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(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
[An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at G2-M phase and leads to apoptosis of fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation is a less cumbersome way of administering this agent. ( NCI )]
UMLS (NCI) C1135132Azaepothilone B
Epothilone
IXABEPILONE
Oral Ixabepilone
Epothilone
IXABEPILONE
Oral Ixabepilone
- Organic Chemical
- Pharmacologic Substance
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