[STAT proteins have the dual function of signal transduction and activation of transcription. These proteins are activated by phosphorylation on tyrosine in response to different ligands after which they form homodimers or heterodimers that translocate to the cell nucleus where they either directly bind to DNA or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (from OMIM 600555) ( NCI )]
UMLS (NCI) C1366753STAT
STAT Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance