- 1. (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid
- [An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor. ( NCI )] (UMLS (NCI) C0338344) =Organic Chemical; Pharmacologic Substance
| - 24. SR-47436
- [ ] (UMLS (CSP) C0701003) =Organic Chemical; Pharmacologic Substance ;
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- 2. (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid
- [semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. ( CSP )] (UMLS (NCI) C0002680) =Organic Chemical; Antibiotic ;
| - 25. SR-720-22
- (UMLS (NCI) C0701384) =Organic Chemical; Pharmacologic Substance
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- 3. (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione
- [A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. (NCI04) ( NCI )] (UMLS (NCI) C0962559) 12,13-Deoxyepothilone B;
Desoxyepothilone B;
Epothilone D;
=Organic Chemical; Pharmacologic Substance ;
| - 26. SR47436
- [ ] (UMLS (CSP) C0872274) =Organic Chemical; Pharmacologic Substance
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- 4. (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0076959) =Organic Chemical; Pharmacologic Substance ;
| - 27. SRC Family Gene
- [Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20. ( MSH )] (UMLS (NCI) C0038085) =Gene or Genome ;
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- 5. 18S Ribosomal RNA
- [The second largest of the three RNA components of the mammalian ribosome. ( NCI )] (UMLS (NCI) C0035703) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance
| - 28. SRC Family Oncogene
- [Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which encode diverse SRC Family Tyrosine Kinases, closely related intracellular non-receptor protein-tyrosine kinases with amino acid sequence similarity to SRC and to Rous sarcoma virus oncogene protein PP60(V-SRC). SRC tyrosine kinases interact with diverse cell-surface receptors and participate in intracellular signal transduction pathways in a variety of hematopoietic cells. Oncogenic SRC kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes. SRC family oncogenes disrupt normal cell function. ( NCI )] (UMLS (NCI) C0919476) =Gene or Genome ;
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- 6. 28S Ribosomal RNA
- [The largest of the three RNA components of the mammalian ribosome. ( NCI )] (UMLS (NCI) C0035705) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance
| - 29. SRC Family Tyrosine Kinase
- [Family of non-receptor protein-tyrosine kinases homologous to src. They are closely related intracellular enzymes that participate in signal transduction pathways in a variety of hemopoietic cells and especially their surface receptors. EC 2.7.1.-. ( NCI )] (UMLS (NCI) C0282625) =Amino Acid, Peptide, or Protein; Enzyme
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- 7. 40S Ribosomal Protein S19
- [Encoded by human RPS19 Gene (S19E Family), 144-aa 16-kDa cytoplasmic Ribosomal Protein S19 is a component of the 40S ribosomal subunit. S19 lacks cysteine residues and has a possible function in erythropoietic differentiation and proliferation. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. (NCI) ( NCI )] (UMLS (NCI) C0073320) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 30. SRD5A2
- [This gene is involved in androgen metabolism and sexual differentiation. ( NCI )] (UMLS (NCI) C0919429) SRD5A2 Gene;
Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) Gene =Gene or Genome ;
|
- 8. 40s Ribosomal Protein S27
- [Expressed in actively proliferating cells by human RPS27 Gene (S27E Family), 83-aa 9-kDa Ribosomal Protein S27 is located in the cytoplasm as a component of the 40S ribosomal subunit, but is also detected in the nucleus. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. S27 appears to be located near ribosomal protein S18 and to be covalently linked to translation initiation factor eIF3. S27 contains a C4-type zinc finger domain and is able to bind to nucleic acid. (NCI) ( NCI )] (UMLS (NCI) C0527863) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 31. SRM/SRR - Request addition of service/resource on appointment
- (UMLS (HL7) C1549350) =Health Care Activity =Event Type;
|
- 9. 40S Ribosomal Protein S3
- [Encoded by human RPS3 Gene (S3P Family), cytoplasmic and nuclear 243-aa 27-kDa Ribosomal Protein S3 contains a KH type-2 domain and is a component of the 40S ribosomal subunit as part of the translation initiation domain. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPS3 also appears to be an endonuclease involved in UV-induced DNA repair. (NCI) ( NCI )] (UMLS (NCI) C0073328) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 32. SRM/SRR - Request appointment cancellation
- (UMLS (HL7) C1549347) =Health Care Activity =Event Type;
|
- 10. 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D
- [An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C0753474) Cyclo((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-me;
SZD PSC 833;
Valspodar;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 33. SRM/SRR - Request appointment deletion
- (UMLS (HL7) C1549349) =Health Care Activity =Event Type;
|
- 11. 60S Ribosomal pProtein L19
- [Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L19, encoded by the RPL19 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink) ( NCI )] (UMLS (NCI) C0073283) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 34. SRM/SRR - Request appointment discontinuation
- (UMLS (HL7) C1549348) =Health Care Activity =Event Type;
|
- 12. 60S Ribosomal Protein L10
- [Encoded by human RPL10 Gene (L10E Family), down-regulated during adipocyte, kidney, and heart differentiation, 213-aa 24-kDa cytoplasmic Ribosomal Protein L10 is a component of the ribosomal 60S subunit. Ribosomes catalyze protein synthesis and consist of 40S and 60S subunits composed of 4 rRNAs and approximately 80 structurally distinct proteins. RPL10 may also bind to and repress c-Jun transcriptional activation. (NCI) ( NCI )] (UMLS (NCI) C0218544) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 35. SRM/SRR - Request appointment modification
- (UMLS (HL7) C1549346) =Health Care Activity =Event Type;
|
- 13. 60S Ribosomal Protein L13
- [Encoded by human RPL13 Gene (L13E Ribosomal Protein Family), highly conserved 210-amino acid 24 kD cytoplasmic Ribosomal Protein L13 is a ribosomal 60S subunit protein. The protein is highly basic with no signal or transmembrane sequence, but has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0245587) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 36. SRM/SRR - Request appointment rescheduling
- (UMLS (HL7) C1549345) =Health Care Activity =Event Type;
|
- 14. 60S Ribosomal Protein L7a
- [Encoded by human RPL7A Gene (L7AE Family), 265-aa 30-kDa Ribosomal Protein L7a is a component of the large 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. (NCI) ( NCI )] (UMLS (NCI) C0073263) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 37. SRM/SRR - Request cancellation of service/resource on appointment
- (UMLS (HL7) C1549352) =Health Care Activity =Event Type;
|
- 15. 60S Ribosomal Protein L8
- [Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L8, encoded by the RPL8 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink) ( NCI )] (UMLS (NCI) C0169360) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 38. SRM/SRR - Request deletion of service/resource on appointment
- (UMLS (HL7) C1549354) =Health Care Activity =Event Type;
|
- 16. 90Sr
- [A radioactive isotope of the heavy metal strontium, Strontium-90 is a by-product of uranium and plutonium fission. SR-90 is linked to bone, and other, cancers. Acting chemically in vivo like calcium, it tends to concentrate in bones and teeth. Used as a radioactive tracer in medical and agricultural studies, controlled amounts of strontium-90 have also been used as a treatment for bone cancer. (NCI04) ( NCI )] (UMLS (NCI) C0303547) =Element, Ion, or Isotope
| - 39. SRM/SRR - Request discontinuation of service/resource on appointment
- (UMLS (HL7) C1549353) =Health Care Activity =Event Type;
|
- 17. Sr
- [element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62. ( CSP )] (UMLS (NCI) C0038467) =Biologically Active Substance; Element, Ion, or Isotope ;
=alkaline earth metal;
heavy metal =strontium chloride;
| - 40. SRM/SRR - Request modification of service/resource on appointment
- (UMLS (HL7) C1549351) =Health Care Activity =Event Type;
|
- 18. SR 29142
- [A drug that may protect healthy tissue from the toxic effects of anticancer drugs. ( NCI )] (UMLS (NCI) C0338290) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
| - 41. SRM/SRR - Request new appointment booking
- (UMLS (HL7) C1549344) =Health Care Activity =Event Type;
|
- 19. SR 4233
- (UMLS (NCI) C0878536) SR4233;
=Organic Chemical; Pharmacologic Substance | - 42. SRPUL
- [Human Sushi-Repeat Protein is encoded by SRPUL Gene. (NCI) ( NCI )] (UMLS (NCI) C1308890) SRPX2;
Sushi-Repeat Containing Protein;
Sushi-Repeat Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 20. SR 49059
- [An anticancer drug that inhibits a hormone growth factor responsible for stimulating some cancer cells to multiply. ( NCI )] (UMLS (NCI) C0218069) =Organic Chemical; Pharmacologic Substance ;
| - 43. SRS (slow reacting substance)
- [A chemically diverse group of substances produced by various tissues in the body that cause slow contraction of smooth muscle; they have other intense but varied pharmacologic activities. ( MSH )] (UMLS (CSP) C0037343) =Biologically Active Substance
|
- 21. Sr element
- [ ] (UMLS (CSP) C0920768) Sr++ element =Element, Ion, or Isotope
| - 44. [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine
- [A microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage and bone marrow stem cell as well as stimulates release of interleukin-1 and -2, thus further enhances its antitumor activity. ( NCI )] (UMLS (NCI) C0053355) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
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- 22. SR-1530
- (UMLS (NCI) C1135157) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 45. [S-(R*,R*)]-3-Acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-2H-pyrrol-2-one
- [3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin. ( MSH )] (UMLS (NCI) C0039531) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
|
- 23. SR-2508
- (UMLS (NCI) C0740264) =Organic Chemical; Pharmacologic Substance
| - 46. [S-(R*,R*)]-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)-methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
- [A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. (NCI04) ( NCI )] (UMLS (NCI) C0039735) =Organic Chemical; Pharmacologic Substance ;
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