[Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink) ( NCI )]
UMLS (NCI) C0079091 - Amino Acid, Peptide, or Protein
- Immunologic Factor
- Receptor
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