TAF12

[Ubiquitously expressed as alternative initiation isoforms by human TAF12 Gene (TAF2J Family), nuclear (18-kDa precursor) TBP-Associated Factor 15 kDa and 20 kDa, similar to Histones H2B and H3, are components of the TFIID complex essential for regulation of transcription. A component of the PCAF complex and the STAGA transcription coactivator-HAT complex, TAF12 interacts directly with TBP and TAF11, as well as with TAFII20 and TAFII30. TFIID is composed of TBP and many TAF proteins. Control of transcription by the RNA polymerase II basal transcription machinery complex is modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to transcription start sites. Some modulators interact directly with the basal complex; others may bridge transactivators to the basal factors. Different TAFs may mediate distinct transcriptional activators. (NCI) ( NCI )]

UMLS (NCI) C1173190

TAF12 RNA Polymerase II
TAF2J
TAFII20
TATA Box Binding Protein-Associated Factor 20kDa
TATA Box Binding Protein-Associated Factor RNA Polymerase II J 20kD
TBP-Associated Factor 20 kDa
TBP-Associated Factor RNA Polymerase II J 20kD
Transcription Initiation Factor TFIID 20 kDa Subunit

Amino Acid, Peptide, or Protein
Biologically Active Substance

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