[intracellular knots or clumps of neurofibrils seen in various parts of the brain in Alzheimer's disease; composed of dense arrays of paired helical filaments (neurofilaments and microtubules) and incorporating the following proteins: intermediate filaments, medium and high molecular weight neurofilaments, microtubule associated proteins, map2 and tau, actin, and ubiquitins. ( CSP )]
UMLS (CSP) C0085400 Relation/PAR: Nerve Degeneration
Relation/CHD: paired helical filament