[Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells. ( NCI )]
UMLS (NCI) C0012881 - Amino Acid, Peptide, or Protein
- Enzyme
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