[A sulfonylurea derivative and an antidiabetic agent with hypoglycemic property. Tolazamide binds to the ATP-dependent potassium channels on the plasma membrane of pancreatic beta-cells, which results in an inhibition of potassium efflux and membrane depolarization. Membrane depolarization stimulates calcium influx through voltage-gated calcium channels and subsequently induces the release of insulin from viable beta-cells thereby leading to a decrease in blood glucose levels. In addition, this agent potentiates the anti-diuretic effect of antidiuretic hormone (ADH). ( NCI )]
UMLS (NCI) C0040372 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: sulfonylurea
[HS502] HYPOGLYCEMIC AGENTS, ORAL
Relation/CHD: TOLAZAMIDE 100 MG
TOLAZAMIDE 250 MG
TOLAZAMIDE 500 MG