[This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this protein in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink) ( NCI )]
UMLS (NCI) C0297890 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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