- 1. (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
- [An anticancer drug that belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0285590) =Organic Chemical; Pharmacologic Substance ;
=Anilides;
[AN000] ANTINEOPLASTICS =BICALUTAMIDE 50 MG | - 13. NCK Adaptor Protein 2 Gene
- [This gene plays a role in signal transduction and is involved in cytoskeletal reorganization. ( NCI )] (UMLS (NCI) C1334864) NCK2;
NCK2 Gene;
=Gene or Genome ;
|
- 2. 6-NC
- [A synthetic solid appearing as chrome-red crystals or orange-yellow to light-yellow needles that is slightly soluble in acetic acid, cold ethanol, diethyl ether, benzene, and carbon disulfide, and soluble in hot nitrobenzene. It is not used for any commercial applications and is used only for research purposes, principally as an internal standard in the chemical analysis of nitroarenes. The primary route of potential human exposure to 6-nitrochrysene is inhalation. Low concentrations of this chemical have been found in ambient airborne particulates. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0049682) =Organic Chemical; Hazardous or Poisonous Substance
| - 14. NCOA1
- [This gene plays a role in regulation of transcription. ( NCI )] (UMLS (NCI) C1334866) NCOA1 Gene;
Nuclear Receptor Coactivator 1 Gene;
=Gene or Genome ;
|
- 3. 9-NC
- [An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors. ( NCI )] (UMLS (NCI) C0213800) =Organic Chemical; Pharmacologic Substance ;
| - 15. NCOA2
- [This gene is involved in regulation of transcription. It also plays a role in myogenic differentiation. ( NCI )] (UMLS (NCI) C1334867) NCOA2 Gene;
Nuclear Receptor Coactivator 2 Gene;
=Gene or Genome ;
|
- 4. N carbamoylaminoacid
- [ ] (UMLS (CSP) C0597004) =Amino Acid, Peptide, or Protein
| - 16. NCOA3
- [This gene plays a role in regulation of transcription. ( NCI )] (UMLS (NCI) C1334868) NCOA3 Gene;
Nuclear Receptor Coactivator 3 Gene;
=Gene or Genome ;
|
- 5. N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine
- [A synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0031441) =Organic Chemical; Pharmacologic Substance ;
=Ethylamines;
sympatholytic agent =PHENOXYBENZAMINE HYDROCHLORIDE | - 17. NCOA4
- [This gene is involved in the transcriptional activation of target genes. ( NCI )] (UMLS (NCI) C0812260) NCOA4 Gene;
Nuclear Receptor Coactivator 4 Gene =Gene or Genome |
- 6. N-[1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl]-2-oxo-1,2-dihydropyrimidin-4-yl}hexadecanamide
- [An orally bioavailable pyrimidine analog with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analog CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into its active triphosphate form. As an analog of deoxycytidine triphosphate, CNDAC triphosphate molecules get incorporated into DNA strands during replication, thereby leading to single-stranded DNA breaks caused by beta-elimination in fidelity check point. As a result, this agent induces cell cycle arrest in the G2 phase and subsequently triggers apoptosis. ( NCI )] (UMLS (NCI) C0764827) Sapacitabine;
=Organic Chemical | - 18. NCOA5
- [This gene is involved in regulation of transcription. ( NCI )] (UMLS (NCI) C1334869) NCOA5 Gene;
Nuclear Receptor Coactivator 5 Gene;
=Gene or Genome ;
|
- 7. NC
- [A country in the Pacific, comprised of islands in the South Pacific Ocean, east of Australia. (NCI) ( NCI )] (UMLS (NCI) C0027964) =Geographic Area
| - 19. NCOA6
- [This gene plays a role in the transcriptional activation of target genes. ( NCI )] (UMLS (NCI) C1367177) NCOA6 Gene;
Nuclear Receptor Coactivator 6 Gene =Gene or Genome |
- 8. NC
- [A state in the mid-atlantic United States. Its capital is Raleigh. ( NCI )] (UMLS (NCI) C0028407) =Geographic Area
| - 20. NCOR1
- [This gene is involved in chromatin remodeling and repression of transcription. ( NCI )] (UMLS (NCI) C1334870) NCOR1 Gene;
Nuclear Receptor Co-Repressor 1 Gene;
=Gene or Genome ;
|
- 9. NC-45
- (UMLS (NCI) C0733720) =Steroid; Pharmacologic Substance ;
| - 21. NCOR2
- [SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (from OMIM 600848 and NCI) ( NCI )] (UMLS (NCI) C0382270) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 10. NCAM1
- [This gene plays a role in cellular adhesion mechanisms that involve cell-cell and cell-matrix interactions. ( NCI )] (UMLS (NCI) C1334863) NCAM1 Gene;
Neural Cell Adhesion Molecule 1 Gene;
=Gene or Genome ;
| - 22. NCOR2
- [This gene plays a role in repression of transcription. It is also involved in chromatin remodeling. ( NCI )] (UMLS (NCI) C1334871) NCOR2 Gene;
Nuclear Receptor Co-Repressor 2 Gene;
=Gene or Genome ;
|
- 11. NCI Thesaurus
- [The NCI Thesaurus is a product of NCI's Enterprise Vocabulary Services. It arose from the need to have an institute wide common terminology to integrate the diverse data systems in use throughout NCI. Centralized coding of research related activities helped to meet various responsibilities of the Institute; however, supplementary data coding assigned independently by various components of the NCI made it difficult to find and combine related information across programs. By incorporating the terms in use by the various programs and mapping those to unique concepts, it was intended that the NCI Thesaurus would facilitate interoperability and data sharing within NCI. The NCI Thesaurus is a rigorous, cancer-centric, formal reference vocabulary with true is_a taxonomic structure, polyhierarchy, inferred partonomy, and other features that make it suitable for supporting complex query operations against appropriately coded data repositories. ( NCI )] (UMLS (NCI) C1140168) Thesaurus =Intellectual Product =gene;
living system;
Chromosomal, Gene, or Protein Abnormality;
Biological Function;
Abnormal Cell;
cancer chemotherapy;
Activity;
Conceptual Entity;
Diagnostic or Prognostic Factor;
Disease, Disorder or Finding;
NCI Administrative Concept;
Property or Attribute;
Anatomic Structure, System, or Substance;
Experimental Organism Anatomical Concept;
Experimental Organism Diagnosis;
Diagnostic, Therapeutic, and Research Equipment;
Gene Product;
Biochemical Pathway;
Drug, Food, Chemical or Biomedical Material;
| - 23. NCS
- [antitumor protein possessing a regulatory function on the metabolism of DNA; also a potent cytostatic agent active against gram-positive bacteria. ( CSP )] (UMLS (NCI) C0027597) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance =antineoplastic antibiotics;
Peptides |
- 12. NCI Tumor Grade in Sarcoma
- (UMLS (NCI) C1335921) Sarcoma by NCI Grade =Neoplastic Process
| - 24. NCX 4016
- (UMLS (NCI) C0950966) =Organic Chemical; Pharmacologic Substance
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