- 1. ALK
- [The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. (LocusLink) ( NCI )] (UMLS (NCI) C0252409) =Amino Acid, Peptide, or Protein; Enzyme
| - 20. Alkanesulfonates
- [any compound of the type R-SO3-. ( CSP )] (UMLS (NCI) C0002072) =Organic Chemical
|
- 2. ALK
- [This gene is involved in brain development and neuronal specificity. ( NCI )] (UMLS (NCI) C1332080) ALK Gene;
Anaplastic Lymphoma Kinase (Ki-1) Gene;
=Gene or Genome | - 21. Alkansea
- (UMLS (HL7) C1551966) Arkansas;
=Language =Dhegiha;
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- 3. ALK-DLBCL
- (UMLS (NCI) C1333294) Diffuse Large B-Cell Lymphoma with Expression of Full-Length ALK;
Diffuse Large B-Cell Lymphoma with Expression of Full-Length Anaplastic Lymphoma Kinase;
=Neoplastic Process ;
| - 22. alkene
- [unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. ( CSP )] (UMLS (CSP) C0002068) =Organic Chemical
|
- 4. ALK-Negative Anaplastic Large Cell Lymphoma
- (UMLS (NCI) C1332078) =Neoplastic Process
| - 23. Alkeran
- (UMLS (NCI) C0591063) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 5. Alka Seltzer
- (UMLS (NCI) C0051166) =Pharmacologic Substance
| - 24. ALKoma
- (UMLS (NCI) C1332079) ALK-Positive Anaplastic Large Cell Lymphoma =Neoplastic Process
|
- 6. ALKAL BURN CORNEA/CONJUN
- [ ] (UMLS (ICD9CM) C0161030) =Injury or Poisoning
| - 25. alkyl group
- [any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons. ( CSP )] (UMLS (CSP) C0596066) =Organic Chemical ;
=chemical group;
=methyl group;
|
- 7. alkali metal
- [metals that constitute group 1(formerly group Ia) of the periodic table; they are the most strongly electropositive of the metals; note that hydrogen is not considered an alkali metal even though it falls under the group 1 heading in the periodic table. ( CSP )] (UMLS (CSP) C0025554) =Element, Ion, or Isotope =Element;
metal =cesium;
Li element;
[TN403] POTASSIUM;
Rb element;
[TN404] SODIUM;
[TN403] POTASSIUM;
Rb element;
[TN404] SODIUM | - 26. alkyl nitrile
- [ ] (UMLS (CSP) C0596067) =Organic Chemical; Hazardous or Poisonous Substance =cyanide;
=CNBr;
beta aminopropionitrile |
- 8. alkaline earth metal
- [bivalent metals that constitute the group 2 (formerly group IIa) of the periodic table; they are Be, Mg, Ca, Sr, Ba and Ra. ( CSP )] (UMLS (CSP) C0025555) =Element, Ion, or Isotope =Element;
metal =Ba;
Be;
[TN402] CALCIUM;
[TN406] MAGNESIUM;
Sr;
[TN402] CALCIUM;
Sr;
| - 27. alkyl substitution
- [ ] (UMLS (CSP) C0598140) =Molecular Function ;
|
- 9. alkaline phosphatase
- [An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum. ( NCI )] (UMLS (CSP) C0002059) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 28. Alkyl-Guanine Transferase Inhibitor
- [Substances that inhibit 06-Alkylguanine-DNA Alkyltransferase, a DNA repair enzyme, and interferes with the enzymes ability to remove alkyl adducts from DNA. ( NCI )] (UMLS (NCI) C1510851) O6-Alkylguanine-DNA Alkyltransferase Inhibitor;
O6-Alkylguanine-DNA Alkyltransferase Inhibitors =Pharmacologic Substance ;
|
- 10. Alkaline Phosphatase
- [A quantitative measurement of alkaline phosphatase present in a sample. ( NCI )] (UMLS (NCI) C0201850) =Laboratory Procedure
| - 29. Alkylating Agent Related Acute Myeloid Leukemia
- (UMLS (NCI) C1332233) Alkylating Agent-Related Acute Myeloid Leukemia;
Alkylating Agent-Related AML =Neoplastic Process ;
|
- 11. alkalinity
- [ ] (UMLS (CSP) C0597742) =Quantitative Concept ;
| - 30. Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome
- (UMLS (NCI) C1332234) Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome;
Alkylating Agent-Related AML and MDS =Neoplastic Process ;
|
- 12. alkalinization
- [(AL-ka-LIN-ih-ZAY-shun) The process by which a substance becomes an alkali. An alkali is the opposite of an acid. ( NCI )] (UMLS (NCI) C1510847) =Molecular Function ;
| - 31. Alkylating Agent Related Myelodysplastic Syndrome
- (UMLS (NCI) C1332235) Alkylating Agent-Related Myelodysplastic Syndrome;
=Neoplastic Process ;
|
- 13. Alkalinizing Agent Preparation
- [Used topically or systemically for management of metabolic acidosis, improved muscle contraction, and hyper-acidic conditions, Alkalinizing Agent Preparations contain one or more substances with basic properties, such as sodium bicarbonate, sodium citrate, and phosphate salts (potassium phosphate, sodium acid phosphate, and tribasic sodium phosphate). Usually the alkalinizing agent(s) acts as a proton acceptor, neutralizing the acidity of a biologic environment (skin, gastric content, urine, etc.) and raising the pH. (NCI04) ( NCI )] (UMLS (NCI) C1510848) =Pharmacologic Substance ;
| - 32. alkylation
- [substitution of an alkyl group for an active hydrogen atom in an organic compound. ( CSP )] (UMLS (CSP) C0002074) =Natural Phenomenon or Process
|
- 14. Alkalization
- (UMLS (HL7) C1550103) =Therapeutic or Preventive Procedure ;
=Therapeutic Interventions;
◊ [The act rendering alkaline by impregnating with an alkali; a conferring of alkaline qualities. ( HL7V3.0 )] (UMLS (HL7) C1551382) Laboratory Procedure ActSpecimenTreatmentCode; | - 33. alkylphosphate
- [metabolites of organophosphate pesticides. ( CSP )] (UMLS (CSP) C0596068) =Organophosphorus Compound ;
=phosphate;
=DFP;
EHDP |
- 15. alkaloid
- [organic nitrogenous bases; many alkaloids of medical importance occur in the animal and vegetable kingdoms. ( CSP )] (UMLS (CSP) C0002062) =Organic Chemical
| - 34. Alkylphosphocholine
- [A class of ether-linked lysophosphatidylcholines with potential antineoplastic activity. Exhibiting anti-proliferative and immunomodulatory properties, alkyl-phosphocholine compounds modulate cell membrane permeability, phospholipid metabolism, and intracellular growth signal transduction pathways and induce cytotoxic macrophages, cell differentiation, and apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C1510852) Alkylphosphocholine Compound;
Alkylphospholipid;
Alkylphospholipids;
APC =Pharmacologic Substance ;
|
- 16. Alkaloid Biosynthesis I
- (UMLS (NCI) C1510850) Alkaloid Biosynthesis I Pathway;
=Molecular Function ;
| - 35. alkyltransferase
- [heterogeneous class of enzymes transferring alkyl or related groups either substituted or unsubstituted. ( CSP )] (UMLS (CSP) C0524999) =Amino Acid, Peptide, or Protein; Enzyme =EC 2;
=EC 2.5.1.18;
methionine adenosyltransferase |
- 17. Alkaloid Biosynthesis II
- (UMLS (NCI) C1510849) Alkaloid Biosynthesis II Pathway;
=Molecular Function ;
| - 36. Alkyltransferase and Aryltransferase
- [Alkyltransferases and Aryltransferases are classes of enzymes that transfer an alkyl or aryl chemical group from one compound (the donor) to another compound (the acceptor). Alkyls are radicals derived from an aliphatic hydrocarbon by removal of a hydrogen atom. Aryl are radicals derived from an aromatic compound by removal of a hydrogen atom. ( NCI )] (UMLS (NCI) C1332236) EC 2.5;
=Amino Acid, Peptide, or Protein; Enzyme |
- 18. alkalosis
- [pathological condition that removes acid or adds base to the body fluids. ( CSP )] (UMLS (CSP) C0002063) =Disease or Syndrome
| - 37. alkyne
- [unsaturated hydrocarbon containing a triple bond between two carbon atoms; the alkynes are members of the acetylene series. ( CSP )] (UMLS (CSP) C0002078) =Organic Chemical
|
- 19. alkane
- [generic name for the group of aliphatic hydrocarbons Cn-H2n+2; they are denoted by the suffix -ane. ( CSP )] (UMLS (CSP) C0002065) =Organic Chemical
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