S S S- S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 SA SB SC SD SE SF SG SH SI SJ SK SL SM SN SO SP SQ SR SS ST SU SV SW SY
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
[A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. ( NCI )]
UMLS (NCI) C0040233- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Propanolamines
[CV100] BETA-BLOCKERS/RELATED
[OP101] BETA-BLOCKERS, TOPICAL OPHTHALMIC
[OP109] ANTIGLAUCOMA, OTHER
[CV100] BETA-BLOCKERS/RELATED
[OP101] BETA-BLOCKERS, TOPICAL OPHTHALMIC
[OP109] ANTIGLAUCOMA, OTHER
Relation/CHD: TIMOLOL MALEATE
TIMOLOL HEMIHYDRATE
TIMOLOL MALEATE
TIMOLOL HEMIHYDRATE
TIMOLOL HEMIHYDRATE
TIMOLOL MALEATE
TIMOLOL HEMIHYDRATE
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