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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
O O- O0 O1 O2 O3 OA OB OC OD OE OF OG OH OI OJ OK OL OM ON OO OP OR OS OT OU OV OW OX OY OZ
ODC ODD ODE ODF ODI ODO

ODF

[Most highly expressed in lymph nodes and upregulated by TCR stimulation, human TNFSF11 Gene (TNF Family) encodes alternative isoforms of 35-kDa (precursor) homotrimeric cytokine Tumor Necrosis Factor Ligand Superfamily Member 11, which binds as an osteoclast activation and differentiation ligand to TNFRSF11B/OPG and to TNFRSF11A/RANK. Isoforms 1 and 3 are type II membrane proteins; isoform 2 is secreted. A soluble form of isoform 1 likely derives from proteolytic processing by ADAM17. TNFSF11 activates antiapoptotic kinase AKT/PKB through a SRC kinase/TRAF6 signaling complex and augments or regulates dendritic cell stimulation of naive T-cell proliferation. (NCI) ( NCI )]
UMLS (NCI) C0666364
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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