Frizzled-Related Protein

[Encoded by human SFRP4 Gene (SFRP Family), Secreted Frizzled-Related Protein 4 is a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI) ( NCI )]

UMLS (NCI) C0913338

FRPHE
Secreted Frizzled-Related Protein 4
SFRP4