [macromolecular structures present in the cytosol and nucleus in cells; have multiple protease activities. ( CSP )] (UMLS (NCI) C0208355) =Amino Acid, Peptide, or Protein; Enzyme ;
=cell nucleus;
cytoplasm |
- 1135. 2-Naphthacenecarboxamide, 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, Monohydrochloride,(4S-(4alpha,4aalpha,5alpha,5aalpha,12aalpha))-
- [The hydrochloride salt form of methacycline, a tetracycline antibiotic with broad-spectrum antibacterial and antiprotozoal activity. Methacycline hydrochloride is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative bacteria. ( NCI )] (UMLS (NCI) C0770655) Methacycline Hydrochloride;
METHACYCLINE HYDROCHLORIDE PREPARATION;
Optimycin;
Rindex =Organic Chemical; Antibiotic =METHACYCLINE;
=METHACYCLINE HYDROCHLORIDE 300 MG;
METHACYCLINE HYDROCHLORIDE 150 MG | - 1185. 21
- [Mandibular left first premolar ( HL7V3.0 )] (UMLS (HL7) C0227060) tooth 21 =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 1136. 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochloride(4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-
- [A tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative organisms, spirochetes, rickettsial species, certain protozoa and Mycoplasma and Chlamydia organisms. ( NCI )] (UMLS (NCI) C0085855) =Organic Chemical; Antibiotic =chlortetracycline;
| - 1186. 21+ years old
- [A human who has reached reproductive age. ( NCI )] (UMLS (CSP) C0001675) =Age Group ;
|
- 1137. 2-Naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, ester with 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)-ethoxy)ethanol
- [The pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine pamoate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine pamoate crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05) ( NCI )] (UMLS (NCI) C0700539) =Organic Chemical; Pharmacologic Substance =HYDROXYZINE;
=HYDROXYZINE PAMOATE 100 MG;
HYDROXYZINE PAMOATE 50 MG;
HYDROXYZINE PAMOATE 25 MG/5ML;
HYDROXYZINE PAMOATE 25 MG;
| - 1187. 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
- [The acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate diffuses through the cell membrane and binds to nuclear glucocorticoid receptors. The receptor-ligand complex binds to promotor regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. ( NCI )] (UMLS (NCI) C0056391) =Steroid; Pharmacologic Substance; Hormone =17,21-Dihydroxypregn-4-ene-3,11,20-trione;
=CORTISONE ACETATE 25 MG;
CORTISONE ACETATE 50 MG/ML;
CORTISONE ACETATE 5 MG;
CORTISONE ACETATE 10 MG;
|
- 1138. 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
- [A nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis. (NCI) ( NCI )] (UMLS (NCI) C0053230) =Organic Chemical; Pharmacologic Substance ;
| - 1188. 21-34 years old
- [human having attained full growth or maturity; from age 21 through 34; also index with appropriate human and clinical research terms. ( CSP )] (UMLS (CSP) C0597696) =Age Group ;
=21+ years old;
|
- 1139. 2-Nitropropane
- [A synthetic, flammable, colorless liquid that is slightly soluble in water, and miscible with most aromatic hydrocarbons, ketones, esters, ethers and the lower carboxylic acids. It is used primarily both as a chemical intermediate and as a solvent for numerous commercial products. 2-Nitropropane is also used as a component of explosives and propellants, and in fuels for internal combustion engines. The primary routes of potential human exposure to 2-nitropropane are dermal contact, inhalation, and ingestion. Contact with this compound can cause irritation of the eyes and skin. Acute inhalation exposure to low levels of 2-nitropropane vapors can result in irritation of the respiratory tract. Breathing higher levels of this chemical may cause anorexia, nausea, vomiting and diarrhea. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0046453) =Organic Chemical; Hazardous or Poisonous Substance
| - 1189. 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
- [The propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activates gene expression of anti-inflammatory proteins mediated via corticosteroid receptor respond element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema and pruritus through its cutaneous effects on vascular dilation and permeability. ( NCI )] (UMLS (NCI) C0098735) =Steroid; Pharmacologic Substance ;
=CLOBETASOL;
Halobetasol =Halobetasol;
HALOBETASOL PROPIONATE 0.05 % |
- 1140. 2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-
- [A member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release. ( NCI )] (UMLS (NCI) C0528166) =Organic Chemical; Pharmacologic Substance ;
=[CN105] ANTIMIGRAINE AGENTS;
Oxazolidinones =ZOLMITRIPTAN 2.5 MG;
ZOLMITRIPTAN 5 MG;
| - 1190. 21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione Cyclic 16,17-Acetal with Acetone
- [A topical, synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Halcinonide exerts its effect by interacting with specific intracellular receptors, and the ligand-receptor complex subsequently modulates gene expressions via the typical glucocorticoid signalling pathway. This results in the synthesis of certain anti-inflammatory proteins as well as in synthesis inhibition of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05) ( NCI )] (UMLS (NCI) C0018513) =Steroid; Pharmacologic Substance =Pregnenediones;
[DE200] ANTI-INFLAMMATORY, TOPICAL =HALCINONIDE 0.025 %;
HALCINONIDE 0.1 %;
|
- 1141. 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-
- [An oxazolidinone with centrally-acting skeletal muscle relaxant properties. Although the exact mechanism through which metaxalone exerts its effect is largely unknown, it might be due to general central nervous system (CNS) depression. Metaxalone has no direct effect on the contractile mechanisms of striated muscle, the motor end plate, or the nerve fiber. ( NCI )] (UMLS (NCI) C0163055) =Organic Chemical; Pharmacologic Substance ;
=[MS200] SKELETAL MUSCLE RELAXANTS;
Oxazolidinones =METAXALONE 400 MG;
METAXALONE 800 MG;
| - 1191. 21-kDa TBP-Like Protein
- [Ubiquitously expressed (highest in testis and brain) human TBPL1 Gene (TBP Family), encodes 186-aa 21-kDa DNA-binding TBP-Like Protein 1, which serves the same function as TBP, substituting for TBP at some promoters not recognized by TFIID. TBPL1 binds TFIIA and TFIIB, does not bind the TATA box, may be important in expression of some developmentally regulated genes, and is essential for spermiogenesis. (NCI) ( NCI )] (UMLS (NCI) C1336592) STUD Protein;
TATA Box Binding Protein-Like Protein 1;
TATA Box Binding Protein-Related Factor 2;
TBP-Like Protein 1;
TBP-Related Factor 2;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 1142. 2-Oxetanone
- [A colorless, highly reactive, liquid, cyclic ether with a slightly sweet odor. Beta-propiolactone was used once mainly in the manufacture of acrylic acid and esters. It also was used as a sterilant for medical materials and procedures. However, it is no longer used for medical disinfection. Dermal exposure to beta-propiolactone causes the burning or blistering of the skin, and ingestion of this substance burns the mouth and stomach while exposure to its vapors causes severe irritation of the eyes, throat and respiratory tract. This substance is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0033472) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 1192. 21-Tungsto-9-antimonate
- [An anti-HIV agent. May also function as an antineoplastic agent ( NCI )] (UMLS (NCI) C0098687) =Pharmacologic Substance; Inorganic Chemical ;
|
- 1143. 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
- [2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine; cyclophosphamide analog with two alkylating groups, used as a DNA strand crosslinker and antineoplastic. ( CSP )] (UMLS (NCI) C0020823) =Organophosphorus Compound; Pharmacologic Substance ;
=Alkylating Activity;
[AN000] ANTINEOPLASTICS;
(-)-Cyclophosphamide;
phosphamide;
oxazine;
Antineoplastic Alkylating Agent =IFOSFAMIDE 1 GM/VIL;
IFOSFAMIDE 3 GM;
IFOSFAMIDE 1 GM;
| - 1193. 21a
- [Mandibular left first premolar abutment ( HL7V3.0 )] (UMLS (HL7) C1553659) =Medical Device =Artificial dentition;
|
- 1144. 2-Phenazinamine, 3,5-dihydro-N,5-bis(4-chlorophenyl)-3-((1-methylethyl)imino)-
- [A phenazine dye with anti-mycobacterial and anti-inflammatory activity. The exact mechanism through which clofazime exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria. ( NCI )] (UMLS (NCI) C0008996) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =phenazine;
[AM900] ANTI-INFECTIVES, OTHER =CLOFAZIMINE 50 MG;
| - 1194. 21i
- [Mandibular left first premolar implant ( HL7V3.0 )] (UMLS (HL7) C1552191) =Medical Device =Artificial dentition;
|
- 1145. 2-Phenyl-1,3-propanediol Dicarbamate
- [A propanediol compound with anticonvulsant and antiepileptic properties. Although the exact mechanism of action is unknown, Felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex, thereby blocking the effects of the excitatory amino acids, suppressing neuronal firing, and preventing seizure activity. Felbamate also has weak inhibitory effects on gamma-aminobutyric acid (GABA) receptor binding sites which may contribute to its inhibitory effect on neuronal excitatory. ( NCI )] (UMLS (NCI) C0060135) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
propanediol =felbamate 120 MG/ML;
FELBAMATE 600 MG;
FELBAMATE 400 MG;
| - 1195. 21p
- [Mandibular left first premolar prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553598) =Medical Device =Artificial dentition;
|
- 1146. 2-Phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate
- (UMLS (NCI) C0054434) =Organic Chemical; Pharmacologic Substance ;
| - 1196. 21pd
- [Mandibular left first premolar distal prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553597) =Medical Device =Artificial dentition;
|
- 1147. 2-Phenylethylhydrazine Hydrogen Sulphate
- [A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects. ( NCI )] (UMLS (NCI) C0031393) =Organic Chemical; Pharmacologic Substance ;
=PHENELZINE;
=PHENELZINE SULFATE 15 MG | - 1197. 21pm
- [Mandibular left first premolar mesial prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553599) =Medical Device =Artificial dentition;
|
- 1148. 2-Piperidineacetic Acid, Alpha-phenyl-, Methyl Ester, Hydrochloride, (alphaR,2R)-
- [A synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of attention deficit hyperactivity disorder. It may also be used in the treatment of fatigue and other nervous system effects seen with chemotherapy. ( NCI )] (UMLS (NCI) C1170743) DEXMETHYLPHENIDATE HYDROCHLORIDE;
d-threo-Methylphenidate Hydrochloride =Organic Chemical; Pharmacologic Substance | - 1198. 21s
- [Supernumerary mandibular left first premolar ( HL7V3.0 )] (UMLS (HL7) C1552135) =Body Part, Organ, or Organ Component =SUPERNUMERARY TEETH;
|
- 1149. 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate Hydrochloride
- [The hydrochloride salt form of flavoxate, a parasympatholytic agent with antispasmodic activity. Flavoxate hydrochloride competitively binds to muscarinic receptors, thereby preventing the actions of acetylcholine. This relaxes vascular smooth muscle, mainly of the urinary tract, and prevents smooth muscle contractions. ( NCI )] (UMLS (NCI) C0546865) =Organic Chemical; Pharmacologic Substance =FLAVOXATE;
=FLAVOXATE HYDROCHLORIDE 100 MG;
| - 1199. 22
- [Mandibular left canine ( HL7V3.0 )] (UMLS (HL7) C0227061) tooth 22 =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 1150. 2-Propanol-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy) Hydrochloride
- [The hydrochloride form of propranolol, a synthetic beta-adrenergic receptor blocker with antianginal, antiarrhythmic, antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby inhibiting beta-adrenergic reactions, such as vasodilation, and negative chronotropic and inotropic effects. ( NCI )] (UMLS (NCI) C0282321) =Organic Chemical; Pharmacologic Substance ;
=1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol;
=PROPRANOLOL HYDROCHLORIDE 60 MG;
PROPRANOLOL HYDROCHLORIDE 80 MG;
PROPRANOLOL HYDROCHLORIDE 120 MG;
PROPRANOLOL HYDROCHLORIDE 160 MG;
PROPRANOLOL HYDROCHLORIDE 80 MG/ML;
PROPRANOLOL HYDROCHLORIDE 1 MG/ML;
PROPRANOLOL HYDROCHLORIDE 20 MG/5ML;
PROPRANOLOL HYDROCHLORIDE 40 MG/5ML;
PROPRANOLOL HYDROCHLORIDE 10 MG;
PROPRANOLOL HYDROCHLORIDE 40 MG;
PROPRANOLOL HYDROCHLORIDE 20 MG;
PROPRANOLOL HYDROCHLORIDE 90 MG | - 1200. 22-Oxovincaleukoblastine
- [inhibits microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. ( CSP )] (UMLS (NCI) C0042679) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
vinca alkaloid =Leurocristine Sulfate |
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