Axil

[Encoded by human AXIN2 Gene, ubiquitous cytoplasmic Conductin may inhibit the WNT pathway by regulating beta-catenin stability. AXIN2 contains DIX, RGS-signaling, GSK-binding, beta-catenin-binding, and DSH domains. Mouse conductin organizes an APC/beta-catenin/GSK3B complex that promotes beta-catenin degradation. Conductin may facilitate phosphorylation of APC and beta-catenin by GSK3B. Armadillo repeats mediate interaction with beta-catenin. GSK3B may phosphorylate AXIN2, likely dephosphorylated by PP2A. Colorectal cancer associated with MMR gene alterations result in AXIN2 mutations, stabilization of beta-catenin, and activation of beta-catenin/TCF signaling. (from SWISS-PROT, OMIM, Proteome, and NCI) ( NCI )]

UMLS (NCI) C1332360

Axin 2
AXIN2
Axis Inhibitor 2
Conductin