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1. OGX-011
[A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of OGX-011 abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance. (NCI04) ( NCI )] (UMLS (NCI) C1328699) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;

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