- 1. TOLAZAMIDE
- [A sulfonylurea derivative and an antidiabetic agent with hypoglycemic property. Tolazamide binds to the ATP-dependent potassium channels on the plasma membrane of pancreatic beta-cells, which results in an inhibition of potassium efflux and membrane depolarization. Membrane depolarization stimulates calcium influx through voltage-gated calcium channels and subsequently induces the release of insulin from viable beta-cells thereby leading to a decrease in blood glucose levels. In addition, this agent potentiates the anti-diuretic effect of antidiuretic hormone (ADH). ( NCI )] (UMLS (NCI) C0040372) =Organic Chemical; Pharmacologic Substance ;
=sulfonylurea;
[HS502] HYPOGLYCEMIC AGENTS, ORAL =TOLAZAMIDE 100 MG;
TOLAZAMIDE 250 MG;
TOLAZAMIDE 500 MG;
| - 7. TOLMETIN
- [A synthetic non-steroidal anti-inflammatory agent with pyrrole structure, analgesic and antipyretic Tolmetin has a mode of action similar to indomethacin, but is less potent. Used in the treatment of rheumatoid arthritis, it inhibits prostaglandin synthase and decreases production of inflammatory prostaglandin E. (NCI04) ( NCI )] (UMLS (NCI) C0040377) =Organic Chemical; Pharmacologic Substance ;
=pyrrole;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =TOLMETIN SODIUM;
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- 2. TOLAZOLINE
- [A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. ( MSH )] (UMLS (NCI) C0040373) =Organic Chemical; Pharmacologic Substance ;
=imidazole;
[CV500] PERIPHERAL VASODILATORS =TOLAZOLINE HYDROCHLORIDE;
| - 8. Tolterodine
- [A benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine receptor binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract.. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects. ( NCI )] (UMLS (NCI) C0388753) =Organic Chemical; Pharmacologic Substance ;
=Benzhydryl Compounds;
Cresols;
parasympatholytic agent;
=Tolterodine Tartrate |
- 3. TOLBUTAMIDE
- [sulfonylurea compound used as a hypoglycemic in the treatment of noninsulin dependent diabetes mellitus. ( CSP )] (UMLS (NCI) C0040374) =Organic Chemical; Pharmacologic Substance ;
=sulfonylurea;
[HS502] HYPOGLYCEMIC AGENTS, ORAL =TOLBUTAMIDE SODIUM;
TOLBUTAMIDE 500 MG | - 9. Tolterodine Tartrate
- [The tartrate salt form of tolterodine, a benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine receptor binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract.. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects. ( NCI )] (UMLS (NCI) C0724710) TOLTERODINE TARTRATE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=Tolterodine;
=TOLTERODINE TARTRATE 1 MG;
TOLTERODINE TARTRATE 2 MG;
TOLTERODINE TARTRATE 4 MG |
- 4. Toll Interacting Protein Gene
- [This gene is involved in signal transduction and regulation of protein trafficking. ( NCI )] (UMLS (NCI) C1336655) TOLLIP;
TOLLIP Gene =Gene or Genome ;
| - 10. toluene
- [methylbenzene; organic solvent used in rubber and plastic cements, paint removers, etc; poisoning may result from ingestion or inhalation. ( CSP )] (UMLS (CSP) C0040383) =Organic Chemical =Benzene Derivatives;
cycloalkene;
Additive/Preservative;
=Toluidines;
Tosyl Compounds |
- 5. Toll-Interacting Protein
- [Encoded by human TOLLIP Gene, 274-aa 30-kDa oligomeric Toll-Interacting Protein, containing a CUE domain, is involved in IL-1 and Toll-like receptor signaling pathways. TOLLIP binds to TLR2 and TLR4/MD2 complex via its C-terminus. Complexed with Ser/Thr kinase IRAK in unstimulated cells, TOLLIP inhibits IRAK phosphorylation and kinase activity. Upon IL-1 signaling, TOLLIP interacts with the IL-1RacP TIR domain in the activated receptor complex (IL-1RI/IL-1RacP/MyD88), recruiting IRAK to the complex. MyD88 triggers IRAK1 autophosphorylation and IRAK1 dissociation. (NCI) ( NCI )] (UMLS (NCI) C0915585) TOLLIP;
TOLLIP Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 11. Toluene
- [Also known as Methylbenzene; Toluol; Phenylmethane. A preservative for 24 Hr Urine samples ( HL7V3.0 )] (UMLS (HL7) C1556063) =Intellectual Product =MaterialEntityAdditive;
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- 6. Toll-Like Receptor Family Gene
- [Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which respond to various microbial components and mediate pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine production and secretion, and inflammatory response. (NCI) ( NCI )] (UMLS (NCI) C1336763) =Gene or Genome ;
| - 12. toluylene
- [ ] (UMLS (CSP) C0599478) =Organic Chemical
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