- 4701. Amlodipine Besylate/Benazepril Hydrochloride
- [Having a substantial blood pressure lowering capability, Amlodipine Besylate Benazepril Hydrochloride contains a dihydropyridine calcium blocker (amlodipine) and an angiotensin-converting enzyme (ACE) inhibitor (benazepril). A long-acting calcium channel antagonist, Amlodipine inhibits transmembrane calcium influx into vascular smooth muscle. Blocking ACE, Benazepril decreases vasopressive plasma angiotensin II. (NCI04) ( NCI )] (UMLS (NCI) C1302063) =Organic Chemical; Pharmacologic Substance ;
| - 4751. AMOPLACE
- (UMLS (NCI) C0279970) =Therapeutic or Preventive Procedure
|
- 4702. AMLODIPINE MALEATE
- [The maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug response activity through inhibition of the p-glycoprotein efflux pump. ( NCI )] (UMLS (NCI) C0886700) =Organic Chemical; Pharmacologic Substance ;
| - 4752. amorphous solid
- [solid with no regularity in the arrangement of its molecular constituents. ( CSP )] (UMLS (CSP) C0596083) =Chemical Viewed Structurally ;
=solid state;
|
- 4703. Ammon's horn
- [a layer of gray matter lying along the floor of the lateral ventricle of the brain, comprised of cholinergic and possibly glutamatergic fibers, believed to be the critical brain structure underlying learning and memory. ( CSP )] (UMLS (CSP) C0019564) =Body Part, Organ, or Organ Component ;
=limbic system;
=dentate gyrus | - 4753. Amosite Asbestos
- [A naturally occurring, fibrous amphibole asbestos mineral with a color ranging from gray to greenish-brown. Amosite is used extensively in industry for various purposes. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Amosite asbestos is a known human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0051740) =Hazardous or Poisonous Substance; Inorganic Chemical
|
- 4704. ammonia
- [colorless alkaline gas formed in the body during decomposition of organic materials during a large number of metabolically important reactions. ( CSP )] (UMLS (CSP) C0002607) =Biologically Active Substance; Inorganic Chemical
| - 4754. Amount
- (UMLS (HL7) C1561574) =Intellectual Product =Amount class;
|
- 4705. ammonia lyase
- [Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1. ( MSH )] (UMLS (CSP) C0002610) =Amino Acid, Peptide, or Protein; Enzyme
| - 4755. Amount
- [How much there is of something that you can measure; the total amount or number. ( NCI )] (UMLS (NCI) C1265611) Quantity =Quantitative Concept
|
- 4706. ammonia poisoning
- [ ] (UMLS (CSP) C0597829) =Injury or Poisoning
| - 4756. Amount class
- (UMLS (HL7) C1547609) =Quantitative Concept =HL7 Vocabulary Version 2.5;
=%;
Limit;
Unlimited;
Amount;
|
- 4707. Ammonium 5-Tungsto-2-antimonate
- (UMLS (NCI) C0103100) =Pharmacologic Substance; Inorganic Chemical
| - 4757. Amount of Substance Unit
- [Physical quantity that measures the number of elementary entities in the object compared with the number of elementary entities (atoms, molecules, ions, electrons, or particles) in 0.012 kilogram of pure carbon-12. ( NCI )] (UMLS (NCI) C0439149) =Quantitative Concept
|
- 4708. ammonium compound
- [inorganic and organic compounds that contain the radical NH4 or ammonium. ( CSP )] (UMLS (CSP) C0002616) =Chemical Viewed Structurally ;
| - 4758. Amount type
- (UMLS (HL7) C1550420) =Classification =HL7 Vocabulary Version 2.5;
=Differential;
Rate;
Unlimited;
Percentage;
Limit |
- 4709. Ammonium heparin
- (UMLS (HL7) C1550071) =Organic Chemical; Biomedical or Dental Material ;
=Additive/Preservative;
| - 4759. AMOX
- [An antibiotic drug used to treat infection. It belongs to the family of drugs called penicillins or penicillin derivatives. ( NCI )] (UMLS (NCI) C0002645) =Organic Chemical; Antibiotic
|
- 4710. Ammonium heparin
- [Ammonium heparin ( HL7V3.0 )] (UMLS (HL7) C1561472) =Intellectual Product =MaterialEntityAdditive;
| - 4760. AMOX/CLARITH/OMEP
- (UMLS (NCI) C0677814) =Therapeutic or Preventive Procedure
|
- 4711. Ammonium N-hydroxy-N-nitrosobenzenamine
- [A creamy, white crystalline substance. Cupferron is used as an analytical reagent to separate copper, iron and vanadium from other metals. Exposure to this substance causes gastrointestinal disturbances and skin, eye and respiratory-tract irritation. Cupferron is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0056590) =Organic Chemical
| - 4761. AMOXAPINE
- [A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent. ( NCI )] (UMLS (NCI) C0002644) =Organic Chemical; Pharmacologic Substance
|
- 4712. Ammunition
- [A complete device charged with explosives, propellants, pyrotechnics, initiating composition, or nuclear, biological, or chemical material for use in military operations, including demolitions. ( NCI )] (UMLS (NCI) C0336683) =Manufactured Object
| - 4762. Amoxicillin-Clavulanate Potassium
- [A fixed combination of Amoxicillin and Clavulanic Acid, which inhibits beta-lactamase, a bacterial enzyme that inactivates amoxicillin. ( NCI )] (UMLS (NCI) C0054066) =Organic Chemical; Antibiotic ;
|
- 4713. AMN
- [A synthetic or natural carcinogenic compound found in a variety of smokes and industrial products, N-Amyl-N-Methylnitrosoamine is used in biomedical research to induce experimental hepatocarcinogenesis, probably through abnormal DNA methylation. (NCI04) ( NCI )] (UMLS (NCI) C0067813) =Organic Chemical; Hazardous or Poisonous Substance
| - 4763. Amoxicillin-Clavulanate Potassium/Ciprofloxacin
- (UMLS (NCI) C1327981) =Therapeutic or Preventive Procedure ;
|
- 4714. amnesia
- [Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories. ( NCI )] (UMLS (CSP) C0002622) =Mental or Behavioral Dysfunction ;
| - 4764. Amoxil
- (UMLS (NCI) C0700524) =Organic Chemical; Antibiotic ;
|
- 4715. AMNESTIC DISORD OTH DIS
- (UMLS (ICD9CM) C0002625) =Mental or Behavioral Dysfunction ;
| - 4765. AMP
- [A container capable of being hermetically sealed, intended to hold sterile materials. ( NCI )] (UMLS (NCI) C0179031) =Medical Device
|
- 4716. amniocentesis
- [percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid; it is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions. ( CSP )] (UMLS (CSP) C0002627) =Diagnostic Procedure ;
| - 4766. Amp
- [Encoded by human AMPH Gene (Amphiphysin Family), 695-amino acid Amphiphysin isoforms of 128- and 108 kD are expressed in neurons, certain endocrine cells, and spermatocytes. The protein may regulate synaptic and endocrine exocytosis. Heterodimeric with AMPHL, AMPH is a non-intrinsic acidic membrane protein concentrated in nerve terminals and associated with the cytoplasmic face of synaptic vesicles. The N- and C-termini are highly conserved between chicken and human; the C-terminal region contains an SH3 domain. AMPH may control membrane associated cytoskeleton properties and protein dysfunction is associated with Stiff-Man Syndrome. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1458148) AMPH;
Amphiphysin;
Stiff-Mann Syndrome with Breast Cancer 128kD Autoantigen;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4717. Amniocentesis (consent & refusal)
- (UMLS (HL7) C1548812) =Health Care Activity =Consent Type;
| - 4767. AMP BELOW ELB, UNIL-COMP
- [ ] (UMLS (ICD9CM) C0160635) =Injury or Poisoning
|
- 4718. AMNIOINFUSION
- [ ] (UMLS (ICD9CM) C0262671) =Therapeutic or Preventive Procedure ;
| - 4768. AMPA (amino 3 hydroxy 5 methylisoxazole 4 propionate)
- [ ] (UMLS (CSP) C0598410) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 4719. amnion
- [extraembryonic membrane which contains the embryo and amniotic fluid. ( CSP )] (UMLS (CSP) C0002630) =Embryonic Structure ;
| - 4769. AMPA 3
- [Subunit 3 of the AMPA subtype of ionotropic glutamate receptor; important for excitatory neurotransmission ( NCI )] (UMLS (NCI) C1334286) Glutamate Receptor, Ionotrophic, AMPA 3;
GRIA3;
=Amino Acid, Peptide, or Protein; Receptor |
- 4720. AMNION PROB NEC-ANTEPART
- [ ] (UMLS (ICD9CM) C0157161) =Disease or Syndrome
| - 4770. AMPA receptor
- [subtype of glutamate receptor activated by alpha-amino-5-methyl isoxazole-4-propionate (AMPA); mediates rapid, excitatory signalling between central neurons; capable of rapid desensitization. ( CSP )] (UMLS (CSP) C0072899) =Amino Acid, Peptide, or Protein; Receptor =glutamate receptor;
|
- 4721. AMNION PROB NOS-ANTEPART
- [ ] (UMLS (ICD9CM) C0157165) =Disease or Syndrome
| - 4771. amperage
- [ ] (UMLS (CSP) C0598350) =Quantitative Concept ;
|
- 4722. Amnionitis
- [Inflammation of the amnion. ( NCI )] (UMLS (NCI) C0002631) =Disease or Syndrome ;
| - 4772. Ampere second
- [The SI derived unit of quantity of electricity, equal to the quantity of charge transferred in one second across a conductor in which there is a constant current of one ampere. ( NCI )] (UMLS (NCI) C0562424) =Quantitative Concept ;
=UnitOfMeasureAtomBaseUnitSens;
UnitOfMeasureAtomBaseUnitInsens |
- 4723. AMNIOSCOPY
- (UMLS (ICD9CM) C0002632) =Diagnostic Procedure ;
| - 4773. AMPH
- [This gene is involved in endocytosis and synaptic transmission. ( NCI )] (UMLS (NCI) C1332086) AMPH Gene;
Amphiphysin (Stiff-Man Syndrome with Breast Cancer 128kDa Autoantigen) Gene;
=Gene or Genome ;
|
- 4724. AMNIOT EMBOL-DELIV W P/P
- [ ] (UMLS (ICD9CM) C0157549) =Disease or Syndrome
| - 4774. AMPHETAMIN DEPEND-CONTIN
- [ ] (UMLS (ICD9CM) C0154492) =Mental or Behavioral Dysfunction
|
- 4725. AMNIOTC ASP W/O RESP SYM
- [ ] (UMLS (ICD9CM) C1561794) Aspiration of clear amniotic fluid without respiratory symptoms;
=Pathologic Function | - 4775. AMPHETAMIN DEPEND-EPISOD
- [ ] (UMLS (ICD9CM) C0154493) =Mental or Behavioral Dysfunction
|
- 4726. AMNIOTIC ASP W RESP SYM
- [ ] (UMLS (ICD9CM) C1561796) Aspiration of clear amniotic fluid with respiratory symptoms;
=Pathologic Function | - 4776. AMPHETAMIN DEPEND-REMISS
- [ ] (UMLS (ICD9CM) C0154494) =Mental or Behavioral Dysfunction
|
- 4727. Amniotic Cavity
- (UMLS (NCI) C0230976) =Body Space or Junction
| - 4777. AMPHETAMIN DEPEND-UNSPEC
- [ ] (UMLS (ICD9CM) C0375175) =Mental or Behavioral Dysfunction
|
- 4728. AMNIOTIC EMBOL-ANTEPART
- [ ] (UMLS (ICD9CM) C0157550) =Disease or Syndrome
| - 4778. AMPHETAMINE ABUSE-CONTIN
- [ ] (UMLS (ICD9CM) C0154537) =Mental or Behavioral Dysfunction
|
- 4729. AMNIOTIC EMBOL-POSTPART
- [ ] (UMLS (ICD9CM) C0157551) =Disease or Syndrome
| - 4779. AMPHETAMINE ABUSE-EPISOD
- [ ] (UMLS (ICD9CM) C0154538) =Mental or Behavioral Dysfunction
|
- 4730. AMNIOTIC EMBOLISM-DELIV
- [ ] (UMLS (ICD9CM) C0157548) =Acquired Abnormality
| - 4780. AMPHETAMINE ABUSE-REMISS
- [ ] (UMLS (ICD9CM) C0154539) =Mental or Behavioral Dysfunction
|
- 4731. AMNIOTIC EMBOLISM-UNSPEC
- [Blocking of maternal circulation by AMNIOTIC FLUID that is forced into uterine VEINS by strong UTERINE CONTRACTION near the end of pregnancy. It is characterized by the sudden onset of severe respiratory distress and HYPOTENSION that can lead to maternal DEATH. ( MSH )] (UMLS (ICD9CM) C0013927) =Disease or Syndrome =embolism;
Pregnancy Complications, Cardiovascular | - 4781. AMPHETAMINE ABUSE-UNSPEC
- [ ] (UMLS (ICD9CM) C0375184) =Mental or Behavioral Dysfunction
|
- 4732. amniotic fluid
- [amniotic cavity fluid which is produced by the amnion and fetal lungs and kidneys. ( CSP )] (UMLS (CSP) C0002638) =Body Substance ;
| - 4782. Amphetamine Aspartate
- [The aspartate salt of amphetamine, a sympathomimetic amine with CNS stimulating properties. Amphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. Physiological effects include an increase in motor activity, euphoria, increased mental alertness, excitatory behavior and appetite suppression. ( NCI )] (UMLS (NCI) C0724524) AMPHETAMINE ASPARTATE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=Amfetamine;
=AMPHETAMINE ASPARTATE 7.5 MG;
AMPHETAMINE ASPARTATE 5 MG;
AMPHETAMINE ASPARTATE 1.25 MG |
- 4733. Amniotic fluid
- (UMLS (HL7) C1546538) =Intellectual Product =Specimen Source Codes;
| - 4783. Amphetamine or related acting sympathomimetic abuse
- [ ] (UMLS (ICD9CM) C0154536) =Mental or Behavioral Dysfunction
|
- 4734. Amniotic fluid
- (UMLS (HL7) C1610731) =Body Substance =SpecimenEntityType;
| - 4784. Amphiarthrosis
- [A form of articulation in which the bones are connected by intervening substance admitting slight motion. ( NCI )] (UMLS (NCI) C0224520) =Body Space or Junction
|
- 4735. AMNIOTIC INFECT-ANTEPART
- [ ] (UMLS (ICD9CM) C0157158) =Disease or Syndrome
| - 4785. Amphibia
- [cold blooded chordates; larva are usually aquatic, breathing by gills; adults are terrestrial or aquatic, breathing by lungs and through moist glandular skin. ( CSP )] (UMLS (CSP) C0002668) =Amphibian
|
- 4736. AMNIOTIC INFECTION-DELIV
- [ ] (UMLS (ICD9CM) C0157157) =Disease or Syndrome
| - 4786. Amphipathic Alpha Helix
- [The amphipathic helix motif is characterized by a repeating pattern of polar (P) and non-polar (N) side-chains that can be summarized as PxNPPNx. These clusters varied in length from 6 to 15 residues. The conserved non-polar positions are marked by a distinct absence of Asp, Asn and Ser, while other polar side chains are sometimes allowed. ( NCI )] (UMLS (NCI) C1510874) =Amino Acid Sequence ;
|
- 4737. AMNIOTIC PROB NEC-DELIV
- [ ] (UMLS (ICD9CM) C0157160) =Disease or Syndrome
| - 4787. amphiphilicity
- [property of a hydrophobic face or pole and a hydophilic face or pole in the same molecule, leading to important phase phenomena such as bilayer formation by phospholipids; amphiphilic protein alpha helices may fold to expose their hydrophilic faces in soluble proteins, hydrophobic in membrane-bound. ( CSP )] (UMLS (CSP) C0596084) =Qualitative Concept ;
=Chemical Properties;
|
- 4738. AMNIOTIC PROB NEC-UNSPEC
- [ ] (UMLS (ICD9CM) C0157159) =Disease or Syndrome
| - 4788. Amphiphysin II
- [Encoded as ten alternate splicing variant isoforms by human BIN1 Gene, ubiquitously expressed nucleocytoplasmic adaptor protein Bridging Integrator 1 exhibits differential binding to dynamin, synaptojanin (via sh3 domain), alpha-adaptin, endophilin, clathrin, and MYC protein. BIN1 interacts with the MYC N-transactivation domain in a manner requiring the conserved MYC box regions 1 and 2. Some isoforms may play a role in protein targeting during synaptic vesicle endocytosis. BIN1 contains a BAR domain and an SH3 domain and may be phosphorylated by protein kinase C. (NCI) ( NCI )] (UMLS (NCI) C0529765) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 4739. AMNIOTIC PROB NOS-DELIV
- [ ] (UMLS (ICD9CM) C0157164) =Disease or Syndrome
| - 4789. Amphipoda
- [An order of mostly marine CRUSTACEA containing more than 5500 species in over 100 families. Like ISOPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Isopoda, they possess thoracic gills and their bodies are laterally compressed. ( MSH )] (UMLS (CSP) C0598804) =Invertebrate ;
|
- 4740. AMNIOTIC PROB NOS-UNSPEC
- [ ] (UMLS (ICD9CM) C0157163) =Disease or Syndrome
| - 4790. amphiregulin
- [Amphiregulin is a heparin-binding, heparin-inhibited member of the epidermal growth factor family and an autocrine growth factor for human keratinocytes. It seems to play an important role in mammary epithelial cell growth regulation. It shows overexpression in various tumors. It is encoded by the AREG gene. ( NCI )] (UMLS (CSP) C0051755) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 4741. Amniotic Sac
- (UMLS (NCI) C0883994) =Body Part, Organ, or Organ Component ;
=Body Part;
| - 4791. Amphiregulin (Schwannoma-Derived Growth Factor) Gene
- [This gene plays a role in the regulation of epithelial cell growth. ( NCI )] (UMLS (NCI) C1332109) AREG;
AREG Gene =Gene or Genome ;
|
- 4742. Amniotic Surface of Placenta
- (UMLS (NCI) C1510873) Amniotic Surface of the Placenta;
=Embryonic Structure ;
| - 4792. Amphiregulin-Associated Protein
- [NEGF2 is a member of a highly conserved, developmentally regulated human gene family. The gene product exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Expression of NEGF2 is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. The gene codes for a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. ( NCI )] (UMLS (NCI) C0083453) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 4743. AmnioticFluidSacRoute
- [Amniotic fluid sac ( HL7V3.0 )] (UMLS (HL7) C1698907) =Functional Concept =RouteBySite;
=Injection, amniotic fluid;
| - 4793. Amphiuma
- [ ] (UMLS (CSP) C0002673) =Amphibian
|
- 4744. amobarbital
- [A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) ( MSH )] (UMLS (CSP) C0002640) =Organic Chemical; Pharmacologic Substance
| - 4794. Amphocil
- (UMLS (NCI) C0700958) =Organic Chemical; Antibiotic ;
|
- 4745. AMODIAQUINE
- [An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites. ( NCI )] (UMLS (NCI) C0002641) =Organic Chemical; Pharmacologic Substance
| - 4795. Amphotericin B Deoxycholate
- [The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. ( NCI )] (UMLS (NCI) C0051761) =Organic Chemical; Pharmacologic Substance
|
- 4746. Amodiaquine Hydrochloride
- [The hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites. ( NCI )] (UMLS (NCI) C0982016) AMODIAQUINE HYDROCHLORIDE PREPARATION;
=Organic Chemical; Pharmacologic Substance =AMODIAQUINE;
| - 4796. Amphotericin B/5-FC
- (UMLS (NCI) C0280635) =Therapeutic or Preventive Procedure
|
- 4747. Amoeba
- [A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission. ( MSH )] (UMLS (CSP) C0002642) =Invertebrate ;
| - 4797. amphotericin B/colistin sulfate/TBM
- (UMLS (NCI) C0281175) =Therapeutic or Preventive Procedure ;
|
- 4748. amol/mcL
- [A unit of concentration (molarity unit) equal to one trillionth of a mole (10E-12 mole) in one liter of solution. ( NCI )] (UMLS (NCI) C0439284) =Quantitative Concept
| - 4798. Amphoterin
- [HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221) ( NCI )] (UMLS (NCI) C0019796) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 4749. amol/nL
- [A unit of concentration (molarity unit) equal to one billionth of a mole (10E-9 mole) of solute in one liter of solution. ( NCI )] (UMLS (NCI) C0439282) =Quantitative Concept
| - 4799. Ampicillin Sodium/Sulbactam Sodium
- [A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria. ( NCI )] (UMLS (NCI) C1510875) =Organic Chemical; Antibiotic
|
- 4750. amol/pL
- [LITERAL ( NCI )] (UMLS (NCI) C0439300) =Quantitative Concept
| - 4800. Ampligen
- [A synthetic derivative of inosinic acid with antiretroviral and immunomodulatory properties. Atvogen acts through a number of pathways to stimulate intracellular antiviral activity of the immune system: it stimulates interferon production; activates the oligoadenylate synthase-RNase L pathway; stimulates natural killer cell activity; and acts as a non-mitogenic stimulator of the immune system. This agent also inhibits replication of human immunodeficiency virus (HIV) in vitro. (NCI04) ( NCI )] (UMLS (NCI) C0051764) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
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