S S S- S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 SA SB SC SD SE SF SG SH SI SJ SK SL SM SN SO SP SQ SR SS ST SU SV SW SY
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride
[An oral formulation of hydrochloride salt of topotecan, a semisynthetic derivative of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Compared to intravenously administered topotecan, the oral formulation is a more convenient way of administering this agent. ( NCI )]
UMLS (NCI) C0886549Hycamptamine
Oral Topotecan Hydrochloride
Topotecan HCl
Topotecan hydrochloride
topotecan hydrochloride (oral)
TOPOTECAN HYDROCHLORIDE PREPARATION
Oral Topotecan Hydrochloride
Topotecan HCl
Topotecan hydrochloride
topotecan hydrochloride (oral)
TOPOTECAN HYDROCHLORIDE PREPARATION
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
Relation/CHD: TOPOTECAN HYDROCHLORIDE 4 MG
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