- 1. (+-)-15-Deoxyspergualin
- [A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04) ( NCI )] (UMLS (NCI) C0284559) =Organic Chemical; Pharmacologic Substance ;
| - 26. deoxyadenosine
- [adenosine molecule which can be substituted in any position, but is lacking one hydroxyl group in the ribose part of the molecule. ( CSP )] (UMLS (CSP) C0242246) =Nucleic Acid, Nucleoside, or Nucleotide =deoxyribonucleoside;
adenine nucleoside =2CDA |
- 2. (-)-2'-Deoxy-5-fluoro-3'-thiacytidine
- (UMLS (NCI) C0877876) =Nucleic Acid, Nucleoside, or Nucleotide
| - 27. deoxyadenosylcobalamin
- [ ] (UMLS (CSP) C0598186) =Organic Chemical; Vitamin ;
|
- 3. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
- [antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. ( CSP )] (UMLS (NCI) C0016343) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
[AM800] ANTIVIRALS;
deoxyuridine;
fluoropyrimidine;
halocarbon compound;
nucleoside analog;
=FLOXURIDINE 100 MG/ML;
| - 28. deoxycorticosterone
- [21-hydroxypregn-4-ene-3,20-dione; a mineralocorticoid normally produced in small quantities by the adrenal cortex, used as replacement therapy in Addison's Disease. ( CSP )] (UMLS (CSP) C0011710) =Steroid; Pharmacologic Substance; Hormone =[HS052] MINERALOCORTICOIDS;
Pregnenediones;
TO BE DELETED INGREDIENT PREPARATIONS;
=deoxycortone pivalate;
Desoxycorticosterone Acetate;
|
- 4. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil
- [pyrimidine analog which inhibits viral DNA synthesis. ( CSP )] (UMLS (NCI) C0020811) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
deoxyuridine;
halocarbon compound;
[OP203] ANTIVIRALS, TOPICAL OPHTHALMIC;
nucleoside analog;
| - 29. deoxycytidine
- [nucleoside component of DNA; composed of cytosine and deoxyribose. ( CSP )] (UMLS (CSP) C0011485) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
=cytidine;
deoxyribonucleoside;
cytosine nucleoside;
=1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose;
5 fluorodeoxycytidine;
2',3'-Dideoxycytidine;
1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose;
5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine;
|
- 5. 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein
- [A synthetic C-terminal octapeptide identical to the sequences of the endogenous cholecystokinin hormone. Mimic action of cholecystokinin, sincalide induces gallbladder smooth muscle contraction directly, thereby reducing gallbladder size, inducing bile evacuation, and secretion of pancreatic enzymes. In addition, this agent decreases esophageal sphincter tone and delays gastric emptying via cholinergic signaling. ( NCI )] (UMLS (NCI) C0037167) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =CCK;
[DX101] NON-IONIC CONTRAST MEDIA =SINCALIDE 5 MCG;
| - 30. deoxyephedrine
- [sympathomimetic amine closely related chemically to both amphetamine and ephedrine, with actions similar to those of amphetamine; abuse may lead to dependence. ( CSP )] (UMLS (CSP) C0025611) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Amfetamine;
[CN801] AMPHETAMINES =BENZPHETAMINE;
Benzeneethanamine, N,alpha-dimethyl-, Hydrochloride(9CI);
|
- 6. 1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)
- [The meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography. The iodine moiety of diatrizoate meglumine is not penetrable by X-rays, therefore blocks the X-ray film exposure by radiation. This makes it possible to distinguish on X-ray film, body parts that contain diatrizoate meglumine from body parts that do not contain this agent and allows for visualization of different body structures. ( NCI )] (UMLS (NCI) C0012005) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid;
MEGLUMINE;
Triiodobenzoic Acids;
=3,5-Diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt;
DIATRIZOATE MEGLUMINE 520 MG/ML;
DIATRIZOATE MEGLUMINE 52 %;
DIATRIZOATE MEGLUMINE 660 MG;
DIATRIZOATE MEGLUMINE 76 %;
DIATRIZOATE MEGLUMINE 34.3 %;
DIATRIZOATE MEGLUMINE 30 %;
DIATRIZOATE MEGLUMINE 85 %;
DIATRIZOATE MEGLUMINE 52.7 %;
DIATRIZOATE MEGLUMINE 18 %;
DIATRIZOATE MEGLUMINE 60 %;
DIATRIZOATE MEGLUMINE 28.5 %;
DIATRIZOATE MEGLUMINE 66 %;
DIATRIZOATE MEGLUMINE 50 % | - 31. deoxyglucose
- [2-Deoxy-D-arabino-hexose; antimetabolite of glucose with antiviral activity. ( CSP )] (UMLS (CSP) C0011501) =Carbohydrate; Pharmacologic Substance ;
=DEXTROSE;
|
- 7. 1-Deoxy-1-(methylamino)-D-glucitol 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoate
- [The meglumine salt form of ioxaglate, an organic iodine compound and a radiographic contrast medium. Ioxaglate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by ioxaglate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of ioxaglate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0205807) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOXAGLATE;
=IOXAGLATE MEGLUMINE 393 MG/ML;
| - 32. deoxyguanosine
- [nucleoside component of DNA; composed of guanine and deoxyribose. ( CSP )] (UMLS (CSP) C0011503) =Nucleic Acid, Nucleoside, or Nucleotide =deoxyribonucleoside;
guanine nucleoside |
- 8. 1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate
- [The meglumine salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. Iothalamate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iothalamate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iothalamate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0022033) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOTHALAMATE;
MEGLUMINE;
Triiodobenzoic Acids;
=Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Monosodium Salt;
IOTHALAMATE MEGLUMINE 60 %;
IOTHALAMATE MEGLUMINE 43 %;
IOTHALAMATE MEGLUMINE 17.2 %;
IOTHALAMATE MEGLUMINE 30 %;
IOTHALAMATE MEGLUMINE 52 %;
| - 33. Deoxyhypusine Synthase
- [Deoxyhypusine Synthase is encoded by the DHPS gene. The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity. (from LocusLink) ( NCI )] (UMLS (NCI) C0082226) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 9. 15-Deoxyspergualin Hydrochloride
- (UMLS (NCI) C0284558) =Organic Chemical; Pharmacologic Substance ;
| - 34. Deoxyhypusine Synthase Gene
- [This gene plays a role in cell proliferation and protein synthesis. ( NCI )] (UMLS (NCI) C1367701) DHPS;
DHPS Gene;
=Gene or Genome |
- 10. 2'-Deoxy-5-azacytidine
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0049065) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 35. Deoxynucleotidyl Terminal Transferase
- [Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells. ( NCI )] (UMLS (NCI) C0012881) =Amino Acid, Peptide, or Protein; Enzyme
|
- 11. 2'-Deoxy-5-trifluoromethyluridine
- [A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04) ( NCI )] (UMLS (NCI) C0040987) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=dT;
[OP203] ANTIVIRALS, TOPICAL OPHTHALMIC =TRIFLURIDINE 1 % | - 36. Deoxynucleotidyltransferase, Terminal Gene
- [This gene is involved in DNA synthesis. It also plays a role in the generation of antigen diversity in pre-B and pre-T lymphocytes during early differentiation. ( NCI )] (UMLS (NCI) C1333243) DNTT;
DNTT Gene;
=Gene or Genome ;
|
- 12. 2'-Deoxycytidine Kinase
- [Deoxycytidine Kinase, encoded by the DCK gene, is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. (from LocusLink) ( NCI )] (UMLS (NCI) C0011486) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 37. deoxyribonuclease
- [Enzymes that catalyze the hydrolytic cleavage of phosphodiester bond linkages in the DNA backbone. Deoxyribonucleases belong to a larger family of nucleases, which cleave DNA bases at various positions in the DNA backbone. ( NCI )] (UMLS (CSP) C0011522) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme =Ester Hydrolase;
Inactive Ingredient Preparations =endodeoxyribonuclease;
DESOXYRIBONUCLEASE 15000 UNT |
- 13. 2'-Deoxythymidine
- [A pyrimidine nucleoside component of DNA comprised of thymidine linked by its N1 nitrogen to the C1 carbon of deoxyribose. ( NCI )] (UMLS (NCI) C0086126) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
| - 38. deoxyribonuclease I
- [An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA. ( MSH )] (UMLS (CSP) C0011519) =Amino Acid, Peptide, or Protein; Enzyme ;
=endodeoxyribonuclease;
=dornase alfa;
|
- 14. 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
- [2-deoxy-2-(3-methyl-3-nitrosoureido) -D-glucopyranose; USP antineoplastic antibiotic; at high doses it destroys pancreatic beta cells and can be used to create experimental animal models of diabetes mellitus. ( CSP )] (UMLS (NCI) C0038432) =Carbohydrate; Antibiotic ;
=[AM300] AMINOGLYCOSIDES;
antineoplastic antibiotics;
nitrosourea;
=STREPTOZOCIN 1 GM/VIL;
| - 39. deoxyribonuclease IV
- [ ] (UMLS (CSP) C0598371) =Amino Acid, Peptide, or Protein; Enzyme
|
- 15. 2-Deoxyphenobarbital
- [An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties. ( NCI )] (UMLS (NCI) C0033148) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione =PRIMIDONE 250 MG;
PRIMIDONE 50 MG;
PRIMIDONE 250 MG/5ML | - 40. deoxyribonucleic acid
- [deoxyribonucleotide polymer that is the primary genetic material of all cells; eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions; DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). ( CSP )] (UMLS (CSP) C0012854) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =Nucleic Acid;
=cDNA;
bacterial DNA;
circular DNA;
Construct;
rDNA;
virus DNA;
Z DNA;
extrachromosomal DNA;
|
- 16. 3' deoxyadenosine
- [An anticancer drug that belongs to a family of drugs called antitumor antibiotics. ( NCI )] (UMLS (CSP) C0056331) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 41. deoxyribonucleoprotein
- [Proteins conjugated with deoxyribonucleic acids (DNA) or specific DNA. ( MSH )] (UMLS (CSP) C0011527) =Nucleic Acid, Nucleoside, or Nucleotide; Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 17. 3'-Deoxyadenosine-5'-(tetrahydrogen triphosphate)
- [The triphosphate salt of Cordycepin, a purine nucleoside antimetabolite analogue and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Cordycepin incorporates into RNA, and, inhibits RNA chain elongation and synthesis due to the absence of a hydroxyl moiety at the 3' position. Because it is converted to an inactive metabolite by adenosine deaminase, this agent must be administered with an adenosine deaminase inhibitor in order to be effective. Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro. (NCI04) ( NCI )] (UMLS (NCI) C0046803) =Nucleic Acid, Nucleoside, or Nucleotide; Antibiotic
| - 42. deoxyribonucleoside
- [nucleoside having a purine or pyrimidine base bonded to deoxyribose. ( CSP )] (UMLS (CSP) C0011528) =Nucleic Acid, Nucleoside, or Nucleotide =nucleoside;
=deoxycytidine;
deoxyguanosine;
deoxyuridine;
dT;
deoxyadenosine;
2'3' dideoxynucleoside;
Abacavir;
Deoxyadenosines;
deoxycytidine;
deoxyuridine;
Dideoxynucleosides;
(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;
dT;
|
- 18. 4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine
- [A novel fluorinated Vinca alkaloid with antiangiogenic and antitumor activities. Although the exact mechanism of the mitotic block is not clear, vinflunine could induce cell cycle arrest at G2/M phase, and cause a concentration-dependent reduction of the microtubular network of interphase cells, thereby leading to apoptosis. This agent appears to function as an inhibitor of tubulin assembly, while exhibiting quantitatively different behaviors and showing lower binding capacity than the classic Vinca alkaloids. Furthermore, vinflunine exhibits improved pharmacokinetic properties, including increased lipophilicity, and is more resistant to metabolic degradation. ( NCI )] (UMLS (NCI) C0672663) =Organic Chemical; Pharmacologic Substance ;
| - 43. deoxyribonucleoside triphosphate
- [glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. ( CSP )] (UMLS (CSP) C0596418) =Nucleic Acid, Nucleoside, or Nucleotide =nucleoside triphosphate;
|
- 19. 4'-Deoxy-4'-Iododoxorubicin
- [A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues. ( NCI )] (UMLS (NCI) C0047758) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 44. deoxyribonucleotide
- [purine or pyrimidine base bonded to a deoxyribose containing a bond to a phosphate group. ( CSP )] (UMLS (CSP) C0011529) =Nucleic Acid, Nucleoside, or Nucleotide =nucleotide;
|
- 20. 4'-Deoxyadriamycin
- [A synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin. Esorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause severe myelosuppression. (NCI04) ( NCI )] (UMLS (NCI) C0047760) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 45. deoxyribopolynucleotide
- [ ] (UMLS (CSP) C0596419) =Nucleic Acid, Nucleoside, or Nucleotide =polynucleotide;
|
- 21. 4'-Deoxyadriamycin Hydrochloride
- (UMLS (NCI) C0955070) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 46. deoxyribose
- [deoxypentose found in deoxyribonucleic acids, deoxyribonucleotides, and deoxyribnuceosides. ( CSP )] (UMLS (CSP) C0011530) =Carbohydrate; Biologically Active Substance ;
=ribose;
|
- 22. 4'-Deoxyepivincristine
- [A vinca alkaloid compound and semi-synthetic vincristine derivative with antineoplastic activity. Vinepidine binds to and stabilizes tubulin, thereby preventing tubulin polymerization and depolymerization, which result in microtubule assembly and disassembly, respectively. Treated cells are unable to complete mitosis process and are arrested in the metaphase, thereby leading to an inhibition of cell growth. ( NCI )] (UMLS (NCI) C0078255) =Organic Chemical; Pharmacologic Substance ;
| - 47. Deoxyspergualin/Monoclonal Antibody L6
- (UMLS (NCI) C0281026) =Therapeutic or Preventive Procedure
|
- 23. 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0671970) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
deoxycytidine =CAPECITABINE 150 MG;
CAPECITABINE 500 MG | - 48. deoxysugar
- [ ] (UMLS (CSP) C0011471) =Carbohydrate
|
- 24. 5'-Deoxy-5-fluorouridine
- [A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand. ( NCI )] (UMLS (NCI) C0048808) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 49. deoxyuridine
- [2'-deoxyuridine; an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. ( CSP )] (UMLS (CSP) C0011535) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
=deoxyribonucleoside;
UR;
uracil nucleoside;
=5 bromodeoxyuridine;
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;
1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil;
5 fluorouridine;
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;
1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil |
- 25. 6-deoxy-3,5 di-O-methyl 6-(3-methyl-3-nitrosoureido)-alpha-D-glucofuranoside
- (UMLS (NCI) C0116847) =Organic Chemical; Pharmacologic Substance ;
| |
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