Adaptor Protein Containing PH and SH2 Domains

[Encoded by human APS Gene, 85 kD APS Protein appears to be found in spleen, prostate, testis, uterus, small intestine, skeletal muscle, and peripheral blood leukocytes. The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site. APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking. APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation. (OMIM and NCI) ( NCI )]

UMLS (NCI) C1449108

Adaptor Protein with Pleckstrin Homology and SRC Homology 2 Domains
APS
APS Protein