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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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ME ME ME2 MEA MEB MEC MED MEE MEF MEG MEI MEL MEM MEN MEP MEQ MER MES MET MEV MEX MEZ

Merlin

[Merlin protein (schwannomin, NF2 gene product) exhibits similarity to erythrocyte protein 4.1 and members of the ERM family (moesin, ezrin, and radixin), proteins thought to link cytoskeletal components with cell membrane proteins. Mutant merlin proteins alter cell adhesion, causing cells to detach from the substratum, a possible step in the pathogenesis of NF2. Merlin binds to the ERM-interacting phosphoprotein EBP-50. Merlin may maintain normal cytoskeletal organization. Schwannomin interacts with the HGF-regulated tyrosine kinase substrate HRS. Schwannomin and HRS co-localize at endosomes suggesting that schwannomin is involved in HRS-mediated cell signaling. (from OMIM 101000 and NCI) ( NCI )]
UMLS (NCI) C0254123
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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