- 1. (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide
- [A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04) ( NCI )] (UMLS (NCI) C0135981) =Amino Acid, Peptide, or Protein; Antibiotic ;
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